Survival of patients receiving a liver transplant for hepatocellular carcinoma, and risk of tumor recurrence
The goal of this research has been to evaluate the survival, in long and short term, of the patient receiving liver transplant for hepatocellular carcinoma (HCC), the risk of post-transplant tumor relapse and factors related to this complication. Retrospective study of a consecutive series of patien...
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| Veröffentlicht in: | Revista española de enfermedades digestivas 2006-12, Vol.98 (12), p.899-906 |
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| creator | Pérez de Luque, D López Vallejos, P Montero Alvarez, J L Fraga Rivas, E Barrera Baena, P Costán Rodero, G Rufian Peña, S Díaz Iglesias, C López-Cillero, P Briceño Delgado, J Padillo Ruiz, J Pozo Laderas, J C Marchal Molina, T Solórzano Peck, G de la Mata García, M |
| description | The goal of this research has been to evaluate the survival, in long and short term, of the patient receiving liver transplant for hepatocellular carcinoma (HCC), the risk of post-transplant tumor relapse and factors related to this complication.
Retrospective study of a consecutive series of patients having had liver transplant for HCC.
Transplant patients for HCC from 1989 to November 2003. Patients were selected due to general limitations of nodule size and quantity, which were subsequently published as Milan criteria. Also, criteria agreed in the Conference of Barcelona were followed in the pre-transplant diagnosis.
The survival of this 81 patients group was of the 80, 61 and 52% for 1, 5 and 10 years respectively. In the 32% of the cases the HCC was an incidental finding in the explant. In the 12.3%, the tumor relapse was verified. The multivariate research identified the size of the nodule (OR=1,7944) (IC 95%=1,1332-2,8413) and the vascular invasion (OR=6,6346) (IC 95%=1,4624-30,1003) as risk factors of relapse.
The liver transplant in selected patients with HCC has good results in medium and long term. The risk of post-transplant tumor relapse becomes notably reduced and is associated with the size of the nodule and the microscopic vascular invasion. |
| doi_str_mv | 10.4321/S1130-01082006001200002 |
| format | Article |
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Retrospective study of a consecutive series of patients having had liver transplant for HCC.
Transplant patients for HCC from 1989 to November 2003. Patients were selected due to general limitations of nodule size and quantity, which were subsequently published as Milan criteria. Also, criteria agreed in the Conference of Barcelona were followed in the pre-transplant diagnosis.
The survival of this 81 patients group was of the 80, 61 and 52% for 1, 5 and 10 years respectively. In the 32% of the cases the HCC was an incidental finding in the explant. In the 12.3%, the tumor relapse was verified. The multivariate research identified the size of the nodule (OR=1,7944) (IC 95%=1,1332-2,8413) and the vascular invasion (OR=6,6346) (IC 95%=1,4624-30,1003) as risk factors of relapse.
The liver transplant in selected patients with HCC has good results in medium and long term. The risk of post-transplant tumor relapse becomes notably reduced and is associated with the size of the nodule and the microscopic vascular invasion.</description><identifier>ISSN: 1130-0108</identifier><identifier>EISSN: 1130-0108</identifier><identifier>DOI: 10.4321/S1130-01082006001200002</identifier><identifier>PMID: 17274695</identifier><language>eng</language><publisher>Spain: Sociedad Española de Patología Digestiva</publisher><subject>Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Gastroenterology & Hepatology ; Geriatrics & Gerontology ; Humans ; Infectious Diseases ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation - mortality ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Oncology ; Pathology ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Retrospective Studies ; Risk ; Spain - epidemiology ; Surgery ; Survival Analysis ; Survival Rate ; Treatment Outcome</subject><ispartof>Revista española de enfermedades digestivas, 2006-12, Vol.98 (12), p.899-906</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-31310bb2caa19862a4f70bc0a230661b755d73ecb9a0f6facb345d561f6621de3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,861,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17274695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez de Luque, D</creatorcontrib><creatorcontrib>López Vallejos, P</creatorcontrib><creatorcontrib>Montero Alvarez, J L</creatorcontrib><creatorcontrib>Fraga Rivas, E</creatorcontrib><creatorcontrib>Barrera Baena, P</creatorcontrib><creatorcontrib>Costán Rodero, G</creatorcontrib><creatorcontrib>Rufian Peña, S</creatorcontrib><creatorcontrib>Díaz Iglesias, C</creatorcontrib><creatorcontrib>López-Cillero, P</creatorcontrib><creatorcontrib>Briceño Delgado, J</creatorcontrib><creatorcontrib>Padillo Ruiz, J</creatorcontrib><creatorcontrib>Pozo Laderas, J C</creatorcontrib><creatorcontrib>Marchal Molina, T</creatorcontrib><creatorcontrib>Solórzano Peck, G</creatorcontrib><creatorcontrib>de la Mata García, M</creatorcontrib><title>Survival of patients receiving a liver transplant for hepatocellular carcinoma, and risk of tumor recurrence</title><title>Revista española de enfermedades digestivas</title><addtitle>Rev Esp Enferm Dig</addtitle><description>The goal of this research has been to evaluate the survival, in long and short term, of the patient receiving liver transplant for hepatocellular carcinoma (HCC), the risk of post-transplant tumor relapse and factors related to this complication.
