Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years

• Evaluation of disagreement between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.• 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings, mainly caused by infections.• Pneumonia, pulmona...

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Veröffentlicht in:Clinics (São Paulo, Brazil) Brazil), 2023-01, Vol.78, p.100184-100184, Article 100184
Hauptverfasser: Ribeiro, Maira P., Duarte-Neto, Amaro N., Dolhnikoff, Marisa, Lindoso, Livia, Lourenço, Benito, Marques, Heloisa H., Pereira, Maria F.B., Cristofani, Lilian M., Odone-Filho, Vicente, Campos, Lucia M.A., Sallum, Adriana M.E., Carneiro-Sampaio, Magda, Delgado, Artur F., Carvalho, Werther B., Mauad, Thais, Silva, Clovis A.
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container_issue
container_start_page 100184
container_title Clinics (São Paulo, Brazil)
container_volume 78
creator Ribeiro, Maira P.
Duarte-Neto, Amaro N.
Dolhnikoff, Marisa
Lindoso, Livia
Lourenço, Benito
Marques, Heloisa H.
Pereira, Maria F.B.
Cristofani, Lilian M.
Odone-Filho, Vicente
Campos, Lucia M.A.
Sallum, Adriana M.E.
Carneiro-Sampaio, Magda
Delgado, Artur F.
Carvalho, Werther B.
Mauad, Thais
Silva, Clovis A.
description • Evaluation of disagreement between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.• 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings, mainly caused by infections.• Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were identified at autopsy findings in the groups with major discrepancies. To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases. A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59). Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018). This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.
doi_str_mv 10.1016/j.clinsp.2023.100184
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To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases. A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59). Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018). This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.</description><identifier>ISSN: 1807-5932</identifier><identifier>ISSN: 1980-5322</identifier><identifier>EISSN: 1980-5322</identifier><identifier>DOI: 10.1016/j.clinsp.2023.100184</identifier><identifier>PMID: 36972631</identifier><language>eng</language><publisher>United States: Elsevier España, S.L.U</publisher><subject>Adolescent ; Autopsy ; Cause of Death ; Child ; Chronic Disease ; Chronic diseases ; Cross-Sectional Studies ; Death ; Diagnostic Errors ; Humans ; Lung Abscess ; Male ; MEDICINE, GENERAL &amp; INTERNAL ; Original ; Pneumonia ; Retrospective Studies ; Saccharomyces cerevisiae ; Yeast</subject><ispartof>Clinics (São Paulo, Brazil), 2023-01, Vol.78, p.100184-100184, Article 100184</ispartof><rights>2023 HCFMUSP</rights><rights>Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.</rights><rights>2023 HCFMUSP. Published by Elsevier España, S.L.U. 2023 HCFMUSP</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-378ea7f5dda59b679be48d6b6df463146bd4097f424731c86fa86b2bc7b8b4623</citedby><cites>FETCH-LOGICAL-c503t-378ea7f5dda59b679be48d6b6df463146bd4097f424731c86fa86b2bc7b8b4623</cites><orcidid>0000-0003-3452-8789 ; 0000-0002-4535-0894 ; 0000-0002-1924-4043</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091384/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091384/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36972631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro, Maira P.</creatorcontrib><creatorcontrib>Duarte-Neto, Amaro N.</creatorcontrib><creatorcontrib>Dolhnikoff, Marisa</creatorcontrib><creatorcontrib>Lindoso, Livia</creatorcontrib><creatorcontrib>Lourenço, Benito</creatorcontrib><creatorcontrib>Marques, Heloisa H.</creatorcontrib><creatorcontrib>Pereira, Maria F.B.</creatorcontrib><creatorcontrib>Cristofani, Lilian M.</creatorcontrib><creatorcontrib>Odone-Filho, Vicente</creatorcontrib><creatorcontrib>Campos, Lucia M.A.</creatorcontrib><creatorcontrib>Sallum, Adriana M.E.</creatorcontrib><creatorcontrib>Carneiro-Sampaio, Magda</creatorcontrib><creatorcontrib>Delgado, Artur F.</creatorcontrib><creatorcontrib>Carvalho, Werther B.</creatorcontrib><creatorcontrib>Mauad, Thais</creatorcontrib><creatorcontrib>Silva, Clovis A.