Polypharmacy and suicide attempts in bipolar disorder
The aim of this study was to assess the association between suicide attempts and the use of multiple drugs in patients with bipolar disorder. One hundred sixty-nine bipolar disorder outpatients diagnosed using the DSM-IV Structured Clinical Interview were included. Demographic and socioeconomic data...
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| Veröffentlicht in: | Revista brasileira de psiquiatria 2007-03, Vol.29 (1), p.35-38 |
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| creator | Gazalle, Fernando Kratz Hallal, Pedro Curi Tramontina, Juliana Rosa, Adriane Ribeiro Andreazza, Ana Cristina Zanatto, Vanessa Santin, Aida Kapczinski, Flávio Ceresér, Keila Maria |
| description | The aim of this study was to assess the association between suicide attempts and the use of multiple drugs in patients with bipolar disorder.
One hundred sixty-nine bipolar disorder outpatients diagnosed using the DSM-IV Structured Clinical Interview were included. Demographic and socioeconomic data, number of medications currently in use, history of suicide attempts, number of years undiagnosed, age of onset and current psychiatric co-morbidities were assessed using a structured questionnaire and DSM-IV criteria. The main outcome measure was the number of psychotropic drugs currently in use.
Approximately half of all patients (48.5%) presented a history of suicide attempt; 84% were using more than one medication, and 19% were using more than three drugs. The most frequent combinations of drugs used by these patients were: lithium + valproate (17%); lithium + antipsychotics (10%); lithium + valproate + antipsychotics (9%); and antidepressants + any drug (6%). The number of suicide attempts was associated with the use of multiple drugs.
Our findings support the notion that the use of combination therapy in bipolar disorder may be related to severity of the BD, such as number of suicide attempts. |
| doi_str_mv | 10.1590/S1516-44462006005000021 |
| format | Article |
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One hundred sixty-nine bipolar disorder outpatients diagnosed using the DSM-IV Structured Clinical Interview were included. Demographic and socioeconomic data, number of medications currently in use, history of suicide attempts, number of years undiagnosed, age of onset and current psychiatric co-morbidities were assessed using a structured questionnaire and DSM-IV criteria. The main outcome measure was the number of psychotropic drugs currently in use.
Approximately half of all patients (48.5%) presented a history of suicide attempt; 84% were using more than one medication, and 19% were using more than three drugs. The most frequent combinations of drugs used by these patients were: lithium + valproate (17%); lithium + antipsychotics (10%); lithium + valproate + antipsychotics (9%); and antidepressants + any drug (6%). The number of suicide attempts was associated with the use of multiple drugs.
Our findings support the notion that the use of combination therapy in bipolar disorder may be related to severity of the BD, such as number of suicide attempts.</description><identifier>ISSN: 1516-4446</identifier><identifier>ISSN: 1809-452X</identifier><identifier>EISSN: 1809-452X</identifier><identifier>DOI: 10.1590/S1516-44462006005000021</identifier><identifier>PMID: 17435926</identifier><language>eng</language><publisher>Brazil: Associação Brasileira de Psiquiatria</publisher><subject>Adolescent ; Adult ; Age of Onset ; Antidepressive Agents - therapeutic use ; Antimanic Agents - therapeutic use ; Antipsychotic Agents - therapeutic use ; Bipolar Disorder - drug therapy ; Bipolar Disorder - epidemiology ; Brazil - epidemiology ; Comorbidity ; Drug Therapy, Combination ; Epidemiologic Methods ; Female ; Humans ; Interview, Psychological ; Lithium Compounds - therapeutic use ; Male ; Polypharmacy ; PSYCHIATRY ; Suicide, Attempted - statistics & numerical data ; Valproic Acid - therapeutic use</subject><ispartof>Revista brasileira de psiquiatria, 2007-03, Vol.29 (1), p.35-38</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-ac5fc8b1e2fc67d9b91a79fd9b7d6858144c98415adf0757696fc69946b72ce93</citedby><cites>FETCH-LOGICAL-c399t-ac5fc8b1e2fc67d9b91a79fd9b7d6858144c98415adf0757696fc69946b72ce93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17435926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gazalle, Fernando Kratz</creatorcontrib><creatorcontrib>Hallal, Pedro Curi</creatorcontrib><creatorcontrib>Tramontina, Juliana</creatorcontrib><creatorcontrib>Rosa, Adriane Ribeiro</creatorcontrib><creatorcontrib>Andreazza, Ana Cristina</creatorcontrib><creatorcontrib>Zanatto, Vanessa</creatorcontrib><creatorcontrib>Santin, Aida</creatorcontrib><creatorcontrib>Kapczinski, Flávio</creatorcontrib><creatorcontrib>Ceresér, Keila Maria</creatorcontrib><title>Polypharmacy and suicide attempts in bipolar disorder</title><title>Revista brasileira de psiquiatria</title><addtitle>Braz J Psychiatry</addtitle><description>The aim of this study was to assess the association between suicide attempts and the use of multiple drugs in patients with bipolar disorder.