Retrospective study of a consecutive series of patients having had liver transplant for HCC.
Transplant patients for HCC from 1989 to November 2003. Patients were selected due to general limitations of nodule size and quantity, which were subsequently published as Milan criteria. Also, criteria agreed in the Conference of Barcelona were followed in the pre-transplant diagnosis.
The survival of this 81 patients group was of the 80, 61 and 52% for 1, 5 and 10 years respectively. In the 32% of the cases the HCC was an incidental finding in the explant. In the 12.3%, the tumor relapse was verified. The multivariate research identified the size of the nodule (OR=1,7944) (IC 95%=1,1332-2,8413) and the vascular invasion (OR=6,6346) (IC 95%=1,4624-30,1003) as risk factors of relapse.
The liver transplant in selected patients with HCC has good results in medium and long term. The risk of post-transplant tumor relapse becomes notably reduced and is associated with the size of the nodule and the microscopic vascular invasion.</description><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Gastroenterology & Hepatology</subject><subject>Geriatrics & Gerontology</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation - mortality</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Pharmacology & Pharmacy</subject><subject>Radiology, Nuclear Medicine & Medical Imaging</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Spain - epidemiology</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>1130-0108</issn><issn>1130-0108</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UV1LwzAUDaK4Of0Lmief3LxJ2nR9FPELBj5Mn8ttmmpmmsykLfjv7dxQQfDpXrjng3sOIWcMZong7HLJmIApMJhzAAnAhgHA98j4-7D_ax-RoxhXAImQKT8kI5bxLJF5OiZ22YXe9Gipr-kaW6NdG2nQSpveuBeK1JpeB9oGdHFt0bW09oG-6gHrlba2sxiowqCM8w1eUHQVDSa-bfTarhmwg1gXgnZKH5ODGm3UJ7s5Ic-3N0_X99PF493D9dViqgTP26lggkFZcoXI8rnkmNQZlAqQC5CSlVmaVpnQqswRalmjKkWSVqlktZScVVpMyGyrG5XR1hcr3wU3GBZfsRV_YhsI51vCOvj3Tse2aEzcfIdO-y4Wcj4456kcgNkWqIKPMei6WAfTYPgoGBSbZv6xON1ZdGWjqx_ergrxCWPdh-U</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Pérez de Luque, D</creator><creator>López Vallejos, P</creator><creator>Montero Alvarez, J L</creator><creator>Fraga Rivas, E</creator><creator>Barrera Baena, P</creator><creator>Costán Rodero, G</creator><creator>Rufian Peña, S</creator><creator>Díaz Iglesias, C</creator><creator>López-Cillero, P</creator><creator>Briceño Delgado, J</creator><creator>Padillo Ruiz, J</creator><creator>Pozo Laderas, J C</creator><creator>Marchal Molina, T</creator><creator>Solórzano Peck, G</creator><creator>de la Mata García, M</creator><general>Sociedad Española de Patología Digestiva</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>200612</creationdate><title>Survival of patients receiving a liver transplant for hepatocellular carcinoma, and risk of tumor recurrence</title><author>Pérez de Luque, D ; 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Retrospective study of a consecutive series of patients having had liver transplant for HCC.
Transplant patients for HCC from 1989 to November 2003. Patients were selected due to general limitations of nodule size and quantity, which were subsequently published as Milan criteria. Also, criteria agreed in the Conference of Barcelona were followed in the pre-transplant diagnosis.
The survival of this 81 patients group was of the 80, 61 and 52% for 1, 5 and 10 years respectively. In the 32% of the cases the HCC was an incidental finding in the explant. In the 12.3%, the tumor relapse was verified. The multivariate research identified the size of the nodule (OR=1,7944) (IC 95%=1,1332-2,8413) and the vascular invasion (OR=6,6346) (IC 95%=1,4624-30,1003) as risk factors of relapse.
The liver transplant in selected patients with HCC has good results in medium and long term. The risk of post-transplant tumor relapse becomes notably reduced and is associated with the size of the nodule and the microscopic vascular invasion.</abstract><cop>Spain</cop><pub>Sociedad Española de Patología Digestiva</pub><pmid>17274695</pmid><doi>10.4321/S1130-01082006001200002</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Gastroenterology & Hepatology Geriatrics & Gerontology Humans Infectious Diseases Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation - mortality Neoplasm Recurrence, Local Neoplasm Staging Oncology Pathology Pharmacology & Pharmacy Radiology, Nuclear Medicine & Medical Imaging Retrospective Studies Risk Spain - epidemiology Surgery Survival Analysis Survival Rate Treatment Outcome |
| title | Survival of patients receiving a liver transplant for hepatocellular carcinoma, and risk of tumor recurrence |
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