Analysis of risk factors and clinical manifestations associated with Clostridium difficile disease in Serbian hospitalized patients
Clostridium difficile is the leading cause of infectious diarrhoea in hospitalized patients. The aim of this study was to determine the risk factors important for the development of hospital-acquired Clostridium difficile-associated disease and clinical manifestations of Clostridium difficile-associ...
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| Veröffentlicht in: | Brazilian journal of microbiology 2016-10, Vol.47 (4), p.902-910 |
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| description | Clostridium difficile is the leading cause of infectious diarrhoea in hospitalized patients. The aim of this study was to determine the risk factors important for the development of hospital-acquired Clostridium difficile-associated disease and clinical manifestations of Clostridium difficile-associated disease. The clinical trial group included 37 hospitalized patients who were selected according to the inclusion criteria. A control group of 74 hospitalized patients was individually matched with cases based on hospital, age (within 4 years), sex and month of admission.
Clostridium difficile-associated disease most commonly manifested as diarrhoea (56.76%) and colitis (32%), while in 8.11% of patients, it was diagnosed as pseudomembranous colitis, and in one patient, it was diagnosed as fulminant colitis. Statistically significant associations (p |
| doi_str_mv | 10.1016/j.bjm.2016.07.011 |
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Clostridium difficile-associated disease most commonly manifested as diarrhoea (56.76%) and colitis (32%), while in 8.11% of patients, it was diagnosed as pseudomembranous colitis, and in one patient, it was diagnosed as fulminant colitis. Statistically significant associations (p<0.05) were found with the presence of chronic renal failure, chronic obstructive pulmonary disease, cerebrovascular accident (stroke) and haemodialysis. In this study, it was confirmed that all the groups of antibiotics, except for tetracycline and trimethoprim–sulfamethoxazole, were statistically significant risk factors for Clostridium difficile-associated disease (p<0.05). However, it was difficult to determine the individual role of antibiotics in the development of Clostridium difficile-associated disease. Univariate logistic regression also found that applying antibiotic therapy, the duration of antibiotic therapy, administration of two or more antibiotics to treat infections, administering laxatives and the total number of days spent in the hospital significantly affected the onset of Clostridium difficile-associated disease (p<0.05), and associations were confirmed using the multivariate model for the application of antibiotic therapy (p=0.001), duration of antibiotic treatment (p=0.01), use of laxatives (p=0.01) and total number of days spent in the hospital (p=0.001). In this study of patients with hospital-acquired diarrhoea, several risk factors for the development of Clostridium difficile-associated disease were identified.</description><identifier>ISSN: 1517-8382</identifier><identifier>ISSN: 1678-4405</identifier><identifier>EISSN: 1678-4405</identifier><identifier>DOI: 10.1016/j.bjm.2016.07.011</identifier><identifier>PMID: 27528082</identifier><language>eng</language><publisher>Brazil: Elsevier Editora Ltda</publisher><subject>Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Case-Control Studies ; Clostridioides difficile - isolation & purification ; Clostridioides difficile - metabolism ; Clostridium difficile ; Clostridium Infections - diagnosis ; Clostridium Infections - drug therapy ; Clostridium Infections - epidemiology ; Clostridium Infections - microbiology ; Cross Infection ; Hospital-acquired diarrhoea ; Hospitalization ; Humans ; Medical Microbiology ; MICROBIOLOGY ; Odds Ratio ; Risk Factors ; Serbia ; Serbia - epidemiology</subject><ispartof>Brazilian journal of microbiology, 2016-10, Vol.47 (4), p.902-910</ispartof><rights>2016 Sociedade Brasileira de Microbiologia</rights><rights>Copyright © 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.</rights><rights>2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. 2016 Sociedade Brasileira de Microbiologia</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-8eedb5bb1aca886af242836e536ab4d7bfcc86382c940d570a133b6b5d9e36303</citedby><cites>FETCH-LOGICAL-c490t-8eedb5bb1aca886af242836e536ab4d7bfcc86382c940d570a133b6b5d9e36303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052357/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052357/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27528082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Predrag, Stojanović</creatorcontrib><title>Analysis of risk factors and clinical manifestations associated with Clostridium difficile disease in Serbian hospitalized patients</title><title>Brazilian journal of microbiology</title><addtitle>Braz J Microbiol</addtitle><description>Clostridium difficile is the leading cause of infectious diarrhoea in hospitalized patients. The aim of this study was to determine the risk factors important for the development of hospital-acquired Clostridium difficile-associated disease and clinical manifestations of Clostridium difficile-associated disease. The clinical trial group included 37 hospitalized patients who were selected according to the inclusion criteria. A control group of 74 hospitalized patients was individually matched with cases based on hospital, age (within 4 years), sex and month of admission.
