Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis
•Melatonin had beneficial effects on outcomes in assisted reproductive technologies, but it had no influence on pregnancy.•Melatonin had beneficial effects such as the improvement in the fertilization rate.•Melatonin has a beneficial effect on the formation of mature oocytes (MII). Melatonin is a ho...
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| Veröffentlicht in: | Clinics (São Paulo, Brazil) Brazil), 2024-01, Vol.79, p.100397, Article 100397 |
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| container_title | Clinics (São Paulo, Brazil) |
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| creator | Veiga, Eduardo Carvalho de Arruda Samama, Marise Ikeda, Fabio Cavalcanti, Giovanna Santos Sartor, Amanda Parames, Suelen Fernanda Baracat, Edmund C. Ueno, Joji Junior, Jose Maria Soares |
| description | •Melatonin had beneficial effects on outcomes in assisted reproductive technologies, but it had no influence on pregnancy.•Melatonin had beneficial effects such as the improvement in the fertilization rate.•Melatonin has a beneficial effect on the formation of mature oocytes (MII).
Melatonin is a hormone produced by the pineal gland and it has antioxidant properties.
This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.
Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.
The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).
Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate. |
| doi_str_mv | 10.1016/j.clinsp.2024.100397 |
| format | Article |
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Melatonin is a hormone produced by the pineal gland and it has antioxidant properties.
This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.
Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.
The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).
Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.</description><identifier>ISSN: 1807-5932</identifier><identifier>ISSN: 1980-5322</identifier><identifier>EISSN: 1980-5322</identifier><identifier>DOI: 10.1016/j.clinsp.2024.100397</identifier><identifier>PMID: 38971124</identifier><language>eng</language><publisher>United States: Elsevier España, S.L.U</publisher><subject>Antioxidants - pharmacology ; Assisted reproduction outcomes ; Female ; Fertilization - drug effects ; Fertilization - physiology ; Fertilization in Vitro - drug effects ; Fertilization in Vitro - methods ; Human reproduction ; Humans ; In vitro fertilization ; MEDICINE, GENERAL & INTERNAL ; Melatonin ; Melatonin - pharmacology ; Melatonin - therapeutic use ; Ovarian hyperstimulation syndrome ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Reproductive Techniques, Assisted ; Review ; Sytematic review</subject><ispartof>Clinics (São Paulo, Brazil), 2024-01, Vol.79, p.100397, Article 100397</ispartof><rights>2024 HCFMUSP</rights><rights>Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.</rights><rights>2024 HCFMUSP. Published by Elsevier España, S.L.U. 2024 HCFMUSP</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c336t-2ea0b8c1db6dad78fa63b0970b5e7d7ba88c5250431e6b426a2a1bca2a3255473</cites><orcidid>0000-0002-3732-1057 ; 0000-0002-0167-861X ; 0000-0002-6710-8716 ; 0000-0003-0774-9404</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265587/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265587/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38971124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veiga, Eduardo Carvalho de Arruda</creatorcontrib><creatorcontrib>Samama, Marise</creatorcontrib><creatorcontrib>Ikeda, Fabio</creatorcontrib><creatorcontrib>Cavalcanti, Giovanna Santos</creatorcontrib><creatorcontrib>Sartor, Amanda</creatorcontrib><creatorcontrib>Parames, Suelen Fernanda</creatorcontrib><creatorcontrib>Baracat, Edmund C.</creatorcontrib><creatorcontrib>Ueno, Joji</creatorcontrib><creatorcontrib>Junior, Jose Maria Soares</creatorcontrib><title>Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis</title><title>Clinics (São Paulo, Brazil)</title><addtitle>Clinics (Sao Paulo)</addtitle><description>•Melatonin had beneficial effects on outcomes in assisted reproductive technologies, but it had no influence on pregnancy.•Melatonin had beneficial effects such as the improvement in the fertilization rate.•Melatonin has a beneficial effect on the formation of mature oocytes (MII).
Melatonin is a hormone produced by the pineal gland and it has antioxidant properties.
This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.
Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.
The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).
Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.</description><subject>Antioxidants - pharmacology</subject><subject>Assisted reproduction outcomes</subject><subject>Female</subject><subject>Fertilization - drug effects</subject><subject>Fertilization - physiology</subject><subject>Fertilization in Vitro - drug effects</subject><subject>Fertilization in Vitro - methods</subject><subject>Human reproduction</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Melatonin</subject><subject>Melatonin - pharmacology</subject><subject>Melatonin - therapeutic use</subject><subject>Ovarian hyperstimulation syndrome</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Rate</subject><subject>Reproductive Techniques, Assisted</subject><subject>Review</subject><subject>Sytematic review</subject><issn>1807-5932</issn><issn>1980-5322</issn><issn>1980-5322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRCIfsA_QChHLln8EccJBxCqWkBq1UPhbE3sWfAqsRfbWbT8-jpKqeDCxbbmvTczfo-QV4xuGGXt293GjM6n_YZT3pQSFb16Qk5Z39FaCs6flndHVS17wU_IWUq7hSIa-ZyciK5XjPHmlJgbHCEH73zlpn0MB0zVFmN2o_sN2QVfRchYFRhScimjrSIWnp3Ngr6r7o6lOBWqKcDB4a8KvK0mzFCDh_FYRC_Isy2MCV8-3Ofk29Xl14vP9fXtpy8XH69rI0Sba45Ah84wO7QWrOq20IqB9ooOEpVVA3SdkVzSRjBsh4a3wIENppyCS9kocU42a99kHI5B78IcywpJ3y1G6MWIxStKaXGroX0RfFgF-3mY0Br0OcKo99FNEI86gNP_It790N_DQRfvWim7ZeSbhw4x_JwxZT25ZHAcwWOYkxZUtQ0XUrFCbVaqiSGliNvHOYzqJVG902uietlSr4kW2eu_d3wU_YmwEN6vBCzWlgCiXr7vDVoX0WRtg_v_hHuS-rS4</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Veiga, Eduardo Carvalho de Arruda</creator><creator>Samama, Marise</creator><creator>Ikeda, Fabio</creator><creator>Cavalcanti, Giovanna Santos</creator><creator>Sartor, Amanda</creator><creator>Parames, Suelen Fernanda</creator><creator>Baracat, Edmund C.</creator><creator>Ueno, Joji</creator><creator>Junior, Jose Maria Soares</creator><general>Elsevier España, S.L.U</general><general>Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo</general><general>Faculdade de Medicina / USP</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><orcidid>https://orcid.org/0000-0002-3732-1057</orcidid><orcidid>https://orcid.org/0000-0002-0167-861X</orcidid><orcidid>https://orcid.org/0000-0002-6710-8716</orcidid><orcidid>https://orcid.org/0000-0003-0774-9404</orcidid></search><sort><creationdate>20240101</creationdate><title>Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis</title><author>Veiga, Eduardo Carvalho de Arruda ; Samama, Marise ; Ikeda, Fabio ; Cavalcanti, Giovanna Santos ; Sartor, Amanda ; Parames, Suelen Fernanda ; Baracat, Edmund C. ; Ueno, Joji ; Junior, Jose Maria Soares</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-2ea0b8c1db6dad78fa63b0970b5e7d7ba88c5250431e6b426a2a1bca2a3255473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antioxidants - pharmacology</topic><topic>Assisted reproduction outcomes</topic><topic>Female</topic><topic>Fertilization - drug effects</topic><topic>Fertilization - physiology</topic><topic>Fertilization in Vitro - drug effects</topic><topic>Fertilization in Vitro - methods</topic><topic>Human reproduction</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Melatonin</topic><topic>Melatonin - pharmacology</topic><topic>Melatonin - therapeutic use</topic><topic>Ovarian hyperstimulation syndrome</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Rate</topic><topic>Reproductive Techniques, Assisted</topic><topic>Review</topic><topic>Sytematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Veiga, Eduardo Carvalho de Arruda</creatorcontrib><creatorcontrib>Samama, Marise</creatorcontrib><creatorcontrib>Ikeda, Fabio</creatorcontrib><creatorcontrib>Cavalcanti, Giovanna Santos</creatorcontrib><creatorcontrib>Sartor, Amanda</creatorcontrib><creatorcontrib>Parames, Suelen Fernanda</creatorcontrib><creatorcontrib>Baracat, Edmund C.</creatorcontrib><creatorcontrib>Ueno, Joji</creatorcontrib><creatorcontrib>Junior, Jose Maria Soares</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><jtitle>Clinics (São Paulo, Brazil)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veiga, Eduardo Carvalho de Arruda</au><au>Samama, Marise</au><au>Ikeda, Fabio</au><au>Cavalcanti, Giovanna Santos</au><au>Sartor, Amanda</au><au>Parames, Suelen Fernanda</au><au>Baracat, Edmund C.</au><au>Ueno, Joji</au><au>Junior, Jose Maria Soares</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis</atitle><jtitle>Clinics (São Paulo, Brazil)</jtitle><addtitle>Clinics (Sao Paulo)</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>79</volume><spage>100397</spage><pages>100397-</pages><artnum>100397</artnum><issn>1807-5932</issn><issn>1980-5322</issn><eissn>1980-5322</eissn><abstract>•Melatonin had beneficial effects on outcomes in assisted reproductive technologies, but it had no influence on pregnancy.•Melatonin had beneficial effects such as the improvement in the fertilization rate.•Melatonin has a beneficial effect on the formation of mature oocytes (MII).
Melatonin is a hormone produced by the pineal gland and it has antioxidant properties.
This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.
Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.
The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).
Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.</abstract><cop>United States</cop><pub>Elsevier España, S.L.U</pub><pmid>38971124</pmid><doi>10.1016/j.clinsp.2024.100397</doi><orcidid>https://orcid.org/0000-0002-3732-1057</orcidid><orcidid>https://orcid.org/0000-0002-0167-861X</orcidid><orcidid>https://orcid.org/0000-0002-6710-8716</orcidid><orcidid>https://orcid.org/0000-0003-0774-9404</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1807-5932 |
| ispartof | Clinics (São Paulo, Brazil), 2024-01, Vol.79, p.100397, Article 100397 |
| issn | 1807-5932 1980-5322 1980-5322 |
| language | eng |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Antioxidants - pharmacology Assisted reproduction outcomes Female Fertilization - drug effects Fertilization - physiology Fertilization in Vitro - drug effects Fertilization in Vitro - methods Human reproduction Humans In vitro fertilization MEDICINE, GENERAL & INTERNAL Melatonin Melatonin - pharmacology Melatonin - therapeutic use Ovarian hyperstimulation syndrome Pregnancy Pregnancy Outcome Pregnancy Rate Reproductive Techniques, Assisted Review Sytematic review |
| title | Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis |
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