Biopharmaceuticals from microorganisms: from production to purification
The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons...
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| Veröffentlicht in: | Brazilian journal of microbiology 2016-12, Vol.47 (S1), p.51-63 |
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| container_title | Brazilian journal of microbiology |
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| creator | Jozala, Angela Faustino Geraldes, Danilo Costa Tundisi, Louise Lacalendola Feitosa, Valker de Araújo Breyer, Carlos Alexandre Cardoso, Samuel Leite Mazzola, Priscila Gava Oliveira-Nascimento, Laura de Rangel-Yagui, Carlota de Oliveira Magalhães, Pérola de Oliveira Oliveira, Marcos Antonio de Pessoa, Adalberto |
| description | The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals. |
| doi_str_mv | 10.1016/j.bjm.2016.10.007 |
| format | Article |
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Published by Elsevier Editora Ltda. All rights reserved.</rights><rights>Copyright Sociedade Brasileira de Microbiologia 2016</rights><rights>2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. 2016 Sociedade Brasileira de Microbiologia</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-13115ff01e6ce1f3c7b06da6e0a9b0b45027e98720df6094f7116ac5b803dff83</citedby><cites>FETCH-LOGICAL-c617t-13115ff01e6ce1f3c7b06da6e0a9b0b45027e98720df6094f7116ac5b803dff83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156500/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156500/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27838289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jozala, Angela Faustino</creatorcontrib><creatorcontrib>Geraldes, Danilo Costa</creatorcontrib><creatorcontrib>Tundisi, Louise Lacalendola</creatorcontrib><creatorcontrib>Feitosa, Valker de Araújo</creatorcontrib><creatorcontrib>Breyer, Carlos Alexandre</creatorcontrib><creatorcontrib>Cardoso, Samuel Leite</creatorcontrib><creatorcontrib>Mazzola, Priscila Gava</creatorcontrib><creatorcontrib>Oliveira-Nascimento, Laura de</creatorcontrib><creatorcontrib>Rangel-Yagui, Carlota de Oliveira</creatorcontrib><creatorcontrib>Magalhães, Pérola de Oliveira</creatorcontrib><creatorcontrib>Oliveira, Marcos Antonio de</creatorcontrib><creatorcontrib>Pessoa, Adalberto</creatorcontrib><title>Biopharmaceuticals from microorganisms: from production to purification</title><title>Brazilian journal of microbiology</title><addtitle>Braz J Microbiol</addtitle><description>The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. 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In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.</description><subject>Biological Products</subject><subject>biopharmaceutical industry</subject><subject>Biopharmaceuticals</subject><subject>bioprocessing</subject><subject>Biosimilar Pharmaceuticals</subject><subject>Biotechnology</subject><subject>Downstream process</subject><subject>Drug Industry</subject><subject>Fermentation</subject><subject>Fermentation process</subject><subject>Humans</subject><subject>interferons</subject><subject>Microbiological Techniques</subject><subject>MICROBIOLOGY</subject><subject>microorganisms</subject><subject>Pharmaceutical Preparations</subject><subject>Pharmaceutical sciences</subject><subject>purification methods</subject><subject>Recombinant Proteins</subject><subject>Review</subject><subject>somatotropin</subject><subject>Upstream 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| identifier | ISSN: 1517-8382 |
| ispartof | Brazilian journal of microbiology, 2016-12, Vol.47 (S1), p.51-63 |
| issn | 1517-8382 1678-4405 1678-4405 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Biological Products biopharmaceutical industry Biopharmaceuticals bioprocessing Biosimilar Pharmaceuticals Biotechnology Downstream process Drug Industry Fermentation Fermentation process Humans interferons Microbiological Techniques MICROBIOLOGY microorganisms Pharmaceutical Preparations Pharmaceutical sciences purification methods Recombinant Proteins Review somatotropin Upstream process |
| title | Biopharmaceuticals from microorganisms: from production to purification |
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