One hundred sixty-nine bipolar disorder outpatients diagnosed using the DSM-IV Structured Clinical Interview were included. Demographic and socioeconomic data, number of medications currently in use, history of suicide attempts, number of years undiagnosed, age of onset and current psychiatric co-morbidities were assessed using a structured questionnaire and DSM-IV criteria. The main outcome measure was the number of psychotropic drugs currently in use.
Approximately half of all patients (48.5%) presented a history of suicide attempt; 84% were using more than one medication, and 19% were using more than three drugs. The most frequent combinations of drugs used by these patients were: lithium + valproate (17%); lithium + antipsychotics (10%); lithium + valproate + antipsychotics (9%); and antidepressants + any drug (6%). The number of suicide attempts was associated with the use of multiple drugs.
Our findings support the notion that the use of combination therapy in bipolar disorder may be related to severity of the BD, such as number of suicide attempts.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Antimanic Agents - therapeutic use</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Brazil - epidemiology</subject><subject>Comorbidity</subject><subject>Drug Therapy, Combination</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Interview, Psychological</subject><subject>Lithium Compounds - therapeutic use</subject><subject>Male</subject><subject>Polypharmacy</subject><subject>PSYCHIATRY</subject><subject>Suicide, Attempted - statistics & numerical data</subject><subject>Valproic Acid - therapeutic use</subject><issn>1516-4446</issn><issn>1809-452X</issn><issn>1809-452X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF9LwzAUxYMobk6_gvbJt84kzZ_mUYZTYaCggm8hTVLMaJuatA_79mauMgxcch9-5x7OAeAGwSWiAt69IYpYTghhGEIGIYXpYXQC5qiEIicUf56m_Q-agYsYt4ngRcnPwQxxUlCB2RzQV9_s-i8VWqV3mepMFkennbGZGgbb9kPMXJdVrveNCplx0QdjwyU4q1UT7dX0L8DH-uF99ZRvXh6fV_ebXBdCDLnStNZlhSyuNeNGVAIpLuq0cMNKWiJCtCgJosrUkFPOBEugEIRVHGsrigVYHu5G7Wzj5daPoUuG8je_nPLzlB3tByXB7UHQB_892jjI1kVtm0Z11o9RcliUBHOWQH4AdfAxBlvLPrhWhZ1EUO4r_m9xrDgpryeLsWqtOeqmTosfXGhz0A</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Gazalle, Fernando Kratz</creator><creator>Hallal, Pedro Curi</creator><creator>Tramontina, Juliana</creator><creator>Rosa, Adriane Ribeiro</creator><creator>Andreazza, Ana Cristina</creator><creator>Zanatto, Vanessa</creator><creator>Santin, Aida</creator><creator>Kapczinski, Flávio</creator><creator>Ceresér, Keila Maria</creator><general>Associação Brasileira de Psiquiatria</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20070301</creationdate><title>Polypharmacy and suicide attempts in bipolar disorder</title><author>Gazalle, Fernando Kratz ; Hallal, Pedro Curi ; Tramontina, Juliana ; Rosa, Adriane Ribeiro ; Andreazza, Ana Cristina ; Zanatto, Vanessa ; Santin, Aida ; Kapczinski, Flávio ; Ceresér, Keila Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-ac5fc8b1e2fc67d9b91a79fd9b7d6858144c98415adf0757696fc69946b72ce93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Antimanic Agents - therapeutic use</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Brazil - epidemiology</topic><topic>Comorbidity</topic><topic>Drug Therapy, Combination</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Humans</topic><topic>Interview, Psychological</topic><topic>Lithium Compounds - therapeutic