Alteration in liver function tests among patients hospitalized for COVID-19: a multicentric study in Peru
Introduction: COVID-19 affects the liver, causing alteration in liver biochemistry tests such as aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin. Objective: To determine the prevalence of alteration in liver functions tests and associat...
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| Veröffentlicht in: | Revista de gastroenterología del Perú 2021-04, Vol.41 (2), p.86-93 |
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| creator | Marín-Dueñas, Ivania Vega, Jenny Carrillo-Ng, Hugo Veramendi-Schult, Isabel Zavaleta-Alva, Ricardo Vásquez-Elera, Luis Gonzales-Soler, Zeneida Agurto, Hellen S. Tarrillo-Purisaca, Jorge Garavito-Rentería, Jorge Lozano-Miranda, Adelina |
| description | Introduction: COVID-19 affects the liver, causing alteration in liver biochemistry tests such as aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin. Objective: To determine the prevalence of alteration in liver functions tests and associated factors for severity among Peruvian COVID-19 patients. Materials and methods: A descriptive, retrospective and cross-sectional study was performed in 4 public hospitals in Peru. Patients admitted to hospitalization wards and intensive care units with a diagnosis COVID-19 were enrolled. The evaluation of AST, ALT, ALP, total bilirubin and albumin was performed. Associations with demographic and medical data were assessed. Results: 1,100 patients were enrolled, of which 81.7% had altered liver function tests. Only 2.8% of the patients had cirrhosis and 2.1% hepatitis B/C virus. AST and ALT were altered at admission in 64.7% and 63.7%, of the patients respectively. Factors associated with liver injury were: being female OR=0.53 (95% CI: 0.39-0.73; p |
| doi_str_mv | 10.47892/rgp.2021.412.1284 |
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Objective: To determine the prevalence of alteration in liver functions tests and associated factors for severity among Peruvian COVID-19 patients. Materials and methods: A descriptive, retrospective and cross-sectional study was performed in 4 public hospitals in Peru. Patients admitted to hospitalization wards and intensive care units with a diagnosis COVID-19 were enrolled. The evaluation of AST, ALT, ALP, total bilirubin and albumin was performed. Associations with demographic and medical data were assessed. Results: 1,100 patients were enrolled, of which 81.7% had altered liver function tests. Only 2.8% of the patients had cirrhosis and 2.1% hepatitis B/C virus. AST and ALT were altered at admission in 64.7% and 63.7%, of the patients respectively. Factors associated with liver injury were: being female OR=0.53 (95% CI: 0.39-0.73; p<0.01), dyslipidemia OR=1.72 (95% CI: 1.10-2.70; p=0.01), previous medication OR=1.56 (95% CI: 1.12 -2.16, p<0.01) and fever OR=1.43 (95% CI: 1.03-1.199, p=0.03). Disease severity was associated with levels of AST and ALT (p<0.01). Patients taking self-medication OR=1.56 (95% CI: 1.12-2.16; p<0.01) and paracetamol OR= 1.41 (95% CI:1.01-1.98; p=0.04) had higher risk of liver injury. Meanwhile, corticosteroids OR=0.55 (95% CI: 0.38-0.78; p<0.01) and enoxaparin OR=0.53 (95% CI: 0.35- 0.81; p<0.01) were protective factors. Conclusions: Peruvian patients with COVID- teration in liver function tests, high levels of AST and ALT were related to disease severity.]]></description><identifier>ISSN: 1022-5129</identifier><identifier>EISSN: 1609-722X</identifier><identifier>DOI: 10.47892/rgp.2021.412.1284</identifier><language>eng</language><publisher>Sociedad de Gastroenterología del Perú</publisher><subject>GASTROENTEROLOGY & HEPATOLOGY ; HEALTH POLICY & SERVICES ; MEDICAL ETHICS ; MEDICINE, GENERAL & INTERNAL</subject><ispartof>Revista de gastroenterología del Perú, 2021-04, Vol.41 (2), p.86-93</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-8889-1981 ; 0000-0001-6148-4414 ; 0000-0003-0881-5186 ; 0000-0002-9075-5559 ; 0000-0002-6468-8882 ; 0000-0001-7886-8895 ; 0000-0001-7349-0790 ; 0000-0002-2073-3848 ; 0000-0002-5482-596X ; 0000-0001-7883-1355 ; 0000-0002-4355-9643</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids></links><search><creatorcontrib>Marín-Dueñas, Ivania</creatorcontrib><creatorcontrib>Vega, Jenny</creatorcontrib><creatorcontrib>Carrillo-Ng, Hugo</creatorcontrib><creatorcontrib>Veramendi-Schult, Isabel</creatorcontrib><creatorcontrib>Zavaleta-Alva, Ricardo</creatorcontrib><creatorcontrib>Vásquez-Elera, Luis</creatorcontrib><creatorcontrib>Gonzales-Soler, Zeneida</creatorcontrib><creatorcontrib>Agurto, Hellen S.