Effects of pregabalin on behavioral alterations induced by ketamine in rats
The aim of this study is to investigate the effects of pregabalin on the behavior of rats under the influence of ketamine, an NMDA receptor antagonist that mimics the symptoms of schizophrenia. Rats were injected with saline or 25mg/kg ketamine intraperitoneally. After that, behavior modifications w...
Gespeichert in:
| Veröffentlicht in: | Revista brasileira de psiquiatria 2012-10, Vol.34 (3), p.329-333 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 333 |
|---|---|
| container_issue | 3 |
| container_start_page | 329 |
| container_title | Revista brasileira de psiquiatria |
| container_volume | 34 |
| creator | Nunes, Emerson Arcoverde Canever, Leila de Oliveira, Larissa Luca, Renata D’altoe de Quevedo, João Zugno, Alexandra Peregrino, Antonio Crippa, José Alexandre S. Dursun, Serdar M. Baker, Glen B. Hallak, Jaime Eduardo C. |
| description | The aim of this study is to investigate the effects of pregabalin on the behavior of rats under the influence of ketamine, an NMDA receptor antagonist that mimics the symptoms of schizophrenia.
Rats were injected with saline or 25mg/kg ketamine intraperitoneally. After that, behavior modifications were investigated by the evaluation of stereotypy and hyperlocomotion, after treating rats with pregabalin (at doses of 30mg/kg or 100mg/kg) or placebo (saline solution).
The administration of pregabalin reduced ketamine-induced hyperlocomotion. However, neither doses of pregabalin had a significant effect on ketamine-induced stereotypy.
This is the first study to investigate the effects of pregabalin using an animal model of psychosis. Furthermore, our results indicate that behavioral changes induced by ketamine in rats can be reversed with the use of pregabalin, suggesting its potential to treat psychotic symptoms.
O presente estudo tem como objetivo investigar os efeitos da pregabalina sobre as alterações comportamentais em ratos induzidas pela cetamina, um antagonista do receptor glutamatérgico NMDA, utilizado em modelos animais de psicose.
Ratos receberam injeção com solução salina ou cetamina, na dose de 25mg/kg, com posterior avaliação das alterações comportamentais induzidas, através da avaliação da estereotipia e hiperlocomoção, depois destes ratos terem sido tratados com pregabalina (30mg/kg ou 100mg/kg) ou placebo.
A administração de pregabalina reduziu a hiperlocomoção nos ratos sob o efeito da cetamina. No entanto, nenhuma das doses de pregabalina teve efeito significativo sobre a estereotipia induzida pela cetamina.
Este é o primeiro estudo que investiga os efeitos da pregabalina em um modelo animal de psicose. Nossos resultados indicam que alterações comportamentais induzidas pela cetamina em ratos podem ser revertidas após uso da pregabalina, o que sugere um possível potencial desta no tratamento de sintomas psicóticos. |
| doi_str_mv | 10.1016/j.rbp.2012.02.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_sciel</sourceid><recordid>TN_cdi_scielo_journals_S1516_44462012000300013</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S1516_44462012000300013</scielo_id><els_id>S1516444612000116</els_id><sourcerecordid>1312177200</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-56417c84cc4a781c5c4224c9bf99b6c02ffaee778843ff0c1338b7e91b6d5d323</originalsourceid><addsrcrecordid>eNp9kEtP7SAUhYnR-Dj6A-7EMHTSyquljSNjfEUTB2rijADdeDn2lCO0Jv57aY46NNkEAmutzf4Q-kdJSQmtT5dlNOuSEcpKkotUW2ifNqQtRMVetvO5onUhhKj30EFKS0KY5I3cRXuMC9ZK2e6ju0vnwI4JB4fXEV610b0fcBiwgf_6w4eoe6z7EaIefRgS9kM3Weiw-cRvMOqVHyDf4fycDtGO032Co-99gZ6vLp8ubor7h-vbi_P7wvK6GouqFlTaRlgrtGyoraxgTNjWuLY1tSXMOQ0gZdMI7hyxlPPGSGipqbuq44wvULnJTdZDH9QyTHHIDdXjPLCaB56ZEEJ4Xtm-QCcbwzqG9wnSqFY-Weh7PUCYkqKcMipldmQp3UhtDClFcGod_UrHT0WJmqGrpcrQ1dxAkVykyp7j7_jJrKD7dfxQzoKzjQAylQ8PUc0_HzJGHzN81QX_R_wX5rGPPw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1312177200</pqid></control><display><type>article</type><title>Effects of pregabalin on behavioral alterations induced by ketamine in rats</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><creator>Nunes, Emerson Arcoverde ; Canever, Leila ; de Oliveira, Larissa ; Luca, Renata D’altoe de ; Quevedo, João ; Zugno, Alexandra ; Peregrino, Antonio ; Crippa, José Alexandre S. ; Dursun, Serdar M. ; Baker, Glen B. ; Hallak, Jaime Eduardo C.</creator><creatorcontrib>Nunes, Emerson Arcoverde ; Canever, Leila ; de Oliveira, Larissa ; Luca, Renata D’altoe de ; Quevedo, João ; Zugno, Alexandra ; Peregrino, Antonio ; Crippa, José Alexandre S. ; Dursun, Serdar M. ; Baker, Glen B. ; Hallak, Jaime Eduardo C.</creatorcontrib><description>The aim of this study is to investigate the effects of pregabalin on the behavior of rats under the influence of ketamine, an NMDA receptor antagonist that mimics the symptoms of schizophrenia.
