Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study
Colorectal cancer is one of the most frequent types of malignant neoplasms. Age is a risk factor for this disease, with 75% of cases diagnosed in patients older than 65 years. Complications such as obstruction, hemorrhage, and perforation are present in more than one-third of cases and require emerg...
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creator | Menegozzo, Carlos Augusto Metidieri Teixeira-Júnior, Frederico do Couto-Netto, Sérgio Dias Martins-Júnior, Octacílio de Oliveira Bernini, Celso Utiyama, Edivaldo Massazo |
description | Colorectal cancer is one of the most frequent types of malignant neoplasms. Age is a risk factor for this disease, with 75% of cases diagnosed in patients older than 65 years. Complications such as obstruction, hemorrhage, and perforation are present in more than one-third of cases and require emergency treatment. We aim to analyze the profile of elderly patients undergoing surgery for complicated colorectal cancer, and to evaluate factors related to worse short-term prognosis.
A retrospective analysis of patients who underwent emergency surgical treatment for complicated colorectal cancer was performed. Demographics, clinical, radiological and histological data were collected.
Sixty-seven patients were analyzed. The median age was 72 years, and almost half (46%) of the patients were female. Obstruction was the most prevalent complication at initial presentation (72%). The most common sites of neoplasia were the left and sigmoid colon in 22 patients (32.8%), and the right colon in 17 patients (25.4%). Resection was performed in 88% of cases, followed by primary anastomosis in almost half. The most frequent clinical stages were II (48%) and III (22%). Forty-three patients (65.7%) had some form of postoperative complication. Clavien-Dindo grades 1, 2, and 4, were the most frequent. Complete oncologic resection was observed in 80% of the cases. The thirty-day mortality rate was 10.4%. Advanced age was associated with worse morbidity and mortality.
Elderly patients with complicated colorectal cancer undergoing emergency surgery have high morbidity and mortality rates. Advanced age is significantly associated with worse outcomes. |
doi_str_mv | 10.6061/clinics/2019/e1074 |
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A retrospective analysis of patients who underwent emergency surgical treatment for complicated colorectal cancer was performed. Demographics, clinical, radiological and histological data were collected.
Sixty-seven patients were analyzed. The median age was 72 years, and almost half (46%) of the patients were female. Obstruction was the most prevalent complication at initial presentation (72%). The most common sites of neoplasia were the left and sigmoid colon in 22 patients (32.8%), and the right colon in 17 patients (25.4%). Resection was performed in 88% of cases, followed by primary anastomosis in almost half. The most frequent clinical stages were II (48%) and III (22%). Forty-three patients (65.7%) had some form of postoperative complication. Clavien-Dindo grades 1, 2, and 4, were the most frequent. Complete oncologic resection was observed in 80% of the cases. The thirty-day mortality rate was 10.4%. Advanced age was associated with worse morbidity and mortality.
Elderly patients with complicated colorectal cancer undergoing emergency surgery have high morbidity and mortality rates. Advanced age is significantly associated with worse outcomes.</description><identifier>ISSN: 1807-5932</identifier><identifier>ISSN: 1980-5322</identifier><identifier>EISSN: 1980-5322</identifier><identifier>DOI: 10.6061/clinics/2019/e1074</identifier><identifier>PMID: 31433041</identifier><language>eng</language><publisher>Brazil: Elsevier España, S.L.U</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Brazil ; Colorectal Neoplasms ; Colorectal Neoplasms - complications ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Colorectal Surgery ; Comorbidity ; Elderly ; Emergency Treatment ; Emergency Treatment - mortality ; Female ; General Surgery ; Humans ; Intensive Care Units - statistics & numerical data ; Length of Stay ; Male ; MEDICINE, GENERAL & INTERNAL ; Middle Aged ; Neoplasm Staging ; Original ; Postoperative Complications ; Postoperative Complications - mortality ; Prognosis ; Retrospective Studies ; Risk Factors ; Statistics, Nonparametric ; Surgical Oncology</subject><ispartof>Clinics (São Paulo, Brazil), 2019, Vol.74, p.e1074-e1074, Article e1074</ispartof><rights>2019 CLINICS</rights><rights>Copyright © 2019 CLINICS 2019</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-20390bce92fd4f5f8f1916a5e78a7dc7e4a187f9450505916036f6806469d22a3</citedby><cites>FETCH-LOGICAL-c560t-20390bce92fd4f5f8f1916a5e78a7dc7e4a187f9450505916036f6806469d22a3</cites><orcidid>0000-0002-8453-7184 ; 0000-0003-3572-8977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691836/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691836/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,4009,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31433041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Menegozzo, Carlos Augusto Metidieri</creatorcontrib><creatorcontrib>Teixeira-Júnior, Frederico</creatorcontrib><creatorcontrib>do Couto-Netto, Sérgio Dias</creatorcontrib><creatorcontrib>Martins-Júnior, Octacílio</creatorcontrib><creatorcontrib>de Oliveira Bernini, Celso</creatorcontrib><creatorcontrib>Utiyama, Edivaldo Massazo</creatorcontrib><title>Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study</title><title>Clinics (São Paulo, Brazil)</title><addtitle>Clinics (Sao Paulo)</addtitle><description>Colorectal cancer is one of the most frequent types of malignant neoplasms. Age is a risk factor for this disease, with 75% of cases diagnosed in patients older than 65 years. Complications such as obstruction, hemorrhage, and perforation are present in more than one-third of cases and require emergency treatment. We aim to analyze the profile of elderly patients undergoing surgery for complicated colorectal cancer, and to evaluate factors related to worse short-term prognosis.
