Clinical and laboratory parameters as predictors of long-term outcome according to the etiology of underlying chronic liver disease in patients who underwent liver transplantation for hepatocellular carcinoma treatment
This study aimed to analyze clinical and laboratory parameters and their association with long-term outcomes in patients who underwent liver transplantation for hepatocellular carcinoma treatment, according to the etiology of the underlying chronic liver disease, in order to identify predictors of r...
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| container_title | Clinics (São Paulo, Brazil) |
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| creator | Diniz, Paulo Henrique Costa Silva, Serena Dafne do Carmo Faria, Luciana Costa Vidigal, Paula Vieira Teixeira Ferrari, Teresa Cristina de Abreu |
| description | This study aimed to analyze clinical and laboratory parameters and their association with long-term outcomes in patients who underwent liver transplantation for hepatocellular carcinoma treatment, according to the etiology of the underlying chronic liver disease, in order to identify predictors of response to this therapeutic modality.
Demographic, clinical, and laboratory data from a cohort of 134 patients who underwent orthotopic liver transplantation for hepatocellular carcinoma treatment at a referral center in Brazil were retrospectively selected and compared according to the etiologic group of the underlying chronic liver disease. Events, defined as tumor recurrence or death from any cause, and event-free survival were also analyzed, and multivariate analysis was performed.
The etiologies comprised hepatitis C and B virus infection, alcohol abuse, and cryptogenic disorder. Although liver transplantation was performed outside the Milan criteria in 33.3% of the subjects, according to pathologic examination of the explanted liver, the Model for End-Stage Liver Disease score was low ( |
| doi_str_mv | 10.6061/clinics/2020/e1529 |
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Demographic, clinical, and laboratory data from a cohort of 134 patients who underwent orthotopic liver transplantation for hepatocellular carcinoma treatment at a referral center in Brazil were retrospectively selected and compared according to the etiologic group of the underlying chronic liver disease. Events, defined as tumor recurrence or death from any cause, and event-free survival were also analyzed, and multivariate analysis was performed.
The etiologies comprised hepatitis C and B virus infection, alcohol abuse, and cryptogenic disorder. Although liver transplantation was performed outside the Milan criteria in 33.3% of the subjects, according to pathologic examination of the explanted liver, the Model for End-Stage Liver Disease score was low (<22) in most patients (70.6%) and recurrence was identified in only 10 (7.9%) patients. Events occurred in 37 patients (28.5%), and the median event-free survival was 75 months (range, 24-116 months). No difference among etiologic groups was found in the parameters analyzed, which were not independently associated with outcome.
Clinical and laboratory characteristics according to etiologic groups were not different, which might have led to comparable long-term outcomes among these patient groups and failure to identify predictors that could aid in better selection of subjects for liver transplantation in the management of this cancer.</description><identifier>ISSN: 1807-5932</identifier><identifier>ISSN: 1980-5322</identifier><identifier>EISSN: 1980-5322</identifier><identifier>DOI: 10.6061/clinics/2020/e1529</identifier><identifier>PMID: 32520221</identifier><language>eng</language><publisher>Elsevier España, S.L.U</publisher><subject>Hepatocellular Carcinoma ; Liver Cirrhosis ; Liver Transplantation ; MEDICINE, GENERAL & INTERNAL ; Original ; Recurrence</subject><ispartof>Clinics (São Paulo, Brazil), 2020, Vol.75, p.e1529-e1529, Article e1529</ispartof><rights>2020 CLINICS</rights><rights>Copyright © 2020 CLINICS 2020</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c488t-3f4056a791aff7a4ed4a7f786a0e89f70bdaac92b1e6cca6a1ee722f80b5b7503</cites><orcidid>0000-0001-9459-2294 ; 0000-0002-7003-5159 ; 0000-0002-6705-0323 ; 0000-0002-0226-3491 ; 0000-0003-2016-5593</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247738/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247738/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,4010,27900,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Diniz, Paulo Henrique Costa</creatorcontrib><creatorcontrib>Silva, Serena Dafne do Carmo</creatorcontrib><creatorcontrib>Faria, Luciana Costa</creatorcontrib><creatorcontrib>Vidigal, Paula Vieira Teixeira</creatorcontrib><creatorcontrib>Ferrari, Teresa Cristina de Abreu</creatorcontrib><title>Clinical and laboratory parameters as predictors of long-term outcome according to the etiology of underlying chronic liver disease in patients who underwent liver transplantation for hepatocellular carcinoma treatment</title><title>Clinics (São Paulo, Brazil)</title><addtitle>Clinics</addtitle><description>This study aimed to analyze clinical and laboratory parameters and their association with long-term outcomes in patients who underwent liver transplantation for hepatocellular carcinoma treatment, according to the etiology of the underlying chronic liver disease, in order to identify predictors of response to this therapeutic modality.