Rats were injected with saline or 25mg/kg ketamine intraperitoneally. After that, behavior modifications were investigated by the evaluation of stereotypy and hyperlocomotion, after treating rats with pregabalin (at doses of 30mg/kg or 100mg/kg) or placebo (saline solution).
The administration of pregabalin reduced ketamine-induced hyperlocomotion. However, neither doses of pregabalin had a significant effect on ketamine-induced stereotypy.
This is the first study to investigate the effects of pregabalin using an animal model of psychosis. Furthermore, our results indicate that behavioral changes induced by ketamine in rats can be reversed with the use of pregabalin, suggesting its potential to treat psychotic symptoms.
O presente estudo tem como objetivo investigar os efeitos da pregabalina sobre as alterações comportamentais em ratos induzidas pela cetamina, um antagonista do receptor glutamatérgico NMDA, utilizado em modelos animais de psicose.
Ratos receberam injeção com solução salina ou cetamina, na dose de 25mg/kg, com posterior avaliação das alterações comportamentais induzidas, através da avaliação da estereotipia e hiperlocomoção, depois destes ratos terem sido tratados com pregabalina (30mg/kg ou 100mg/kg) ou placebo.
A administração de pregabalina reduziu a hiperlocomoção nos ratos sob o efeito da cetamina. No entanto, nenhuma das doses de pregabalina teve efeito significativo sobre a estereotipia induzida pela cetamina.
Este é o primeiro estudo que investiga os efeitos da pregabalina em um modelo animal de psicose. Nossos resultados indicam que alterações comportamentais induzidas pela cetamina em ratos podem ser revertidas após uso da pregabalina, o que sugere um possível potencial desta no tratamento de sintomas psicóticos.</description><identifier>ISSN: 1516-4446</identifier><identifier>ISSN: 1809-452X</identifier><identifier>EISSN: 1809-452X</identifier><identifier>DOI: 10.1016/j.rbp.2012.02.005</identifier><identifier>PMID: 23429779</identifier><language>eng</language><publisher>Brazil: Elsevier Editora Ltda</publisher><subject>Animals ; Anticonvulsants ; Anticonvulsivantes ; Antipsychotic Agents - administration & dosage ; Behavior, Animal - drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Esquizofrenia ; Excitatory Amino Acid Antagonists - pharmacology ; gamma-Aminobutyric Acid - administration & dosage ; gamma-Aminobutyric Acid - analogs & derivatives ; Ketamine - pharmacology ; Male ; Other Areas of Neuroscience and Other Aspects of Psychopharmacology ; Outras áreas das neurociências e outros aspectos de psicofarmacologia ; Pregabalin ; Psicose ; PSYCHIATRY ; Psychoses, Substance-Induced - drug therapy ; Psychosis ; Rats ; Rats, Wistar ; Schizophrenia ; Schizophrenia - chemically induced ; Schizophrenia - drug therapy</subject><ispartof>Revista brasileira de psiquiatria, 2012-10, Vol.34 (3), p.329-333</ispartof><rights>2011 Elsevier Editora Ltda.</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-56417c84cc4a781c5c4224c9bf99b6c02ffaee778843ff0c1338b7e91b6d5d323</citedby><cites>FETCH-LOGICAL-c365t-56417c84cc4a781c5c4224c9bf99b6c02ffaee778843ff0c1338b7e91b6d5d323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23429779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nunes, Emerson Arcoverde</creatorcontrib><creatorcontrib>Canever, Leila</creatorcontrib><creatorcontrib>de Oliveira, Larissa</creatorcontrib><creatorcontrib>Luca, Renata D’altoe de</creatorcontrib><creatorcontrib>Quevedo, João</creatorcontrib><creatorcontrib>Zugno, Alexandra</creatorcontrib><creatorcontrib>Peregrino, Antonio</creatorcontrib><creatorcontrib>Crippa, José Alexandre S.</creatorcontrib><creatorcontrib>Dursun, Serdar M.</creatorcontrib><creatorcontrib>Baker, Glen B.</creatorcontrib><creatorcontrib>Hallak, Jaime Eduardo C.</creatorcontrib><title>Effects of pregabalin on behavioral alterations induced by ketamine in rats</title><title>Revista brasileira de psiquiatria</title><addtitle>Braz J Psychiatry</addtitle><description>The aim of this study is to investigate the effects of pregabalin on the behavior of rats under the influence of ketamine, an NMDA receptor antagonist that mimics the symptoms of schizophrenia.
