Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis
This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioass...
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| Veröffentlicht in: | The Brazilian journal of infectious diseases 2008-06, Vol.12 (3), p.226-233 |
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| creator | Andrade Júnior, Dahir Ramos de Santos, Sânia Alves dos Castro, Isac de Andrade, Dahir Ramos de |
| description | This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 +/- 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 +/- 1495.29 pg/mL) (p |
| doi_str_mv | 10.1590/s1413-86702008000300013 |
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We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 +/- 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 +/- 1495.29 pg/mL) (p<0.05). Patients that lost weight had higher TNF alpha levels (15468.54 +/- 4580.54 pg/mL) than those that didn't loose weight (2904.98 +/- 1367.89) (p<0.05). The levels of TNF alpha were higher in patients with a positive PPD skin test than in those with a negative PPD test (p<0.05). There was a positive correlation between patients' clinical severity and the serum levels of TNF alpha. In patients with successive measurements of TNF alpha, we observed that there was a drop in cytokine levels, and also a clinical improvement concomitantly. We concluded that there was a correlation between serum TNF alpha levels and chest X-Ray alterations, loss of weight, positive PPD skin test and clinical severity in patients with tuberculosis. There was evidence of a worse clinical outcome in patients with tuberculosis that presented higher TNF alpha serum levels.</description><identifier>ISSN: 1413-8670</identifier><identifier>ISSN: 1678-4391</identifier><identifier>EISSN: 1678-4391</identifier><identifier>EISSN: 1413-8670</identifier><identifier>DOI: 10.1590/s1413-86702008000300013</identifier><identifier>PMID: 18833408</identifier><language>eng</language><publisher>Brazil: Contexto</publisher><subject>Adult ; Aged ; Biomarkers - blood ; Case-Control Studies ; clinical severity ; cytokines ; Diagnosis ; Female ; Humans ; INFECTIOUS DISEASES ; Male ; Middle Aged ; Mycobacterium ; Physiological aspects ; Severity of Illness Index ; TNF alpha ; Tuberculosis ; Tuberculosis - blood ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - blood ; Young Adult</subject><ispartof>The Brazilian journal of infectious diseases, 2008-06, Vol.12 (3), p.226-233</ispartof><rights>COPYRIGHT 2008 Contexto</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c648t-e54732cb80332742419a1f0393d9a969baa45839027be71b8f651d790fe5e9373</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18833408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrade Júnior, Dahir Ramos de</creatorcontrib><creatorcontrib>Santos, Sânia Alves dos</creatorcontrib><creatorcontrib>Castro, Isac de</creatorcontrib><creatorcontrib>Andrade, Dahir Ramos de</creatorcontrib><title>Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis</title><title>The Brazilian journal of infectious diseases</title><addtitle>Braz J Infect Dis</addtitle><description>This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 +/- 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 +/- 1495.29 pg/mL) (p<0.05). Patients that lost weight had higher TNF alpha levels (15468.54 +/- 4580.54 pg/mL) than those that didn't loose weight (2904.98 +/- 1367.89) (p<0.05). The levels of TNF alpha were higher in patients with a positive PPD skin test than in those with a negative PPD test (p<0.05). There was a positive correlation between patients' clinical severity and the serum levels of TNF alpha. In patients with successive measurements of TNF alpha, we observed that there was a drop in cytokine levels, and also a clinical improvement concomitantly. We concluded that there was a correlation between serum TNF alpha levels and chest X-Ray alterations, loss of weight, positive PPD skin test and clinical severity in patients with tuberculosis. There was evidence of a worse clinical outcome in patients with tuberculosis that presented higher TNF alpha serum levels.