Demographic, clinical, and laboratory data from a cohort of 134 patients who underwent orthotopic liver transplantation for hepatocellular carcinoma treatment at a referral center in Brazil were retrospectively selected and compared according to the etiologic group of the underlying chronic liver disease. Events, defined as tumor recurrence or death from any cause, and event-free survival were also analyzed, and multivariate analysis was performed.
The etiologies comprised hepatitis C and B virus infection, alcohol abuse, and cryptogenic disorder. Although liver transplantation was performed outside the Milan criteria in 33.3% of the subjects, according to pathologic examination of the explanted liver, the Model for End-Stage Liver Disease score was low (<22) in most patients (70.6%) and recurrence was identified in only 10 (7.9%) patients. Events occurred in 37 patients (28.5%), and the median event-free survival was 75 months (range, 24-116 months). No difference among etiologic groups was found in the parameters analyzed, which were not independently associated with outcome.
Clinical and laboratory characteristics according to etiologic groups were not different, which might have led to comparable long-term outcomes among these patient groups and failure to identify predictors that could aid in better selection of subjects for liver transplantation in the management of this cancer.</description><subject>Hepatocellular Carcinoma</subject><subject>Liver Cirrhosis</subject><subject>Liver Transplantation</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Original</subject><subject>Recurrence</subject><issn>1807-5932</issn><issn>1980-5322</issn><issn>1980-5322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9Uk2P0zAQjRCIXQp_gJOPXLp1nA8nEkJC1QIrrcQBOFsTZ9K6cjzFdrrqX-XX4DQV0l7wxR_z3psZz8uy9zm_q3mdb7Q1zuiwEVzwDeaVaF9kt3nb8HVVCPEynRsu11VbiJvsTQgHzou2KKvX2U0hqkQS-W32Z3sRAcvA9cxCRx4i-TM7gocRI_rAILCjx97oFAiMBmbJ7dYpNDKaoqYRGWhNvjduxyKxuEeG0ZCl3XmGT65Hb89zVO89pXTMmhN61puAEJAZl9JFgy4G9rSnhfCUrldc9ODC0YKLCUWODeTZHhOFNFo7WfBMg9fG0QgJjBDHRH6bvRrABnx33VfZry_3P7ff1o_fvz5sPz-uddk0cV0MJa9qkG0OwyChxL4EOcimBo5NO0je9QC6FV2OtdZQQ44ohRga3lWdrHixyh4W3Z7goI7ejODPisCoywP5nQIfjbaoQEJd8L4sugbKoinatsROyDlBWeumT1p3i1bQBi2pA03epeLVj3mWap7lPO20cs5FIRPh00I4Tt2IvU59e7DPqngecWavdnRSUpRSphJW2YergKffE4aoRhPmbwWHNAUlyjw5qyl5nqBigWpPIXgc_qXJuZodqa6OVHON6uLIRPq4kDCN4GTQq7k1p5OfPOqY_sj8j_4X_dfwvg</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Diniz, Paulo Henrique Costa</creator><creator>Silva, Serena Dafne do Carmo</creator><creator>Faria, Luciana Costa</creator><creator>Vidigal, Paula Vieira Teixeira</creator><creator>Ferrari, Teresa Cristina de Abreu</creator><general>Elsevier España, S.L.U</general><general>Faculdade de Medicina / USP</general><general>Elsevier España</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9459-2294</orcidid><orcidid>https://orcid.org/0000-0002-7003-5159</orcidid><orcidid>https://orcid.org/0000-0002-6705-0323</orcidid><orcidid>https://orcid.org/0000-0002-0226-3491</orcidid><orcidid>https://orcid.org/0000-0003-2016-5593</orcidid></search><sort><creationdate>2020</creationdate><title>Clinical and laboratory parameters as predictors of long-term outcome according to the etiology of underlying chronic liver disease in patients who underwent liver transplantation for hepatocellular carcinoma treatment</title><author>Diniz, Paulo Henrique Costa ; Silva, Serena Dafne do Carmo ; Faria, Luciana Costa ; Vidigal, Paula Vieira Teixeira ; Ferrari, Teresa Cristina de