Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years
• Evaluation of disagreement between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.• 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings, mainly caused by infections.• Pneumonia, pulmona...
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creator | Ribeiro, Maira P. Duarte-Neto, Amaro N. Dolhnikoff, Marisa Lindoso, Livia Lourenço, Benito Marques, Heloisa H. Pereira, Maria F.B. Cristofani, Lilian M. Odone-Filho, Vicente Campos, Lucia M.A. Sallum, Adriana M.E. Carneiro-Sampaio, Magda Delgado, Artur F. Carvalho, Werther B. Mauad, Thais Silva, Clovis A. |
description | • Evaluation of disagreement between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.• 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings, mainly caused by infections.• Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were identified at autopsy findings in the groups with major discrepancies.
To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.
A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59).
Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018).
This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies. |
doi_str_mv | 10.1016/j.clinsp.2023.100184 |
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To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.
A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59).
Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018).
This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.</description><identifier>ISSN: 1807-5932</identifier><identifier>ISSN: 1980-5322</identifier><identifier>EISSN: 1980-5322</identifier><identifier>DOI: 10.1016/j.clinsp.2023.100184</identifier><identifier>PMID: 36972631</identifier><language>eng</language><publisher>United States: Elsevier España, S.L.U</publisher><subject>Adolescent ; Autopsy ; Cause of Death ; Child ; Chronic Disease ; Chronic diseases ; Cross-Sectional Studies ; Death ; Diagnostic Errors ; Humans ; Lung Abscess ; Male ; MEDICINE, GENERAL & INTERNAL ; Original ; Pneumonia ; Retrospective Studies ; Saccharomyces cerevisiae ; Yeast</subject><ispartof>Clinics (São Paulo, Brazil), 2023-01, Vol.78, p.100184-100184, Article 100184</ispartof><rights>2023 HCFMUSP</rights><rights>Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.</rights><rights>2023 HCFMUSP. Published by Elsevier España, S.L.U. 2023 HCFMUSP</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-378ea7f5dda59b679be48d6b6df463146bd4097f424731c86fa86b2bc7b8b4623</citedby><cites>FETCH-LOGICAL-c503t-378ea7f5dda59b679be48d6b6df463146bd4097f424731c86fa86b2bc7b8b4623</cites><orcidid>0000-0003-3452-8789 ; 0000-0002-4535-0894 ; 0000-0002-1924-4043</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091384/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091384/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36972631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro, Maira P.</creatorcontrib><creatorcontrib>Duarte-Neto, Amaro N.</creatorcontrib><creatorcontrib>Dolhnikoff, Marisa</creatorcontrib><creatorcontrib>Lindoso, Livia</creatorcontrib><creatorcontrib>Lourenço, Benito</creatorcontrib><creatorcontrib>Marques, Heloisa H.</creatorcontrib><creatorcontrib>Pereira, Maria F.B.</creatorcontrib><creatorcontrib>Cristofani, Lilian M.</creatorcontrib><creatorcontrib>Odone-Filho, Vicente</creatorcontrib><creatorcontrib>Campos, Lucia M.A.</creatorcontrib><creatorcontrib>Sallum, Adriana M.E.</creatorcontrib><creatorcontrib>Carneiro-Sampaio, Magda</creatorcontrib><creatorcontrib>Delgado, Artur F.</creatorcontrib><creatorcontrib>Carvalho, Werther B.</creatorcontrib><creatorcontrib>Mauad, Thais</creatorcontrib><creatorcontrib>Silva, Clovis A.</creatorcontrib><title>Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years</title><title>Clinics (São Paulo, Brazil)</title><addtitle>Clinics (Sao Paulo)</addtitle><description>• Evaluation of disagreement between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.• 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings, mainly caused by infections.• Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were identified at autopsy findings in the groups with major discrepancies.
To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.
A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59).
Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018).
This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.</description><subject>Adolescent</subject><subject>Autopsy</subject><subject>Cause of Death</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Chronic diseases</subject><subject>Cross-Sectional Studies</subject><subject>Death</subject><subject>Diagnostic Errors</subject><subject>Humans</subject><subject>Lung Abscess</subject><subject>Male</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Original</subject><subject>Pneumonia</subject><subject>Retrospective Studies</subject><subject>Saccharomyces cerevisiae</subject><subject>Yeast</subject><issn>1807-5932</issn><issn>1980-5322</issn><issn>1980-5322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuO1DAQjBCIfcAfIOQjlwx-JbEvILSCBWkRB-BsOXZnxlHGDnayq_kGfhqbLCu4cPCzq6q7q6vqBcE7gkn7etyZyfk07yimLH9hIvij6pxIgeuGUfo43wXu6kYyelZdpDRizCTjzdPqjLWyoy0j59XPz3oMEVmXTIRZe3NCPSx3AB4VeWf0lIN670NyCYUBWdDLAWlv89JLOIY5v8MU9r-hg_PW-X1CziNtwwTJgF8SunOZZA4xZMWSDHSChOwaMxgRUZ9Ax_SsejLoKcHz-_Oy-v7h_berj_XNl-tPV-9uatNgttSsE6C7obFWN7JvO9kDF7btWzvw3BNve8ux7AZOeceIEe2gRdvT3nS96HlL2WW123STcTAFNYY1-pxQfS2GqWJY8RRnSzGmVGbC240wr_0RbGkp6knN0R11PKmgnfo34t1B7cOtynxJmOBZ4dW9Qgw_VkiLOmbHYZq0h7AmRTtJucxbqY5vUBNDShGGhzwEqzJ5Napt8qpUqbbJZ9rLv2t8IP0ZdQa82QCQrb11EFVp3xuwLoJZlA3u_xl-AeDawtA</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Ribeiro, Maira P.