Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats
Abstract Low intensity laser can be used as a promising alternative in the treatment of periodontal disease. Objective The aim of this study was to evaluate low-level laser therapy (LLLT) as an adjuvant treatment for scaling and root planing (SRP) for the treatment of induced periodontitis in simvas...
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| Veröffentlicht in: | Journal of applied oral science 2017-08, Vol.25 (4), p.387-395 |
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| creator | SWERTS, Andressa Araújo SANTOS, Bianca Fernanda Espósito BRUZADELLI, Simone Ribeiro BRIGAGÃO, Maísa Ribeiro Pereira Lima LIMA, Daniela Coelho de FERNANDES, Leandro Araújo |
| description | Abstract Low intensity laser can be used as a promising alternative in the treatment of periodontal disease. Objective The aim of this study was to evaluate low-level laser therapy (LLLT) as an adjuvant treatment for scaling and root planing (SRP) for the treatment of induced periodontitis in simvastatin-modified rats. Material and Methods A total of 180 rats were evenly divided into two groups: Veh – receiving oral administration of polyethylene glycol (vehicle); S – receiving oral administration of Simvastatin. Periodontal disease was induced in both groups at the first mandibular molar. After seven days, the ligature was removed and the animals were divided into subgroups according to the following local treatments: NT – no treatment; SRP – scaling and root planing and irrigation with saline solution; and LLLT ¬– SRP and laser irradiation (660 nm; 0.03 W; 4 J). Ten animals in each subgroup/local treatment were euthanized at 7, 15 and 30 days. Samples of gingival tissue were processed to analyze the tissue oxidative damage and radiographic analysis. Levels of oxidative stress were analyzed by the expressions of Tripeptideglutathione (TG), Malondialdehyde (MDA) and Carbonylated Proteins (CP). Results The animals in S group had higher levels of TG and lower levels of MDA and CP compared with Veh group (p |
| doi_str_mv | 10.1590/1678-7757-2016-0467 |
| format | Article |
| fullrecord | <record><control><sourceid>scielo</sourceid><recordid>TN_cdi_scielo_journals_S1678_77572017000400387</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S1678_77572017000400387</scielo_id><sourcerecordid>S1678_77572017000400387</sourcerecordid><originalsourceid>FETCH-scielo_journals_S1678_775720170004003873</originalsourceid><addsrcrecordid>eNqVjjkOwjAQRV2AxHoCmrmAYbIaagSiJx1FZMhEOEpi5DEIbk-CcgGqv-lLT4hVgOsg2eEmSNVWKpUoGWKQSoxTNRLToU2TiZgxV4hRGKndVFwyR9o31HqwJdD7Qc70SdfQW1vYny8Mk2aC6wfqTh34Ozn9-IBpgU3z0uy1N61sbGFKQwU47XkhxqWumZaDzsX6eMj2J8k3Q7XNK_t0bTfk554u75k7ZIWIcce3VdHfhy-uHE0B</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>SWERTS, Andressa Araújo ; SANTOS, Bianca Fernanda Espósito ; BRUZADELLI, Simone Ribeiro ; BRIGAGÃO, Maísa Ribeiro Pereira Lima ; LIMA, Daniela Coelho de ; FERNANDES, Leandro Araújo</creator><creatorcontrib>SWERTS, Andressa Araújo ; SANTOS, Bianca Fernanda Espósito ; BRUZADELLI, Simone Ribeiro ; BRIGAGÃO, Maísa Ribeiro Pereira Lima ; LIMA, Daniela Coelho de ; FERNANDES, Leandro Araújo</creatorcontrib><description>Abstract Low intensity laser can be used as a promising alternative in the treatment of periodontal disease. Objective The aim of this study was to evaluate low-level laser therapy (LLLT) as an adjuvant treatment for scaling and root planing (SRP) for the treatment of induced periodontitis in simvastatin-modified rats. Material and Methods A total of 180 rats were evenly divided into two groups: Veh – receiving oral administration of polyethylene glycol (vehicle); S – receiving oral administration of Simvastatin. Periodontal disease was induced in both groups at the first mandibular molar. After seven days, the ligature was removed and the animals were divided into subgroups according to the following local treatments: NT – no treatment; SRP – scaling and root planing and irrigation with saline solution; and LLLT ¬– SRP and laser irradiation (660 nm; 0.03 W; 4 J). Ten animals in each subgroup/local treatment were euthanized at 7, 15 and 30 days. Samples of gingival tissue were processed to