Diagnosis of parapneumonic pleural effusion with serum and pleural fluid Activin A
•Higher concentrations of Activin A in pleural effusion were associated with days of admission in PPE patients.•Elevated levels of Activin A in pleural effusion exhibited 93% sensitivity and 84% specificity in the diagnosis of PPE.•Pleural fluid Activin A level had higher AUC and better accuracy in...
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| Veröffentlicht in: | Clinics (São Paulo, Brazil) Brazil), 2022-01, Vol.77, p.100133-100133, Article 100133 |
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| container_title | Clinics (São Paulo, Brazil) |
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| creator | Zhou, Guanghui Liu, Kan Ji, Xiuhai Fen, Yan Gu, Yinjie Ding, Hui |
| description | •Higher concentrations of Activin A in pleural effusion were associated with days of admission in PPE patients.•Elevated levels of Activin A in pleural effusion exhibited 93% sensitivity and 84% specificity in the diagnosis of PPE.•Pleural fluid Activin A level had higher AUC and better accuracy in the diagnosis of PPE.
The aim is to evaluate the diagnostic value of Activin A levels in serum and pleural fluid on Parapneumonic Pleural Effusion (PPE).
The authors collected serum and pleural fluid from 86 PPE and 37 Non-PPE (NPPE) patients. Including Activin A, levels of biomarkers such as Lactate Dehydrogenase (LDH), Procalcitonin (PCT), and C-Reactive Protein (CRP) were measured. All factors were calculated for association with days after admission. The diagnostic potential of biomarkers on PPE was considered by Receiver Operating Characteristic (ROC) curve analysis.
Levels of Activin A in serum and pleural fluid of PPE patients were significantly higher than those of the NPPE patients. Moreover, concentrations of Activin A in pleural fluid showed a more obvious relevant days after admission. ROC curve analysis found that Activin A in pleural fluid had AUCs of 0.899 with 93% sensitivity and 84% specificity for PPE diagnosis.
Activin A in pleural fluid correlated with disease severity could act to diagnose PPE. |
| doi_str_mv | 10.1016/j.clinsp.2022.100133 |
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The aim is to evaluate the diagnostic value of Activin A levels in serum and pleural fluid on Parapneumonic Pleural Effusion (PPE).
The authors collected serum and pleural fluid from 86 PPE and 37 Non-PPE (NPPE) patients. Including Activin A, levels of biomarkers such as Lactate Dehydrogenase (LDH), Procalcitonin (PCT), and C-Reactive Protein (CRP) were measured. All factors were calculated for association with days after admission. The diagnostic potential of biomarkers on PPE was considered by Receiver Operating Characteristic (ROC) curve analysis.
Levels of Activin A in serum and pleural fluid of PPE patients were significantly higher than those of the NPPE patients. Moreover, concentrations of Activin A in pleural fluid showed a more obvious relevant days after admission. ROC curve analysis found that Activin A in pleural fluid had AUCs of 0.899 with 93% sensitivity and 84% specificity for PPE diagnosis.