Rats were injected with saline or 25mg/kg ketamine intraperitoneally. After that, behavior modifications were investigated by the evaluation of stereotypy and hyperlocomotion, after treating rats with pregabalin (at doses of 30mg/kg or 100mg/kg) or placebo (saline solution).
The administration of pregabalin reduced ketamine-induced hyperlocomotion. However, neither doses of pregabalin had a significant effect on ketamine-induced stereotypy.
This is the first study to investigate the effects of pregabalin using an animal model of psychosis. Furthermore, our results indicate that behavioral changes induced by ketamine in rats can be reversed with the use of pregabalin, suggesting its potential to treat psychotic symptoms.
O presente estudo tem como objetivo investigar os efeitos da pregabalina sobre as alterações comportamentais em ratos induzidas pela cetamina, um antagonista do receptor glutamatérgico NMDA, utilizado em modelos animais de psicose.
Ratos receberam injeção com solução salina ou cetamina, na dose de 25mg/kg, com posterior avaliação das alterações comportamentais induzidas, através da avaliação da estereotipia e hiperlocomoção, depois destes ratos terem sido tratados com pregabalina (30mg/kg ou 100mg/kg) ou placebo.
A administração de pregabalina reduziu a hiperlocomoção nos ratos sob o efeito da cetamina. No entanto, nenhuma das doses de pregabalina teve efeito significativo sobre a estereotipia induzida pela cetamina.
Este é o primeiro estudo que investiga os efeitos da pregabalina em um modelo animal de psicose. Nossos resultados indicam que alterações comportamentais induzidas pela cetamina em ratos podem ser revertidas após uso da pregabalina, o que sugere um possível potencial desta no tratamento de sintomas psicóticos.</description><subject>Animals</subject><subject>Anticonvulsants</subject><subject>Anticonvulsivantes</subject><subject>Antipsychotic Agents - administration & dosage</subject><subject>Behavior, Animal - drug effects</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Esquizofrenia</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>gamma-Aminobutyric Acid - administration & dosage</subject><subject>gamma-Aminobutyric Acid - analogs & derivatives</subject><subject>Ketamine - pharmacology</subject><subject>Male</subject><subject>Other Areas of Neuroscience and Other Aspects of Psychopharmacology</subject><subject>Outras áreas das neurociências e outros aspectos de psicofarmacologia</subject><subject>Pregabalin</subject><subject>Psicose</subject><subject>PSYCHIATRY</subject><subject>Psychoses, Substance-Induced - drug therapy</subject><subject>Psychosis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Schizophrenia</subject><subject>Schizophrenia - chemically induced</subject><subject>Schizophrenia - drug therapy</subject><issn>1516-4446</issn><issn>1809-452X</issn><issn>1809-452X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP7SAUhYnR-Dj6A-7EMHTSyquljSNjfEUTB2rijADdeDn2lCO0Jv57aY46NNkEAmutzf4Q-kdJSQmtT5dlNOuSEcpKkotUW2ifNqQtRMVetvO5onUhhKj30EFKS0KY5I3cRXuMC9ZK2e6ju0vnwI4JB4fXEV610b0fcBiwgf_6w4eoe6z7EaIefRgS9kM3Weiw-cRvMOqVHyDf4fycDtGO032Co-99gZ6vLp8ubor7h-vbi_P7wvK6GouqFlTaRlgrtGyoraxgTNjWuLY1tSXMOQ0gZdMI7hyxlPPGSGipqbuq44wvULnJTdZDH9QyTHHIDdXjPLCaB56ZEEJ4Xtm-QCcbwzqG9wnSqFY-Weh7PUCYkqKcMipldmQp3UhtDClFcGod_UrHT0WJmqGrpcrQ1dxAkVykyp7j7_jJrKD7dfxQzoKzjQAylQ8PUc0_HzJGHzN81QX_R_wX5rGPPw</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Nunes, Emerson Arcoverde</creator><creator>Canever, Leila</creator><creator>de Oliveira, Larissa</creator><creator>Luca, Renata D’altoe de</creator><creator>Quevedo, João</creator><creator>Zugno, Alexandra</creator><creator>Peregrino, Antonio</creator><creator>Crippa, José Alexandre S.