HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study
Increasing genetic diversity of HIV-1 and emergence of drug-resistant mutations may reduce the efficacy of antiretroviral therapy and prophylaxis that are used to prevent mother-to-child transmission. The aim of this study was to assess the genetic diversity and prevalence of drug-resistant mutation...
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| Veröffentlicht in: | São Paulo medical journal 2018-03, Vol.136 (2), p.129-135 |
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| creator | Pimenta, Ana Teresa Mancini Correa, Isadora Alonso Melli, Patricia Pereira Dos Santos Abduch, Renata Duarte, Geraldo Couto-Fernandez, José Carlos Quintana, Silvana Maria |
| description | Increasing genetic diversity of HIV-1 and emergence of drug-resistant mutations may reduce the efficacy of antiretroviral therapy and prophylaxis that are used to prevent mother-to-child transmission. The aim of this study was to assess the genetic diversity and prevalence of drug-resistant mutations among HIV-infected pregnant women.
Cross-sectional study at an outpatient clinic for infectious diseases within gynecology and obstetrics.
This study evaluated the dynamics of HIV-1 subtypes and the prevalence of transmitted and acquired drug-resistant mutations among 38 HIV-infected pregnant women (20 previously exposed to antiretroviral therapy and 18 naive), in Ribeirão Preto (SP), Brazil, between 2010 and 2011. Genotyping was performed by means of molecular sequencing of the protease and reverse transcriptase regions of the HIV-1 pol gene.
Subtype B was identified in 84.2% of the samples, recombinant forms between B and F in 7.9%, subtype F1 in 5.3% and the recombinant form K/F in 2.6%. No mutation associated with transmitted drug resistance was detected in the samples from the naive pregnant women, whereas mutations associated with acquired drug resistance were found in 35.0% of the pregnant women previously exposed to antiretroviral therapy.
The results showed that subtype B predominated, while there was low prevalence of sequences with transmitted drug resistance. |
| doi_str_mv | 10.1590/1516-3180.2017.0233011017 |
| format | Article |
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Cross-sectional study at an outpatient clinic for infectious diseases within gynecology and obstetrics.
This study evaluated the dynamics of HIV-1 subtypes and the prevalence of transmitted and acquired drug-resistant mutations among 38 HIV-infected pregnant women (20 previously exposed to antiretroviral therapy and 18 naive), in Ribeirão Preto (SP), Brazil, between 2010 and 2011. Genotyping was performed by means of molecular sequencing of the protease and reverse transcriptase regions of the HIV-1 pol gene.
Subtype B was identified in 84.2% of the samples, recombinant forms between B and F in 7.9%, subtype F1 in 5.3% and the recombinant form K/F in 2.6%. No mutation associated with transmitted drug resistance was detected in the samples from the naive pregnant women, whereas mutations associated with acquired drug resistance were found in 35.0% of the pregnant women previously exposed to antiretroviral therapy.
The results showed that subtype B predominated, while there was low prevalence of sequences with transmitted drug resistance.</description><identifier>ISSN: 1516-3180</identifier><identifier>ISSN: 1806-9460</identifier><identifier>EISSN: 1806-9460</identifier><identifier>DOI: 10.1590/1516-3180.2017.0233011017</identifier><identifier>PMID: 29791608</identifier><language>eng</language><publisher>Brazil: Associação Paulista de Medicina - APM</publisher><subject>Anti-HIV Agents - therapeutic use ; Cross-Sectional Studies ; Drug resistance ; Drug Resistance, Viral - genetics ; Female ; Genetic Variation ; Genotype ; HIV Infections - drug therapy ; HIV Infections - virology ; HIV-1 ; HIV-1 - drug effects ; HIV-1 - genetics ; Humans ; MEDICINE, GENERAL & INTERNAL ; Mutation - genetics ; Phylogeny ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Complications, Infectious - virology ; Prevalence ; RNA, Viral - genetics ; Socioeconomic Factors</subject><ispartof>São Paulo medical journal, 2018-03, Vol.136 (2), p.129-135</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-902cd4ac1528f545ea1618f1a3a2959ca75d63ec34044507eff449bb465c331e3</citedby><cites>FETCH-LOGICAL-c3887-902cd4ac1528f545ea1618f1a3a2959ca75d63ec34044507eff449bb465c331e3</cites><orcidid>0000-0003-2847-7102 ; 0000-0001-7091-9774 ; 0000-0002-9311-786X ; 0000-0002-1524-5292 ; 0000-0001-5383-7793 ; 0000-0002-1689-6142 ; 0000-0002-9248-8271</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29791608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pimenta, Ana Teresa Mancini</creatorcontrib><creatorcontrib>Correa, Isadora Alonso</creatorcontrib><creatorcontrib>Melli, Patricia Pereira Dos Santos</creatorcontrib><creatorcontrib>Abduch, Renata</creatorcontrib><creatorcontrib>Duarte, Geraldo</creatorcontrib><creatorcontrib>Couto-Fernandez, José Carlos</creatorcontrib><creatorcontrib>Quintana, Silvana Maria</creatorcontrib><title>HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study</title><title>São Paulo medical journal</title><addtitle>Sao Paulo Med J</addtitle><description>Increasing genetic diversity of HIV-1 and emergence of drug-resistant mutations may reduce the efficacy of antiretroviral therapy and prophylaxis that are used to prevent mother-to-child transmission. The aim of this study was to assess the genetic diversity and prevalence of drug-resistant mutations among HIV-infected pregnant women.
