Effect of extracts and isolated compounds from Chresta scapigera on viability of Leishmania amazonensis and Trypanosoma cruzi

Effect of extracts and isolated compounds from Chresta scapigera on viability of Leishmania amazonensis and Trypanosoma cruzi

Fractionation of bioactive crude extracts of Chresta scapigera led to the isolation of four triterpenes and five flavonoids, among them beta-amyrin acetate (1), 11alpha,12alpha-oxidetaraxeryl acetate (2) and lupeol (3), as well as the flavonoids apigenin (6), kaempferol (7), crysoeriol (8) and luteo...

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Veröffentlicht in:Revista brasileira de ciências farmacêuticas 2007-06, Vol.43 (2), p.295-300
Hauptverfasser: Schinor, Elisandra Cristina, Salvador, Marcos José, Pral, Elisabeth Mieko Furusho, Alfieri, Silvia Celina, Albuquerque, Sérgio, Dias, Diones Aparecida
Format: Artikel
Sprache:eng
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PHARMACOLOGY & PHARMACY
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Zusammenfassung:Fractionation of bioactive crude extracts of Chresta scapigera led to the isolation of four triterpenes and five flavonoids, among them beta-amyrin acetate (1), 11alpha,12alpha-oxidetaraxeryl acetate (2) and lupeol (3), as well as the flavonoids apigenin (6), kaempferol (7), crysoeriol (8) and luteolin (9) were active against Leishmania amazonensis amastigotes-like stages, while only the flavonoids (6), (7) and (9) showed toxicity towards bloods trypomastigote forms of Trypanosoma cruzi.
ISSN:1516-9332
1516-9332
DOI:10.1590/S1516-93322007000200016