</creator><creator>Dursun, Serdar M.</creator><creator>Baker, Glen B.</creator><creator>Hallak, Jaime Eduardo C.</creator><general>Elsevier Editora Ltda</general><general>Associação Brasileira de Psiquiatria</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20121001</creationdate><title>Effects of pregabalin on behavioral alterations induced by ketamine in rats</title><author>Nunes, Emerson Arcoverde ; Canever, Leila ; de Oliveira, Larissa ; Luca, Renata D’altoe de ; Quevedo, João ; Zugno, Alexandra ; Peregrino, Antonio ; Crippa, José Alexandre S. ; Dursun, Serdar M. ; Baker, Glen B. ; Hallak, Jaime Eduardo C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-56417c84cc4a781c5c4224c9bf99b6c02ffaee778843ff0c1338b7e91b6d5d323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anticonvulsants</topic><topic>Anticonvulsivantes</topic><topic>Antipsychotic Agents - administration & dosage</topic><topic>Behavior, Animal - drug effects</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Esquizofrenia</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>gamma-Aminobutyric Acid - administration & dosage</topic><topic>gamma-Aminobutyric Acid - analogs & derivatives</topic><topic>Ketamine - pharmacology</topic><topic>Male</topic><topic>Other Areas of Neuroscience and Other Aspects of Psychopharmacology</topic><topic>Outras áreas das neurociências e outros aspectos de psicofarmacologia</topic><topic>Pregabalin</topic><topic>Psicose</topic><topic>PSYCHIATRY</topic><topic>Psychoses, Substance-Induced - drug therapy</topic><topic>Psychosis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Schizophrenia</topic><topic>Schizophrenia - chemically induced</topic><topic>Schizophrenia - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nunes, Emerson Arcoverde</creatorcontrib><creatorcontrib>Canever, Leila</creatorcontrib><creatorcontrib>de Oliveira, Larissa</creatorcontrib><creatorcontrib>Luca, Renata D’altoe de</creatorcontrib><creatorcontrib>Quevedo, João</creatorcontrib><creatorcontrib>Zugno, Alexandra</creatorcontrib><creatorcontrib>Peregrino, Antonio</creatorcontrib><creatorcontrib>Crippa, José Alexandre S.</creatorcontrib><creatorcontrib>Dursun, Serdar M.</creatorcontrib><creatorcontrib>Baker, Glen B.</creatorcontrib><creatorcontrib>Hallak, Jaime Eduardo C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Revista brasileira de psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nunes, Emerson Arcoverde</au><au>Canever, Leila</au><au>de Oliveira, Larissa</au><au>Luca, Renata D’altoe de</au><au>Quevedo, João</au><au>Zugno, Alexandra</au><au>Peregrino, Antonio</au><au>Crippa, José Alexandre S.</au><au>Dursun, Serdar M.</au><au>Baker, Glen B.</au><au>Hallak, Jaime Eduardo C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of pregabalin on behavioral alterations induced by ketamine in rats</atitle><jtitle>Revista brasileira de psiquiatria</jtitle><addtitle>Braz J Psychiatry</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>34</volume><issue>3</issue><spage>329</spage><epage>333</epage><pages>329-333</pages><issn>1516-4446</issn><issn>1809-452X</issn><eissn>1809-452X</eissn><abstract>The aim of this study is to investigate the effects of pregabalin on the behavior of rats under the influence of ketamine, an NMDA receptor antagonist that mimics the symptoms of schizophrenia.