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>clinical severity</subject><subject>cytokines</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>INFECTIOUS DISEASES</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycobacterium</subject><subject>Physiological aspects</subject><subject>Severity of Illness Index</subject><subject>TNF alpha</subject><subject>Tuberculosis</subject><subject>Tuberculosis - blood</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Young Adult</subject><issn>1413-8670</issn><issn>1678-4391</issn><issn>1678-4391</issn><issn>1413-8670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqFkl1rFDEUhgdRbK3-BR0Qerf15GPycVkWq4WCF-p1yGTOdLNkJmsy09J_b6a7WhdBCfk6PO_h5M2pqncELkij4UMmnLCVEhIogAIAViZhz6pTIqRacabJ83L-BZ1Ur3LeAtAGOLysTohSjHFQp1W7jilhsJOPY93idI841hnTPNTTPMRUj-hSzD7XvXVTuduw29g64B2GXNuxq13wo3c2FNUdJj891LEv2haTm8OifF296G3I-Oawn1Xfrz5-W39e3Xz5dL2-vFk5wdW0woZLRl2rgDEqOeVEW9ID06zTVgvdWssbxTRQ2aIkrepFQzqpoccGNZPsrLre5-2i3Zpd8oNNDyZabx4DMd0amybvAppOdl0vrNZcAUcitETKpFKtoMgQmpLrYp8rO48hmm2c01iKN18XT81fxhfB-V6wS_HHjHkyg88OQ7AjxjkboUUxX4v_gkQzqstSwPd78NaWiv3YxylZt8DmkhIGjAqingo9osrocPAujtj7Ej8SnP8h2KAN0ybHMC8NkI9BuQeX_88J-9-WEjBLE_7Di7eHJ87tgN2T7tB17CcAG9Gk</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Andrade Júnior, Dahir Ramos de</creator><creator>Santos, Sânia Alves dos</creator><creator>Castro, Isac de</creator><creator>Andrade, Dahir Ramos de</creator><general>Contexto</general><general>Brazilian Society of Infectious Diseases</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>INF</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>200806</creationdate><title>Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis</title><author>Andrade Júnior, Dahir Ramos de ; Santos, Sânia Alves dos ; Castro, Isac de ; Andrade, Dahir Ramos de</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c648t-e54732cb80332742419a1f0393d9a969baa45839027be71b8f651d790fe5e9373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>clinical severity</topic><topic>cytokines</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>INFECTIOUS DISEASES</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mycobacterium</topic><topic>Physiological aspects</topic><topic>Severity of Illness Index</topic><topic>TNF alpha</topic><topic>Tuberculosis</topic><topic>Tuberculosis - blood</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrade Júnior, Dahir Ramos de</creatorcontrib><creatorcontrib>Santos, Sânia Alves dos</creatorcontrib><creatorcontrib>Castro, Isac de</creatorcontrib><creatorcontrib>Andrade, Dahir Ramos de</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale OneFile: Informe Academico</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>The Brazilian journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrade Júnior, Dahir Ramos de</au><au>Santos, Sânia Alves dos</au><au>Castro, Isac de</au><au>Andrade, Dahir Ramos de</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis</atitle><jtitle>The Brazilian journal of infectious diseases</jtitle><addtitle>Braz J Infect Dis</addtitle><date>2008-06</date><risdate>2008</risdate><volume>12</volume><issue>3</issue><spage>226</spage><epage>233</epage><pages>226-233</pages><issn>1413-8670</issn><issn>1678-4391</issn><eissn>1678-4391</eissn><eissn>1413-8670</eissn><abstract>This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 +/- 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 +/- 1495.29 pg/mL) (p<0.05). Patients that lost weight had higher TNF alpha levels (15468.54 +/- 4580.54 pg/mL) than those that didn't loose weight (2904.98 +/- 1367.89) (p<0.05). The levels of TNF alpha were higher in patients with a positive PPD skin test than in those with a negative PPD test (p<0.05). There was a positive correlation between patients' clinical severity and the serum levels of TNF alpha. In patients with successive measurements of TNF alpha, we observed that there was a drop in cytokine levels, and also a clinical improvement concomitantly. We concluded that there was a correlation between serum TNF alpha levels and chest X-Ray alterations, loss of weight, positive PPD skin test and clinical severity in patients with tuberculosis. There was evidence of a worse clinical outcome in patients with tuberculosis that presented higher TNF alpha serum levels.</abstract><cop>Brazil</cop><pub>Contexto</pub><pmid>18833408</pmid><doi>10.1590/s1413-86702008000300013</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biomarkers - blood Case-Control Studies clinical severity cytokines Diagnosis Female Humans INFECTIOUS DISEASES Male Middle Aged Mycobacterium Physiological aspects Severity of Illness Index TNF alpha Tuberculosis Tuberculosis - blood Tumor necrosis factor Tumor Necrosis Factor-alpha - blood Young Adult |
| title | Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis |
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