analyze the tissue oxidative damage and radiographic analysis. Levels of oxidative stress were analyzed by the expressions of Tripeptideglutathione (TG), Malondialdehyde (MDA) and Carbonylated Proteins (CP). Results The animals in S group had higher levels of TG and lower levels of MDA and CP compared with Veh group (p<0.05). Radiographically, in the intragroup analysis Veh and S, LLLT showed lower bone loss (BL) compared with NT and SRP, in all experimental periods (p<0.01). In addition, a lower BL was observed for the animals of Veh group treated with LLLT compared with treatment SRP in the S group, in all experimental periods. Conclusion Within the limits of this study, we can conclude that LLLT was effective as adjuvant treatment for SRP protecting against the occurrence of oxidative tissue damages as well as for reducing alveolar bone loss in experimentally induced periodontitis simvastatin-modified rats.</description><identifier>ISSN: 1678-7765</identifier><identifier>DOI: 10.1590/1678-7757-2016-0467</identifier><language>por</language><publisher>Faculdade De Odontologia De Bauru - USP</publisher><subject>DENTISTRY, ORAL SURGERY & MEDICINE</subject><ispartof>Journal of applied oral science, 2017-08, Vol.25 (4), p.387-395</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27903,27904</link.rule.ids></links><search><creatorcontrib>SWERTS, Andressa Araújo</creatorcontrib><creatorcontrib>SANTOS, Bianca Fernanda Espósito</creatorcontrib><creatorcontrib>BRUZADELLI, Simone Ribeiro</creatorcontrib><creatorcontrib>BRIGAGÃO, Maísa Ribeiro Pereira Lima</creatorcontrib><creatorcontrib>LIMA, Daniela Coelho de</creatorcontrib><creatorcontrib>FERNANDES, Leandro Araújo</creatorcontrib><title>Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats</title><title>Journal of applied oral science</title><addtitle>J. Appl. Oral Sci</addtitle><description>Abstract Low intensity laser can be used as a promising alternative in the treatment of periodontal disease. Objective The aim of this study was to evaluate low-level laser therapy (LLLT) as an adjuvant treatment for scaling and root planing (SRP) for the treatment of induced periodontitis in simvastatin-modified rats. Material and Methods A total of 180 rats were evenly divided into two groups: Veh – receiving oral administration of polyethylene glycol (vehicle); S – receiving oral administration of Simvastatin. Periodontal disease was induced in both groups at the first mandibular molar. After seven days, the ligature was removed and the animals were divided into subgroups according to the following local treatments: NT – no treatment; SRP – scaling and root planing and irrigation with saline solution; and LLLT ¬– SRP and laser irradiation (660 nm; 0.03 W; 4 J). Ten animals in each subgroup/local treatment were euthanized at 7, 15 and 30 days. Samples of gingival tissue were processed to analyze the tissue oxidative damage and radiographic analysis. Levels of oxidative stress were analyzed by the expressions of Tripeptideglutathione (TG), Malondialdehyde (MDA) and Carbonylated Proteins (CP). Results The animals in S group had higher levels of TG and lower levels of MDA and CP compared with Veh group (p<0.05). Radiographically, in the intragroup analysis Veh and S, LLLT showed lower bone loss (BL) compared with NT and SRP, in all experimental periods (p<0.01). In addition, a lower BL was observed for the animals of Veh group treated with LLLT compared with treatment SRP in the S group, in all experimental periods. Conclusion Within the limits of this study, we can conclude that LLLT was effective as adjuvant treatment for SRP protecting against the occurrence of oxidative tissue damages as well as for reducing alveolar bone loss in experimentally induced periodontitis simvastatin-modified rats.