</creator><creator>Duarte-Neto, Amaro N.</creator><creator>Dolhnikoff, Marisa</creator><creator>Lindoso, Livia</creator><creator>Lourenço, Benito</creator><creator>Marques, Heloisa H.</creator><creator>Pereira, Maria F.B.</creator><creator>Cristofani, Lilian M.</creator><creator>Odone-Filho, Vicente</creator><creator>Campos, Lucia M.A.</creator><creator>Sallum, Adriana M.E.</creator><creator>Carneiro-Sampaio, Magda</creator><creator>Delgado, Artur F.</creator><creator>Carvalho, Werther B.</creator><creator>Mauad, Thais</creator><creator>Silva, Clovis A.</creator><general>Elsevier España, S.L.U</general><general>Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo</general><general>Faculdade de Medicina / USP</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><orcidid>https://orcid.org/0000-0003-3452-8789</orcidid><orcidid>https://orcid.org/0000-0002-4535-0894</orcidid><orcidid>https://orcid.org/0000-0002-1924-4043</orcidid></search><sort><creationdate>20230101</creationdate><title>Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years</title><author>Ribeiro, Maira P. ; Duarte-Neto, Amaro N. ; Dolhnikoff, Marisa ; Lindoso, Livia ; Lourenço, Benito ; Marques, Heloisa H. ; Pereira, Maria F.B. ; Cristofani, Lilian M. ; Odone-Filho, Vicente ; Campos, Lucia M.A. ; Sallum, Adriana M.E. ; Carneiro-Sampaio, Magda ; Delgado, Artur F. ; Carvalho, Werther B. ; Mauad, Thais ; Silva, Clovis A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-378ea7f5dda59b679be48d6b6df463146bd4097f424731c86fa86b2bc7b8b4623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Autopsy</topic><topic>Cause of Death</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>Chronic diseases</topic><topic>Cross-Sectional Studies</topic><topic>Death</topic><topic>Diagnostic Errors</topic><topic>Humans</topic><topic>Lung Abscess</topic><topic>Male</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Original</topic><topic>Pneumonia</topic><topic>Retrospective Studies</topic><topic>Saccharomyces cerevisiae</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribeiro, Maira P.</creatorcontrib><creatorcontrib>Duarte-Neto, Amaro N.</creatorcontrib><creatorcontrib>Dolhnikoff, Marisa</creatorcontrib><creatorcontrib>Lindoso, Livia</creatorcontrib><creatorcontrib>Lourenço, Benito</creatorcontrib><creatorcontrib>Marques, Heloisa H.</creatorcontrib><creatorcontrib>Pereira, Maria F.B.</creatorcontrib><creatorcontrib>Cristofani, Lilian M.</creatorcontrib><creatorcontrib>Odone-Filho, Vicente</creatorcontrib><creatorcontrib>Campos, Lucia M.A.</creatorcontrib><creatorcontrib>Sallum, Adriana M.E.</creatorcontrib><creatorcontrib>Carneiro-Sampaio, Magda</creatorcontrib><creatorcontrib>Delgado, Artur F.</creatorcontrib><creatorcontrib>Carvalho, Werther B.</creatorcontrib><creatorcontrib>Mauad, Thais</creatorcontrib><creatorcontrib>Silva, Clovis A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><jtitle>Clinics (São Paulo, Brazil)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribeiro, Maira P.</au><au>Duarte-Neto, Amaro N.</au><au>Dolhnikoff, Marisa</au><au>Lindoso, Livia</au><au>Lourenço, Benito</au><au>Marques, Heloisa H.</au><au>Pereira, Maria F.B.</au><au>Cristofani, Lilian M.</au><au>Odone-Filho, Vicente</au><au>Campos, Lucia M.A.</au><au>Sallum, Adriana M.E.</au><au>Carneiro-Sampaio, Magda</au><au>Delgado, Artur F.</au><au>Carvalho, Werther B.</au><au>Mauad, Thais</au><au>Silva, Clovis A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years</atitle><jtitle>Clinics (São Paulo, Brazil)</jtitle><addtitle>Clinics (Sao Paulo)</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>78</volume><spage>100184</spage><epage>100184</epage><pages>100184-100184</pages><artnum>100184</artnum><issn>1807-5932</issn><issn>1980-5322</issn><eissn>1980-5322</eissn><abstract>• Evaluation of disagreement between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.• 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings, mainly caused by infections.• Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were identified at autopsy findings in the groups with major discrepancies.
To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.
A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59).
Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018).
This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.</abstract><cop>United States</cop><pub>Elsevier España, S.L.U</pub><pmid>36972631</pmid><doi>10.1016/j.clinsp.2023.100184</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3452-8789</orcidid><orcidid>https://orcid.org/0000-0002-4535-0894</orcidid><orcidid>https://orcid.org/0000-0002-1924-4043</orcidid><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
subjects | Adolescent Autopsy Cause of Death Child Chronic Disease Chronic diseases Cross-Sectional Studies Death Diagnostic Errors Humans Lung Abscess Male MEDICINE, GENERAL & INTERNAL Original Pneumonia Retrospective Studies Saccharomyces cerevisiae Yeast |
title | Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years |
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