A retrospective analysis of patients who underwent emergency surgical treatment for complicated colorectal cancer was performed. Demographics, clinical, radiological and histological data were collected.
Sixty-seven patients were analyzed. The median age was 72 years, and almost half (46%) of the patients were female. Obstruction was the most prevalent complication at initial presentation (72%). The most common sites of neoplasia were the left and sigmoid colon in 22 patients (32.8%), and the right colon in 17 patients (25.4%). Resection was performed in 88% of cases, followed by primary anastomosis in almost half. The most frequent clinical stages were II (48%) and III (22%). Forty-three patients (65.7%) had some form of postoperative complication. Clavien-Dindo grades 1, 2, and 4, were the most frequent. Complete oncologic resection was observed in 80% of the cases. The thirty-day mortality rate was 10.4%. Advanced age was associated with worse morbidity and mortality.
Elderly patients with complicated colorectal cancer undergoing emergency surgery have high morbidity and mortality rates. Advanced age is significantly associated with worse outcomes.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brazil</subject><subject>Colorectal Neoplasms</subject><subject>Colorectal Neoplasms - complications</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Colorectal Surgery</subject><subject>Comorbidity</subject><subject>Elderly</subject><subject>Emergency Treatment</subject><subject>Emergency Treatment - mortality</subject><subject>Female</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Intensive Care Units - statistics & numerical data</subject><subject>Length of Stay</subject><subject>Male</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Original</subject><subject>Postoperative Complications</subject><subject>Postoperative Complications - mortality</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Statistics, Nonparametric</subject><subject>Surgical Oncology</subject><issn>1807-5932</issn><issn>1980-5322</issn><issn>1980-5322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9Uk1vEzEQXSEQLYU_wAH5yCWNv9a7RgipigJUqlRE6Nly7NnUlXcdbG-k_fd4m1DRC_LBo5k3z89vpqreE3wpsCBL493gTFpSTOQSCG74i-qcyBYvakbpyxK3uFnUktGz6k1KDxgzyXj9ujpjhDOGOTmvptsxm9BDQqFDa28h-gn90NnBkBO6G0piF9ywQ-u-RDCYCW3GEsQJdSGiVej33hmdwZbYhwgma49WejAQP6Er9BNyDGlf0u4ABXIfYkabPNrpbfWq0z7Bu9N9Ud19Xf9afV_c3H67Xl3dLEwtcF7QIhpvDUjaWd7VXdsRSYSuoWl1Y00DXJO26SSvcTmlhJnoRIsFF9JSqtlFdX3ktUE_qH10vY6TCtqpx0SIO6VjdsaDsk0LkjCj2VZywag2kpO6ZVK3WlioC9flkSsZBz6ohzDGoYhXm9lqNVs9DwNjTDCmdVMavhwb9uO2B2uKq1H7ZyqeVwZ3r3bhoISQpGWiEHw8EcTwe4SUVe-SAe_1AGFMilJJccsZnaH0CDXF8RShe3qGYDUvjDotjJo1qseFKU0f_hX41PJ3Qwrg8xEAZUYHB1HNfy_jtW4edjHR_Y__DxAf0dM</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Menegozzo, Carlos Augusto Metidieri</creator><creator>Teixeira-Júnior, Frederico</creator><creator>do Couto-Netto, Sérgio Dias</creator><creator>Martins-Júnior, Octacílio</creator><creator>de Oliveira Bernini, Celso</creator><creator>Utiyama, Edivaldo Massazo</creator><general>Elsevier España, S.L.U</general><general>Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo</general><general>Faculdade de Medicina / USP</general><general>Elsevier España</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8453-7184</orcidid><orcidid>https://orcid.org/0000-0003-3572-8977</orcidid></search><sort><creationdate>2019</creationdate><title>Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study</title><author>Menegozzo, Carlos Augusto Metidieri ; Teixeira-Júnior, Frederico ; do Couto-Netto, Sérgio Dias ; Martins-Júnior, Octacílio ; de Oliveira Bernini, Celso ; Utiyama, Edivaldo Massazo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-20390bce92fd4f5f8f1916a5e78a7dc7e4a187f9450505916036f6806469d22a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brazil</topic><topic>Colorectal Neoplasms</topic><topic>Colorectal Neoplasms - complications</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Colorectal Surgery</topic><topic>Comorbidity</topic><topic>Elderly</topic><topic>Emergency Treatment</topic><topic>Emergency Treatment - mortality</topic><topic>Female</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Intensive Care Units - statistics & numerical data</topic><topic>Length of Stay</topic><topic>Male</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Original</topic><topic>Postoperative Complications</topic><topic>Postoperative Complications - mortality</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Statistics, Nonparametric</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menegozzo, Carlos Augusto Metidieri</creatorcontrib><creatorcontrib>Teixeira-Júnior, Frederico</creatorcontrib><creatorcontrib>do Couto-Netto, Sérgio Dias</creatorcontrib><creatorcontrib>Martins-Júnior, Octacílio</creatorcontrib><creatorcontrib>de Oliveira Bernini, Celso</creatorcontrib><creatorcontrib>Utiyama, Edivaldo Massazo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Clinics (São Paulo, Brazil)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Menegozzo, Carlos Augusto Metidieri</au><au>Teixeira-Júnior, Frederico</au><au>do Couto-Netto, Sérgio Dias</au><au>Martins-Júnior, Octacílio</au><au>de Oliveira Bernini, Celso</au><au>Utiyama, Edivaldo Massazo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study</atitle><jtitle>Clinics (São Paulo, Brazil)</jtitle><addtitle>Clinics (Sao Paulo)</addtitle><date>2019</date><risdate>2019</risdate><volume>74</volume><spage>e1074</spage><epage>e1074</epage><pages>e1074-e1074</pages><artnum>e1074</artnum><issn>1807-5932</issn><issn>1980-5322</issn><eissn>1980-5322</eissn><abstract>Colorectal cancer is one of the most frequent types of malignant neoplasms. Age is a risk factor for this disease, with 75% of cases diagnosed in patients older than 65 years. Complications such as obstruction, hemorrhage, and perforation are present in more than one-third of cases and require emergency treatment. We aim to analyze the profile of elderly patients undergoing surgery for complicated colorectal cancer, and to evaluate factors related to worse short-term prognosis.
A retrospective analysis of patients who underwent emergency surgical treatment for complicated colorectal cancer was performed. Demographics, clinical, radiological and histological data were collected.
Sixty-seven patients were analyzed. The median age was 72 years, and almost half (46%) of the patients were female. Obstruction was the most prevalent complication at initial presentation (72%). The most common sites of neoplasia were the left and sigmoid colon in 22 patients (32.8%), and the right colon in 17 patients (25.4%). Resection was performed in 88% of cases, followed by primary anastomosis in almost half. The most frequent clinical stages were II (48%) and III (22%). Forty-three patients (65.7%) had some form of postoperative complication. Clavien-Dindo grades 1, 2, and 4, were the most frequent. Complete oncologic resection was observed in 80% of the cases. The thirty-day mortality rate was 10.4%. Advanced age was associated with worse morbidity and mortality.
Elderly patients with complicated colorectal cancer undergoing emergency surgery have high morbidity and mortality rates. Advanced age is significantly associated with worse outcomes.</abstract><cop>Brazil</cop><pub>Elsevier España, S.L.U</pub><pmid>31433041</pmid><doi>10.6061/clinics/2019/e1074</doi><orcidid>https://orcid.org/0000-0002-8453-7184</orcidid><orcidid>https://orcid.org/0000-0003-3572-8977</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Age Factors Aged Aged, 80 and over Brazil Colorectal Neoplasms Colorectal Neoplasms - complications Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Colorectal Surgery Comorbidity Elderly Emergency Treatment Emergency Treatment - mortality Female General Surgery Humans Intensive Care Units - statistics & numerical data Length of Stay Male MEDICINE, GENERAL & INTERNAL Middle Aged Neoplasm Staging Original Postoperative Complications Postoperative Complications - mortality Prognosis Retrospective Studies Risk Factors Statistics, Nonparametric Surgical Oncology |
title | Outcomes of Elderly Patients Undergoing Emergency Surgery for Complicated Colorectal Cancer: A Retrospective Cohort Study |
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