Cross-sectional study at an outpatient clinic for infectious diseases within gynecology and obstetrics.
This study evaluated the dynamics of HIV-1 subtypes and the prevalence of transmitted and acquired drug-resistant mutations among 38 HIV-infected pregnant women (20 previously exposed to antiretroviral therapy and 18 naive), in Ribeirão Preto (SP), Brazil, between 2010 and 2011. Genotyping was performed by means of molecular sequencing of the protease and reverse transcriptase regions of the HIV-1 pol gene.
Subtype B was identified in 84.2% of the samples, recombinant forms between B and F in 7.9%, subtype F1 in 5.3% and the recombinant form K/F in 2.6%. No mutation associated with transmitted drug resistance was detected in the samples from the naive pregnant women, whereas mutations associated with acquired drug resistance were found in 35.0% of the pregnant women previously exposed to antiretroviral therapy.
The results showed that subtype B predominated, while there was low prevalence of sequences with transmitted drug resistance.</description><subject>Anti-HIV Agents - therapeutic use</subject><subject>Cross-Sectional Studies</subject><subject>Drug resistance</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Female</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - virology</subject><subject>HIV-1</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - genetics</subject><subject>Humans</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Mutation - genetics</subject><subject>Phylogeny</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - drug therapy</subject><subject>Pregnancy Complications, Infectious - virology</subject><subject>Prevalence</subject><subject>RNA, Viral - genetics</subject><subject>Socioeconomic Factors</subject><issn>1516-3180</issn><issn>1806-9460</issn><issn>1806-9460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpFUltuFDEQHCEQCYErIPMXJGbxe-xPsiJkpUhEBPi1PHbPyqvZ8WLPBC1HyDU4ChfDwybLl1vlqmq7uqvqDcELIjR-TwSRNSMKLygmzQJTxjAhpXxSnRZU1ppL_LTUj7yT6kXOG4ypkoQ-r06objSRWJ1W91er7zVBaxhgDA75cAcph3GP7OBRghzyaAcHaIwFGUOCMcW7kGyPfJrWGdltHNZol2A9lHv0M25hQGFAX0ILIf35HdFN0UR0fnvz9h26SPZX6BdomWLOdQY3hjgUrzxOfv-yetbZPsOrh_Os-nb58evyqr7-_Gm1_HBdO6ZUU2tMnefWEUFVJ7gASyRRHbHMUi20s43wkoFjHHMucANdx7luWy6FY4wAO6tWB18f7cbsUtjatDfRBvMPiGltbCph9GBo17Sy4Up7X1p2jRKyE7T1vJNKKquL1-LglV2APppNnFL5UDa3c_Zmzr6MSOESPcaEzoLzg2CX4o8J8mi2ITvoeztAnLKhmLOGSM5IoeoD1c1pJeiObyXYzHtgjj3MvAfm_x4U7euHNlO7BX9UPg6e_QXzRqv-</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Pimenta, Ana Teresa Mancini</creator><creator>Correa, Isadora Alonso</creator><creator>Melli, Patricia Pereira Dos Santos</creator><creator>Abduch, Renata</creator><creator>Duarte, Geraldo</creator><creator>Couto-Fernandez, José Carlos</creator><creator>Quintana, Silvana Maria</creator><general>Associação Paulista de Medicina - APM</general><general>Associação Paulista de Medicina</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2847-7102</orcidid><orcidid>https://orcid.org/0000-0001-7091-9774</orcidid><orcidid>https://orcid.org/0000-0002-9311-786X</orcidid><orcidid>https://orcid.org/0000-0002-1524-5292</orcidid><orcidid>https://orcid.org/0000-0001-5383-7793</orcidid><orcidid>https://orcid.org/0000-0002-1689-6142</orcidid><orcidid>https://orcid.org/0000-0002-9248-8271</orcidid></search><sort><creationdate>201803</creationdate><title>HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study</title><author>Pimenta, Ana Teresa Mancini ; Correa, Isadora Alonso ; Melli, Patricia Pereira Dos Santos ; Abduch, Renata ; Duarte, Geraldo ; Couto-Fernandez, José Carlos ; Quintana, Silvana Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-902cd4ac1528f545ea1618f1a3a2959ca75d63ec34044507eff449bb465c331e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-HIV Agents - therapeutic use</topic><topic>Cross-Sectional Studies</topic><topic>Drug resistance</topic><topic>Drug Resistance, Viral - genetics</topic><topic>Female</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - virology</topic><topic>HIV-1</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - genetics</topic><topic>Humans</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Mutation - genetics</topic><topic>Phylogeny</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - drug therapy</topic><topic>Pregnancy Complications, Infectious - virology</topic><topic>Prevalence</topic><topic>RNA, Viral - genetics</topic><topic>Socioeconomic Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pimenta, Ana Teresa Mancini</creatorcontrib><creatorcontrib>Correa, Isadora Alonso</creatorcontrib><creatorcontrib>Melli, Patricia Pereira Dos Santos</creatorcontrib><creatorcontrib>Abduch, Renata</creatorcontrib><creatorcontrib>Duarte, Geraldo</creatorcontrib><creatorcontrib>Couto-Fernandez, José Carlos</creatorcontrib><creatorcontrib>Quintana, Silvana Maria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>São Paulo medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pimenta, Ana Teresa Mancini</au><au>Correa, Isadora Alonso</au><au>Melli, Patricia Pereira Dos Santos</au><au>Abduch, Renata</au><au>Duarte, Geraldo</au><au>Couto-Fernandez, José Carlos</au><au>Quintana, Silvana Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study</atitle><jtitle>São Paulo medical journal</jtitle><addtitle>Sao Paulo Med J</addtitle><date>2018-03</date><risdate>2018</risdate><volume>136</volume><issue>2</issue><spage>129</spage><epage>135</epage><pages>129-135</pages><issn>1516-3180</issn><issn>1806-9460</issn><eissn>1806-9460</eissn><abstract>Increasing genetic diversity of HIV-1 and emergence of drug-resistant mutations may reduce the efficacy of antiretroviral therapy and prophylaxis that are used to prevent mother-to-child transmission. The aim of this study was to assess the genetic diversity and prevalence of drug-resistant mutations among HIV-infected pregnant women.
Cross-sectional study at an outpatient clinic for infectious diseases within gynecology and obstetrics.
This study evaluated the dynamics of HIV-1 subtypes and the prevalence of transmitted and acquired drug-resistant mutations among 38 HIV-infected pregnant women (20 previously exposed to antiretroviral therapy and 18 naive), in Ribeirão Preto (SP), Brazil, between 2010 and 2011. Genotyping was performed by means of molecular sequencing of the protease and reverse transcriptase regions of the HIV-1 pol gene.
Subtype B was identified in 84.2% of the samples, recombinant forms between B and F in 7.9%, subtype F1 in 5.3% and the recombinant form K/F in 2.6%. No mutation associated with transmitted drug resistance was detected in the samples from the naive pregnant women, whereas mutations associated with acquired drug resistance were found in 35.0% of the pregnant women previously exposed to antiretroviral therapy.
The results showed that subtype B predominated, while there was low prevalence of sequences with transmitted drug resistance.</abstract><cop>Brazil</cop><pub>Associação Paulista de Medicina - APM</pub><pmid>29791608</pmid><doi>10.1590/1516-3180.2017.0233011017</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2847-7102</orcidid><orcidid>https://orcid.org/0000-0001-7091-9774</orcidid><orcidid>https://orcid.org/0000-0002-9311-786X</orcidid><orcidid>https://orcid.org/0000-0002-1524-5292</orcidid><orcidid>https://orcid.org/0000-0001-5383-7793</orcidid><orcidid>https://orcid.org/0000-0002-1689-6142</orcidid><orcidid>https://orcid.org/0000-0002-9248-8271</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anti-HIV Agents - therapeutic use Cross-Sectional Studies Drug resistance Drug Resistance, Viral - genetics Female Genetic Variation Genotype HIV Infections - drug therapy HIV Infections - virology HIV-1 HIV-1 - drug effects HIV-1 - genetics Humans MEDICINE, GENERAL & INTERNAL Mutation - genetics Phylogeny Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - virology Prevalence RNA, Viral - genetics Socioeconomic Factors |
| title | HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study |
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