</creatorcontrib><title>Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years</title><title>Clinics (São Paulo, Brazil)</title><addtitle>Clinics (Sao Paulo)</addtitle><description>• Evaluation of disagreement between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.• 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings, mainly caused by infections.• Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were identified at autopsy findings in the groups with major discrepancies. To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases. A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59). Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018). This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.</description><subject>Adolescent</subject><subject>Autopsy</subject><subject>Cause of Death</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Chronic diseases</subject><subject>Cross-Sectional Studies</subject><subject>Death</subject><subject>Diagnostic Errors</subject><subject>Humans</subject><subject>Lung Abscess</subject><subject>Male</subject><subject>MEDICINE, GENERAL &amp; INTERNAL</subject><subject>Original</subject><subject>Pneumonia</subject><subject>Retrospective Studies</subject><subject>Saccharomyces cerevisiae</subject><subject>Yeast</subject><issn>1807-5932</issn><issn>1980-5322</issn><issn>1980-5322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuO1DAQjBCIfcAfIOQjlwx-JbEvILSCBWkRB-BsOXZnxlHGDnayq_kGfhqbLCu4cPCzq6q7q6vqBcE7gkn7etyZyfk07yimLH9hIvij6pxIgeuGUfo43wXu6kYyelZdpDRizCTjzdPqjLWyoy0j59XPz3oMEVmXTIRZe3NCPSx3AB4VeWf0lIN670NyCYUBWdDLAWlv89JLOIY5v8MU9r-hg_PW-X1CziNtwwTJgF8SunOZZA4xZMWSDHSChOwaMxgRUZ9Ax_SsejLoKcHz-_Oy-v7h_berj_XNl-tPV-9uatNgttSsE6C7obFWN7JvO9kDF7btWzvw3BNve8ux7AZOeceIEe2gRdvT3nS96HlL2WW123STcTAFNYY1-pxQfS2GqWJY8RRnSzGmVGbC240wr_0RbGkp6knN0R11PKmgnfo34t1B7cOtynxJmOBZ4dW9Qgw_VkiLOmbHYZq0h7AmRTtJucxbqY5vUBNDShGGhzwEqzJ5Napt8qpUqbbJZ9rLv2t8IP0ZdQa82QCQrb11EFVp3xuwLoJZlA3u_xl-AeDawtA</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Ribeiro, Maira P.</creator><creator>Duarte-Neto, Amaro N.</creator><creator>Dolhnikoff, Marisa</creator><creator>Lindoso, Livia</creator><creator>Lourenço, Benito</creator><creator>Marques, Heloisa H.</creator><creator>Pereira, Maria F.B.</creator><creator>Cristofani, Lilian M.</creator><creator>Odone-Filho, Vicente</creator><creator>Campos, Lucia M.A.</creator><creator>Sallum, Adriana M.E.</creator><creator>Carneiro-Sampaio, Magda</creator><creator>Delgado, Artur F.</creator><creator>Carvalho, Werther B.</creator><creator>Mauad, Thais</creator><creator>Silva, Clovis A.</creator><general>Elsevier España, S.L.U</general><general>Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo</general><general>Faculdade de Medicina / USP</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><orcidid>https://orcid.org/0000-0003-3452-8789</orcidid><orcidid>https://orcid.org/0000-0002-4535-0894</orcidid><orcidid>https://orcid.org/0000-0002-1924-4043</orcidid></search><sort><creationdate>20230101</creationdate><title>Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years</title><author>Ribeiro, Maira P. ; 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To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases. A cross-sectional study including a sample of adolescents’ autopsies who died in a pediatric and adolescent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59). Median age at death (13.5 [10‒19] vs. 13 [10‒19] years, p = 0.495) and disease duration (22 [0‒164] vs. 20 [0‒200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018). This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.</abstract><cop>United States</cop><pub>Elsevier España, S.L.U</pub><pmid>36972631</pmid><doi>10.1016/j.clinsp.2023.100184</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3452-8789</orcidid><orcidid>https://orcid.org/0000-0002-4535-0894</orcidid><orcidid>https://orcid.org/0000-0002-1924-4043</orcidid><oa>free_for_read</oa></addata></record>
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issn 1807-5932
1980-5322
1980-5322
language eng
recordid cdi_scielo_journals_S1807_59322023000100229
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection
subjects Adolescent
Autopsy
Cause of Death
Child
Chronic Disease
Chronic diseases
Cross-Sectional Studies
Death
Diagnostic Errors
Humans
Lung Abscess
Male
MEDICINE, GENERAL & INTERNAL
Original
Pneumonia
Retrospective Studies
Saccharomyces cerevisiae
Yeast
title Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years
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