Activin A in pleural fluid correlated with disease severity could act to diagnose PPE.</description><identifier>ISSN: 1807-5932</identifier><identifier>ISSN: 1980-5322</identifier><identifier>EISSN: 1980-5322</identifier><identifier>DOI: 10.1016/j.clinsp.2022.100133</identifier><identifier>PMID: 36375297</identifier><language>eng</language><publisher>United States: Elsevier España, S.L.U</publisher><subject>Activin A ; Biomarkers - metabolism ; Diagnosis, Differential ; Exudates and Transudates - metabolism ; Humans ; MEDICINE, GENERAL & INTERNAL ; Original ; Parapneumonia ; Pleura ; Pleural Effusion - diagnosis ; Pleural fluid ; ROC Curve ; Serum</subject><ispartof>Clinics (São Paulo, Brazil), 2022-01, Vol.77, p.100133-100133, Article 100133</ispartof><rights>2022 HCFMUSP</rights><rights>Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.</rights><rights>2022 HCFMUSP. Published by Elsevier España, S.L.U. 2022 HCFMUSP</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c451t-e824713f605546a258fc353c534ef9fbe730ede5c4a9034bf5268576f5fe07883</cites><orcidid>0000-0002-6112-3755 ; 0000-0003-2477-461X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661670/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661670/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36375297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Guanghui</creatorcontrib><creatorcontrib>Liu, Kan</creatorcontrib><creatorcontrib>Ji, Xiuhai</creatorcontrib><creatorcontrib>Fen, Yan</creatorcontrib><creatorcontrib>Gu, Yinjie</creatorcontrib><creatorcontrib>Ding, Hui</creatorcontrib><title>Diagnosis of parapneumonic pleural effusion with serum and pleural fluid Activin A</title><title>Clinics (São Paulo, Brazil)</title><addtitle>Clinics (Sao Paulo)</addtitle><description>•Higher concentrations of Activin A in pleural effusion were associated with days of admission in PPE patients.•Elevated levels of Activin A in pleural effusion exhibited 93% sensitivity and 84% specificity in the diagnosis of PPE.•Pleural fluid Activin A level had higher AUC and better accuracy in the diagnosis of PPE.
The aim is to evaluate the diagnostic value of Activin A levels in serum and pleural fluid on Parapneumonic Pleural Effusion (PPE).
The authors collected serum and pleural fluid from 86 PPE and 37 Non-PPE (NPPE) patients. Including Activin A, levels of biomarkers such as Lactate Dehydrogenase (LDH), Procalcitonin (PCT), and C-Reactive Protein (CRP) were measured. All factors were calculated for association with days after admission. The diagnostic potential of biomarkers on PPE was considered by Receiver Operating Characteristic (ROC) curve analysis.
Levels of Activin A in serum and pleural fluid of PPE patients were significantly higher than those of the NPPE patients. Moreover, concentrations of Activin A in pleural fluid showed a more obvious relevant days after admission. ROC curve analysis found that Activin A in pleural fluid had AUCs of 0.899 with 93% sensitivity and 84% specificity for PPE diagnosis.
Activin A in pleural fluid correlated with disease severity could act to diagnose PPE.</description><subject>Activin A</subject><subject>Biomarkers - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Exudates and Transudates - metabolism</subject><subject>Humans</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Original</subject><subject>Parapneumonia</subject><subject>Pleura</subject><subject>Pleural Effusion - diagnosis</subject><subject>Pleural fluid</subject><subject>ROC Curve</subject><subject>Serum</subject><issn>1807-5932</issn><issn>1980-5322</issn><issn>1980-5322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuO1DAQjBCIXRb-ACEfuWTw28kFabQ8pZWQeJwtj9Pe9Sixgx0P4u9xlGWAC77Y6nZVdXU1zXOCdwQT-eq4s6MPed5RTGktYcLYg-aS9B1uBaP0YX13WLWiZ_SieZLzEWPWMy4eNxdMMiVory6bz2-8uQ0x-4yiQ7NJZg5Qphi8RfMIJZkRgXMl-xjQD7_coQypTMiE4dx3Y_ED2tvFn3xA-6fNI2fGDM_u76vm27u3X68_tDef3n-83t-0lguytNBRrghzEgvBpaGic5YJZgXj4Hp3AMUwDCAsNz1m_OAElZ1Q0gkHWHUdu2p2G2-2Hsaoj7GkUAX1l9W3Xn2vq8F1MxjTnlfA6w0wl8MEg4Ww1PH1nPxk0k8djdf_doK_07fxpHspiVS4Ery8J0jxe4G86MlnC-NoAsSSNVVM1tOrVYtvX22KOSdwZxmC9ZqfPuotP70Oqbf8KuzF3yOeQb8D--MB6mZPHpJe3QcLg09gFz1E_3-FXzyLrEk</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Zhou, Guanghui</creator><creator>Liu, Kan</creator><creator>Ji, Xiuhai</creator><creator>Fen, Yan</creator><creator>Gu, Yinjie</creator><creator>Ding, Hui</creator><general>Elsevier