Clostridium difficile-associated disease most commonly manifested as diarrhoea (56.76%) and colitis (32%), while in 8.11% of patients, it was diagnosed as pseudomembranous colitis, and in one patient, it was diagnosed as fulminant colitis. Statistically significant associations (p<0.05) were found with the presence of chronic renal failure, chronic obstructive pulmonary disease, cerebrovascular accident (stroke) and haemodialysis. In this study, it was confirmed that all the groups of antibiotics, except for tetracycline and trimethoprim–sulfamethoxazole, were statistically significant risk factors for Clostridium difficile-associated disease (p<0.05). However, it was difficult to determine the individual role of antibiotics in the development of Clostridium difficile-associated disease. Univariate logistic regression also found that applying antibiotic therapy, the duration of antibiotic therapy, administration of two or more antibiotics to treat infections, administering laxatives and the total number of days spent in the hospital significantly affected the onset of Clostridium difficile-associated disease (p<0.05), and associations were confirmed using the multivariate model for the application of antibiotic therapy (p=0.001), duration of antibiotic treatment (p=0.01), use of laxatives (p=0.01) and total number of days spent in the hospital (p=0.001). In this study of patients with hospital-acquired diarrhoea, several risk factors for the development of Clostridium difficile-associated disease were identified.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Case-Control Studies</subject><subject>Clostridioides difficile - isolation & purification</subject><subject>Clostridioides difficile - metabolism</subject><subject>Clostridium difficile</subject><subject>Clostridium Infections - diagnosis</subject><subject>Clostridium Infections - drug therapy</subject><subject>Clostridium Infections - epidemiology</subject><subject>Clostridium Infections - microbiology</subject><subject>Cross Infection</subject><subject>Hospital-acquired diarrhoea</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Medical Microbiology</subject><subject>MICROBIOLOGY</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Serbia</subject><subject>Serbia - epidemiology</subject><issn>1517-8382</issn><issn>1678-4405</issn><issn>1678-4405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAUjBCIlsIP4IJ85JLw7MSJV0hI1YovqRKHwtly7Bf2LY692NmicuWP42hLBRdOftKbGc-bqarnHBoOvH-1b8b93IgyNjA0wPmD6pz3g6q7DuTDMks-1KpV4qx6kvMeQEjoxOPqTAxSKFDivPp1GYy_zZRZnFii_I1Nxi4xZWaCY9ZTIGs8m02gCfNiFoqh7HKOlsyCjv2gZce2PuYlkaPjzBxNE1nyWKaMJiOjwK4xjWQC28V8oMV4-lmoh6KGYclPq0eT8Rmf3b0X1Zd3bz9vP9RXn95_3F5e1bbbwFIrRDfKceTGGqV6M4lOqLZH2fZm7NwwTtaqvlxrNx04OYDhbTv2o3QbbPsW2ouqOelmS-ij3sdjKtdnfb0Gpdeg1iwBoAPYgCiENyfC4TjO6Gwxm4zXh0SzSbc6GtL_bgLt9Nd4oyVI0cqhCLy8E0jx-7Hkp2fKFr03AeMxa67a4n7tokD5CWpTzDnhdP8NB722rfe6tK1XhxoGXdounBd_-7tn_Km3AF6fAFhivSFMej09WHSU0C7aRfqP_G-bSby1</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Predrag, Stojanović</creator><general>Elsevier Editora Ltda</general><general>Elsevier</general><general>Sociedade Brasileira de Microbiologia</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope></search><sort><creationdate>20161001</creationdate><title>Analysis of risk factors and clinical manifestations associated with Clostridium difficile disease in Serbian hospitalized patients</title><author>Predrag, Stojanović</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-8eedb5bb1aca886af242836e536ab4d7bfcc86382c940d570a133b6b5d9e36303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Case-Control Studies</topic><topic>Clostridioides difficile - isolation & purification</topic><topic>Clostridioides difficile - metabolism</topic><topic>Clostridium difficile</topic><topic>Clostridium Infections - diagnosis</topic><topic>Clostridium Infections - drug therapy</topic><topic>Clostridium Infections - epidemiology</topic><topic>Clostridium Infections - microbiology</topic><topic>Cross Infection</topic><topic>Hospital-acquired diarrhoea</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Medical Microbiology</topic><topic>MICROBIOLOGY</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Serbia</topic><topic>Serbia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Predrag, Stojanović</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><jtitle>Brazilian journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Predrag, Stojanović</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of risk factors and clinical manifestations associated with Clostridium difficile disease in Serbian hospitalized patients</atitle><jtitle>Brazilian journal of microbiology</jtitle><addtitle>Braz J Microbiol</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>47</volume><issue>4</issue><spage>902</spage><epage>910</epage><pages>902-910</pages><issn>1517-8382</issn><issn>1678-4405</issn><eissn>1678-4405</eissn><abstract>Clostridium difficile is the leading cause of infectious diarrhoea in hospitalized patients. The aim of this study was to determine the risk factors important for the development of hospital-acquired Clostridium difficile-associated disease and clinical manifestations of Clostridium difficile-associated disease. The clinical trial group included 37 hospitalized patients who were selected according to the inclusion criteria. A control group of 74 hospitalized patients was individually matched with cases based on hospital, age (within 4 years), sex and month of admission.
Clostridium difficile-associated disease most commonly manifested as diarrhoea (56.76%) and colitis (32%), while in 8.11% of patients, it was diagnosed as pseudomembranous colitis, and in one patient, it was diagnosed as fulminant colitis. Statistically significant associations (p<0.05) were found with the presence of chronic renal failure, chronic obstructive pulmonary disease, cerebrovascular accident (stroke) and haemodialysis. In this study, it was confirmed that all the groups of antibiotics, except for tetracycline and trimethoprim–sulfamethoxazole, were statistically significant risk factors for Clostridium difficile-associated disease (p<0.05). However, it was difficult to determine the individual role of antibiotics in the development of Clostridium difficile-associated disease. Univariate logistic regression also found that applying antibiotic therapy, the duration of antibiotic therapy, administration of two or more antibiotics to treat infections, administering laxatives and the total number of days spent in the hospital significantly affected the onset of Clostridium difficile-associated disease (p<0.05), and associations were confirmed using the multivariate model for the application of antibiotic therapy (p=0.001), duration of antibiotic treatment (p=0.01), use of laxatives (p=0.01) and total number of days spent in the hospital (p=0.001). In this study of patients with hospital-acquired diarrhoea, several risk factors for the development of Clostridium difficile-associated disease were identified.</abstract><cop>Brazil</cop><pub>Elsevier Editora Ltda</pub><pmid>27528082</pmid><doi>10.1016/j.bjm.2016.07.011</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Case-Control Studies Clostridioides difficile - isolation & purification Clostridioides difficile - metabolism Clostridium difficile Clostridium Infections - diagnosis Clostridium Infections - drug therapy Clostridium Infections - epidemiology Clostridium Infections - microbiology Cross Infection Hospital-acquired diarrhoea Hospitalization Humans Medical Microbiology MICROBIOLOGY Odds Ratio Risk Factors Serbia Serbia - epidemiology |
| title | Analysis of risk factors and clinical manifestations associated with Clostridium difficile disease in Serbian hospitalized patients |
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