Down-regulation of long noncoding RNA HOXA11-AS nullifies the impact of microRNA-506–3p on chondrocytes proliferation and apoptosis in osteoarthritis

•HOXA11-AS silencing restrained HCOA cell proliferation and accelerated their apoptosis.•HOXA11-AS overexpression increased PIK3CA expression through binding to miR-506–3p.•HOXA11-AS overexpression represses PI3K/AKT/mTOR pathway through miR-506–3p down-regulation. This study was directed towards ex...

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Veröffentlicht in:	Clinics (São Paulo, Brazil) Brazil), 2024-01, Vol.79, p.100393, Article 100393
Hauptverfasser:	Zhang, Ziyang, Guo, Renhao, Cai, Chengfa, Guo, Pengcheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Cartilage, Articular - metabolism Cell Proliferation - genetics Cells, Cultured Chondrocytes Chondrocytes - metabolism Down-Regulation Female Humans Long noncoding rna hoxa11-as Male MEDICINE, GENERAL & INTERNAL Microrna-506–3p MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Original Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - pathology PI3K/AKT/mTOR pathway Proliferation Proto-Oncogene Proteins c-akt - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism TOR Serine-Threonine Kinases - metabolism
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