Applications of recombinant Pichia pastoris in the healthcare industry
Since the 1970s, the establishment and development of the biotech industry has improved exponentially, allowing the commercial production of biopharmaceutical proteins. Nowadays, new recombinant protein production is considered a multibillion-dollar market, in which about 25% of commercial pharmaceu...
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| Veröffentlicht in: | Brazilian journal of microbiology 2013-12, Vol.44 (4), p.1043-1048 |
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| container_title | Brazilian journal of microbiology |
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| creator | Weinacker, Daniel Rabert, Claudia Zepeda, Andrea B Figueroa, Carolina A Pessoa, Adalberto Farías, Jorge G |
| description | Since the 1970s, the establishment and development of the biotech industry has improved exponentially, allowing the commercial production of biopharmaceutical proteins. Nowadays, new recombinant protein production is considered a multibillion-dollar market, in which about 25% of commercial pharmaceuticals are biopharmaceuticals. But to achieve a competitive production process is not an easy task. Any production process has to be highly productive, efficient and economic. Despite that the perfect host is still not discovered, several research groups have chosen Pichia pastoris as expression system for the production of their protein because of its many features. The attempt of this review is to embrace several research lines that have adopted Pichia pastoris as their expression system to produce a protein on an industrial scale in the health care industry. |
| doi_str_mv | 10.1590/S1517-83822013000400004 |
| format | Article |
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| subjects | Biosynthesis Biotechnology - methods Health Care Sector Humans Industrial Microbiology - methods MICROBIOLOGY Organisms, Genetically Modified Pharmaceutical sciences Pichia - genetics Pichia - metabolism Proteins Review Technology, Pharmaceutical - methods Yeast |
| title | Applications of recombinant Pichia pastoris in the healthcare industry |
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