España, S.L.U</general><general>Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo</general><general>Faculdade de Medicina / USP</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><orcidid>https://orcid.org/0000-0002-6112-3755</orcidid><orcidid>https://orcid.org/0000-0003-2477-461X</orcidid></search><sort><creationdate>20220101</creationdate><title>Diagnosis of parapneumonic pleural effusion with serum and pleural fluid Activin A</title><author>Zhou, Guanghui ; Liu, Kan ; Ji, Xiuhai ; Fen, Yan ; Gu, Yinjie ; Ding, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-e824713f605546a258fc353c534ef9fbe730ede5c4a9034bf5268576f5fe07883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Activin A</topic><topic>Biomarkers - metabolism</topic><topic>Diagnosis, Differential</topic><topic>Exudates and Transudates - metabolism</topic><topic>Humans</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Original</topic><topic>Parapneumonia</topic><topic>Pleura</topic><topic>Pleural Effusion - diagnosis</topic><topic>Pleural fluid</topic><topic>ROC Curve</topic><topic>Serum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Guanghui</creatorcontrib><creatorcontrib>Liu, Kan</creatorcontrib><creatorcontrib>Ji, Xiuhai</creatorcontrib><creatorcontrib>Fen, Yan</creatorcontrib><creatorcontrib>Gu, Yinjie</creatorcontrib><creatorcontrib>Ding, Hui</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><jtitle>Clinics (São Paulo, Brazil)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Guanghui</au><au>Liu, Kan</au><au>Ji, Xiuhai</au><au>Fen, Yan</au><au>Gu, Yinjie</au><au>Ding, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of parapneumonic pleural effusion with serum and pleural fluid Activin A</atitle><jtitle>Clinics (São Paulo, Brazil)</jtitle><addtitle>Clinics (Sao Paulo)</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>77</volume><spage>100133</spage><epage>100133</epage><pages>100133-100133</pages><artnum>100133</artnum><issn>1807-5932</issn><issn>1980-5322</issn><eissn>1980-5322</eissn><abstract>•Higher concentrations of Activin A in pleural effusion were associated with days of admission in PPE patients.•Elevated levels of Activin A in pleural effusion exhibited 93% sensitivity and 84% specificity in the diagnosis of PPE.•Pleural fluid Activin A level had higher AUC and better accuracy in the diagnosis of PPE.
The aim is to evaluate the diagnostic value of Activin A levels in serum and pleural fluid on Parapneumonic Pleural Effusion (PPE).
The authors collected serum and pleural fluid from 86 PPE and 37 Non-PPE (NPPE) patients. Including Activin A, levels of biomarkers such as Lactate Dehydrogenase (LDH), Procalcitonin (PCT), and C-Reactive Protein (CRP) were measured. All factors were calculated for association with days after admission. The diagnostic potential of biomarkers on PPE was considered by Receiver Operating Characteristic (ROC) curve analysis.
Levels of Activin A in serum and pleural fluid of PPE patients were significantly higher than those of the NPPE patients. Moreover, concentrations of Activin A in pleural fluid showed a more obvious relevant days after admission. ROC curve analysis found that Activin A in pleural fluid had AUCs of 0.899 with 93% sensitivity and 84% specificity for PPE diagnosis.
Activin A in pleural fluid correlated with disease severity could act to diagnose PPE.</abstract><cop>United States</cop><pub>Elsevier España, S.L.U</pub><pmid>36375297</pmid><doi>10.1016/j.clinsp.2022.100133</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6112-3755</orcidid><orcidid>https://orcid.org/0000-0003-2477-461X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Activin A Biomarkers - metabolism Diagnosis, Differential Exudates and Transudates - metabolism Humans MEDICINE, GENERAL & INTERNAL Original Parapneumonia Pleura Pleural Effusion - diagnosis Pleural fluid ROC Curve Serum |
| title | Diagnosis of parapneumonic pleural effusion with serum and pleural fluid Activin A |
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