</description><subject>DENTISTRY, ORAL SURGERY & MEDICINE</subject><issn>1678-7765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqVjjkOwjAQRV2AxHoCmrmAYbIaagSiJx1FZMhEOEpi5DEIbk-CcgGqv-lLT4hVgOsg2eEmSNVWKpUoGWKQSoxTNRLToU2TiZgxV4hRGKndVFwyR9o31HqwJdD7Qc70SdfQW1vYny8Mk2aC6wfqTh34Ozn9-IBpgU3z0uy1N61sbGFKQwU47XkhxqWumZaDzsX6eMj2J8k3Q7XNK_t0bTfk554u75k7ZIWIcce3VdHfhy-uHE0B</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>SWERTS, Andressa Araújo</creator><creator>SANTOS, Bianca Fernanda Espósito</creator><creator>BRUZADELLI, Simone Ribeiro</creator><creator>BRIGAGÃO, Maísa Ribeiro Pereira Lima</creator><creator>LIMA, Daniela Coelho de</creator><creator>FERNANDES, Leandro Araújo</creator><general>Faculdade De Odontologia De Bauru - USP</general><scope>GPN</scope></search><sort><creationdate>20170801</creationdate><title>Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats</title><author>SWERTS, Andressa Araújo ; SANTOS, Bianca Fernanda Espósito ; BRUZADELLI, Simone Ribeiro ; BRIGAGÃO, Maísa Ribeiro Pereira Lima ; LIMA, Daniela Coelho de ; FERNANDES, Leandro Araújo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-scielo_journals_S1678_775720170004003873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>por</language><creationdate>2017</creationdate><topic>DENTISTRY, ORAL SURGERY & MEDICINE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SWERTS, Andressa Araújo</creatorcontrib><creatorcontrib>SANTOS, Bianca Fernanda Espósito</creatorcontrib><creatorcontrib>BRUZADELLI, Simone Ribeiro</creatorcontrib><creatorcontrib>BRIGAGÃO, Maísa Ribeiro Pereira Lima</creatorcontrib><creatorcontrib>LIMA, Daniela Coelho de</creatorcontrib><creatorcontrib>FERNANDES, Leandro Araújo</creatorcontrib><collection>SciELO</collection><jtitle>Journal of applied oral science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SWERTS, Andressa Araújo</au><au>SANTOS, Bianca Fernanda Espósito</au><au>BRUZADELLI, Simone Ribeiro</au><au>BRIGAGÃO, Maísa Ribeiro Pereira Lima</au><au>LIMA, Daniela Coelho de</au><au>FERNANDES, Leandro Araújo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats</atitle><jtitle>Journal of applied oral science</jtitle><addtitle>J. Appl. Oral Sci</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>25</volume><issue>4</issue><spage>387</spage><epage>395</epage><pages>387-395</pages><issn>1678-7765</issn><abstract>Abstract Low intensity laser can be used as a promising alternative in the treatment of periodontal disease. Objective The aim of this study was to evaluate low-level laser therapy (LLLT) as an adjuvant treatment for scaling and root planing (SRP) for the treatment of induced periodontitis in simvastatin-modified rats. Material and Methods A total of 180 rats were evenly divided into two groups: Veh – receiving oral administration of polyethylene glycol (vehicle); S – receiving oral administration of Simvastatin. Periodontal disease was induced in both groups at the first mandibular molar. After seven days, the ligature was removed and the animals were divided into subgroups according to the following local treatments: NT – no treatment; SRP – scaling and root planing and irrigation with saline solution; and LLLT ¬– SRP and laser irradiation (660 nm; 0.03 W; 4 J). Ten animals in each subgroup/local treatment were euthanized at 7, 15 and 30 days. Samples of gingival tissue were processed to analyze the tissue oxidative damage and radiographic analysis. Levels of oxidative stress were analyzed by the expressions of Tripeptideglutathione (TG), Malondialdehyde (MDA) and Carbonylated Proteins (CP). Results The animals in S group had higher levels of TG and lower levels of MDA and CP compared with Veh group (p<0.05). Radiographically, in the intragroup analysis Veh and S, LLLT showed lower bone loss (BL) compared with NT and SRP, in all experimental periods (p<0.01). In addition, a lower BL was observed for the animals of Veh group treated with LLLT compared with treatment SRP in the S group, in all experimental periods. Conclusion Within the limits of this study, we can conclude that LLLT was effective as adjuvant treatment for SRP protecting against the occurrence of oxidative tissue damages as well as for reducing alveolar bone loss in experimentally induced periodontitis simvastatin-modified rats.</abstract><pub>Faculdade De Odontologia De Bauru - USP</pub><doi>10.1590/1678-7757-2016-0467</doi><oa>free_for_read</oa></addata></record> |
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| subjects | DENTISTRY, ORAL SURGERY & MEDICINE |
| title | Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats |
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