Abreu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-3f4056a791aff7a4ed4a7f786a0e89f70bdaac92b1e6cca6a1ee722f80b5b7503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Hepatocellular Carcinoma</topic><topic>Liver Cirrhosis</topic><topic>Liver Transplantation</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Original</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diniz, Paulo Henrique Costa</creatorcontrib><creatorcontrib>Silva, Serena Dafne do Carmo</creatorcontrib><creatorcontrib>Faria, Luciana Costa</creatorcontrib><creatorcontrib>Vidigal, Paula Vieira Teixeira</creatorcontrib><creatorcontrib>Ferrari, Teresa Cristina de Abreu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Clinics (São Paulo, Brazil)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diniz, Paulo Henrique Costa</au><au>Silva, Serena Dafne do Carmo</au><au>Faria, Luciana Costa</au><au>Vidigal, Paula Vieira Teixeira</au><au>Ferrari, Teresa Cristina de Abreu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and laboratory parameters as predictors of long-term outcome according to the etiology of underlying chronic liver disease in patients who underwent liver transplantation for hepatocellular carcinoma treatment</atitle><jtitle>Clinics (São Paulo, Brazil)</jtitle><addtitle>Clinics</addtitle><date>2020</date><risdate>2020</risdate><volume>75</volume><spage>e1529</spage><epage>e1529</epage><pages>e1529-e1529</pages><artnum>e1529</artnum><issn>1807-5932</issn><issn>1980-5322</issn><eissn>1980-5322</eissn><abstract>This study aimed to analyze clinical and laboratory parameters and their association with long-term outcomes in patients who underwent liver transplantation for hepatocellular carcinoma treatment, according to the etiology of the underlying chronic liver disease, in order to identify predictors of response to this therapeutic modality.
Demographic, clinical, and laboratory data from a cohort of 134 patients who underwent orthotopic liver transplantation for hepatocellular carcinoma treatment at a referral center in Brazil were retrospectively selected and compared according to the etiologic group of the underlying chronic liver disease. Events, defined as tumor recurrence or death from any cause, and event-free survival were also analyzed, and multivariate analysis was performed.
The etiologies comprised hepatitis C and B virus infection, alcohol abuse, and cryptogenic disorder. Although liver transplantation was performed outside the Milan criteria in 33.3% of the subjects, according to pathologic examination of the explanted liver, the Model for End-Stage Liver Disease score was low (<22) in most patients (70.6%) and recurrence was identified in only 10 (7.9%) patients. Events occurred in 37 patients (28.5%), and the median event-free survival was 75 months (range, 24-116 months). No difference among etiologic groups was found in the parameters analyzed, which were not independently associated with outcome.
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| ispartof | Clinics (São Paulo, Brazil), 2020, Vol.75, p.e1529-e1529, Article e1529 |
| issn | 1807-5932 1980-5322 1980-5322 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Hepatocellular Carcinoma Liver Cirrhosis Liver Transplantation MEDICINE, GENERAL & INTERNAL Original Recurrence |
| title | Clinical and laboratory parameters as predictors of long-term outcome according to the etiology of underlying chronic liver disease in patients who underwent liver transplantation for hepatocellular carcinoma treatment |
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