use</topic><topic>Male</topic><topic>Polypharmacy</topic><topic>PSYCHIATRY</topic><topic>Suicide, Attempted - statistics & numerical data</topic><topic>Valproic Acid - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gazalle, Fernando Kratz</creatorcontrib><creatorcontrib>Hallal, Pedro Curi</creatorcontrib><creatorcontrib>Tramontina, Juliana</creatorcontrib><creatorcontrib>Rosa, Adriane Ribeiro</creatorcontrib><creatorcontrib>Andreazza, Ana Cristina</creatorcontrib><creatorcontrib>Zanatto, Vanessa</creatorcontrib><creatorcontrib>Santin, Aida</creatorcontrib><creatorcontrib>Kapczinski, Flávio</creatorcontrib><creatorcontrib>Ceresér, Keila Maria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Revista brasileira de psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gazalle, Fernando Kratz</au><au>Hallal, Pedro Curi</au><au>Tramontina, Juliana</au><au>Rosa, Adriane Ribeiro</au><au>Andreazza, Ana Cristina</au><au>Zanatto, Vanessa</au><au>Santin, Aida</au><au>Kapczinski, Flávio</au><au>Ceresér, Keila Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polypharmacy and suicide attempts in bipolar disorder</atitle><jtitle>Revista brasileira de psiquiatria</jtitle><addtitle>Braz J Psychiatry</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>29</volume><issue>1</issue><spage>35</spage><epage>38</epage><pages>35-38</pages><issn>1516-4446</issn><issn>1809-452X</issn><eissn>1809-452X</eissn><abstract>The aim of this study was to assess the association between suicide attempts and the use of multiple drugs in patients with bipolar disorder.
One hundred sixty-nine bipolar disorder outpatients diagnosed using the DSM-IV Structured Clinical Interview were included. Demographic and socioeconomic data, number of medications currently in use, history of suicide attempts, number of years undiagnosed, age of onset and current psychiatric co-morbidities were assessed using a structured questionnaire and DSM-IV criteria. The main outcome measure was the number of psychotropic drugs currently in use.
Approximately half of all patients (48.5%) presented a history of suicide attempt; 84% were using more than one medication, and 19% were using more than three drugs. The most frequent combinations of drugs used by these patients were: lithium + valproate (17%); lithium + antipsychotics (10%); lithium + valproate + antipsychotics (9%); and antidepressants + any drug (6%). The number of suicide attempts was associated with the use of multiple drugs.
Our findings support the notion that the use of combination therapy in bipolar disorder may be related to severity of the BD, such as number of suicide attempts.</abstract><cop>Brazil</cop><pub>Associação Brasileira de Psiquiatria</pub><pmid>17435926</pmid><doi>10.1590/S1516-44462006005000021</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals |
| subjects | Adolescent Adult Age of Onset Antidepressive Agents - therapeutic use Antimanic Agents - therapeutic use Antipsychotic Agents - therapeutic use Bipolar Disorder - drug therapy Bipolar Disorder - epidemiology Brazil - epidemiology Comorbidity Drug Therapy, Combination Epidemiologic Methods Female Humans Interview, Psychological Lithium Compounds - therapeutic use Male Polypharmacy PSYCHIATRY Suicide, Attempted - statistics & numerical data Valproic Acid - therapeutic use |
| title | Polypharmacy and suicide attempts in bipolar disorder |
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