Rats were injected with saline or 25mg/kg ketamine intraperitoneally. After that, behavior modifications were investigated by the evaluation of stereotypy and hyperlocomotion, after treating rats with pregabalin (at doses of 30mg/kg or 100mg/kg) or placebo (saline solution).
The administration of pregabalin reduced ketamine-induced hyperlocomotion. However, neither doses of pregabalin had a significant effect on ketamine-induced stereotypy.
This is the first study to investigate the effects of pregabalin using an animal model of psychosis. Furthermore, our results indicate that behavioral changes induced by ketamine in rats can be reversed with the use of pregabalin, suggesting its potential to treat psychotic symptoms.
O presente estudo tem como objetivo investigar os efeitos da pregabalina sobre as alterações comportamentais em ratos induzidas pela cetamina, um antagonista do receptor glutamatérgico NMDA, utilizado em modelos animais de psicose.
Ratos receberam injeção com solução salina ou cetamina, na dose de 25mg/kg, com posterior avaliação das alterações comportamentais induzidas, através da avaliação da estereotipia e hiperlocomoção, depois destes ratos terem sido tratados com pregabalina (30mg/kg ou 100mg/kg) ou placebo.
A administração de pregabalina reduziu a hiperlocomoção nos ratos sob o efeito da cetamina. No entanto, nenhuma das doses de pregabalina teve efeito significativo sobre a estereotipia induzida pela cetamina.
Este é o primeiro estudo que investiga os efeitos da pregabalina em um modelo animal de psicose. Nossos resultados indicam que alterações comportamentais induzidas pela cetamina em ratos podem ser revertidas após uso da pregabalina, o que sugere um possível potencial desta no tratamento de sintomas psicóticos.</abstract><cop>Brazil</cop><pub>Elsevier Editora Ltda</pub><pmid>23429779</pmid><doi>10.1016/j.rbp.2012.02.005</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1516-4446 |
| ispartof | Revista brasileira de psiquiatria, 2012-10, Vol.34 (3), p.329-333 |
| issn | 1516-4446 1809-452X 1809-452X |
| language | eng |
| recordid | cdi_scielo_journals_S1516_44462012000300013 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
| subjects | Animals Anticonvulsants Anticonvulsivantes Antipsychotic Agents - administration & dosage Behavior, Animal - drug effects Disease Models, Animal Dose-Response Relationship, Drug Esquizofrenia Excitatory Amino Acid Antagonists - pharmacology gamma-Aminobutyric Acid - administration & dosage gamma-Aminobutyric Acid - analogs & derivatives Ketamine - pharmacology Male Other Areas of Neuroscience and Other Aspects of Psychopharmacology Outras áreas das neurociências e outros aspectos de psicofarmacologia Pregabalin Psicose PSYCHIATRY Psychoses, Substance-Induced - drug therapy Psychosis Rats Rats, Wistar Schizophrenia Schizophrenia - chemically induced Schizophrenia - drug therapy |
| title | Effects of pregabalin on behavioral alterations induced by ketamine in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T02%3A28%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_sciel&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20pregabalin%20on%20behavioral%20alterations%20induced%20by%20ketamine%20in%20rats&rft.jtitle=Revista%20brasileira%20de%20psiquiatria&rft.au=Nunes,%20Emerson%20Arcoverde&rft.date=2012-10-01&rft.volume=34&rft.issue=3&rft.spage=329&rft.epage=333&rft.pages=329-333&rft.issn=1516-4446&rft.eissn=1809-452X&rft_id=info:doi/10.1016/j.rbp.2012.02.005&rft_dat=%3Cproquest_sciel%3E1312177200%3C/proquest_sciel%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1312177200&rft_id=info:pmid/23429779&rft_scielo_id=S1516_44462012000300013&rft_els_id=S1516444612000116&rfr_iscdi=true |