</creatorcontrib><creatorcontrib>Tarrillo-Purisaca, Jorge</creatorcontrib><creatorcontrib>Garavito-Rentería, Jorge</creatorcontrib><creatorcontrib>Lozano-Miranda, Adelina</creatorcontrib><title>Alteration in liver function tests among patients hospitalized for COVID-19: a multicentric study in Peru</title><title>Revista de gastroenterología del Perú</title><addtitle>Rev. gastroenterol. Perú</addtitle><description><![CDATA[Introduction: COVID-19 affects the liver, causing alteration in liver biochemistry tests such as aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin. Objective: To determine the prevalence of alteration in liver functions tests and associated factors for severity among Peruvian COVID-19 patients. Materials and methods: A descriptive, retrospective and cross-sectional study was performed in 4 public hospitals in Peru. Patients admitted to hospitalization wards and intensive care units with a diagnosis COVID-19 were enrolled. The evaluation of AST, ALT, ALP, total bilirubin and albumin was performed. Associations with demographic and medical data were assessed. Results: 1,100 patients were enrolled, of which 81.7% had altered liver function tests. Only 2.8% of the patients had cirrhosis and 2.1% hepatitis B/C virus. AST and ALT were altered at admission in 64.7% and 63.7%, of the patients respectively. Factors associated with liver injury were: being female OR=0.53 (95% CI: 0.39-0.73; p<0.01), dyslipidemia OR=1.72 (95% CI: 1.10-2.70; p=0.01), previous medication OR=1.56 (95% CI: 1.12 -2.16, p<0.01) and fever OR=1.43 (95% CI: 1.03-1.199, p=0.03). Disease severity was associated with levels of AST and ALT (p<0.01). Patients taking self-medication OR=1.56 (95% CI: 1.12-2.16; p<0.01) and paracetamol OR= 1.41 (95% CI:1.01-1.98; p=0.04) had higher risk of liver injury. Meanwhile, corticosteroids OR=0.55 (95% CI: 0.38-0.78; p<0.01) and enoxaparin OR=0.53 (95% CI: 0.35- 0.81; p<0.01) were protective factors. Conclusions: Peruvian patients with COVID- teration in liver function tests, high levels of AST and ALT were related to disease severity.]]></description><subject>GASTROENTEROLOGY & HEPATOLOGY</subject><subject>HEALTH POLICY & SERVICES</subject><subject>MEDICAL ETHICS</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><issn>1022-5129</issn><issn>1609-722X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNotUctOwzAQjBBIlMIPcPKRS4K9TuKEW1VelSoViYe4WY67Ka7SONgJUvl6nJbDah-andXORNE1o0kqihJu3aZLgAJLUgYJgyI9iSYsp2UsAD5PQ00B4oxBeR5deL-lNKUp5JPIzJoeneqNbYlpSWN-0JF6aPVh0qPvPVE7225IF0DYhvbL-s70qjG_uCa1dWS--ljcx6y8I4rshqY3OuCc0cT3w3o_0r6gGy6js1o1Hq_-8zR6f3x4mz_Hy9XTYj5bxpoVWR9XwEWeZ6wErXIFFBUiwyoVZalELajQBVNpTjmoWqw5Mp7xAiuRibpiXFA-jZIjr9cGGyu3dnBtOChfRw3kqMEoFKUUQhR5WLg5LnTOfg_hY7kzXmPTqBbt4CVkJXCWB1EDFI5Q7az3DmvZObNTbi8ZlQcjZDBCjvwyGCFHI_gfiPV57w</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Marín-Dueñas, Ivania</creator><creator>Vega, Jenny</creator><creator>Carrillo-Ng, Hugo</creator><creator>Veramendi-Schult, Isabel</creator><creator>Zavaleta-Alva, Ricardo</creator><creator>Vásquez-Elera, Luis</creator><creator>Gonzales-Soler, Zeneida</creator><creator>Agurto, Hellen S.</creator><creator>Tarrillo-Purisaca, Jorge</creator><creator>Garavito-Rentería, Jorge</creator><creator>Lozano-Miranda, Adelina</creator><general>Sociedad de Gastroenterología del Perú</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope><orcidid>https://orcid.org/0000-0002-8889-1981</orcidid><orcidid>https://orcid.org/0000-0001-6148-4414</orcidid><orcidid>https://orcid.org/0000-0003-0881-5186</orcidid><orcidid>https://orcid.org/0000-0002-9075-5559</orcidid><orcidid>https://orcid.org/0000-0002-6468-8882</orcidid><orcidid>https://orcid.org/0000-0001-7886-8895</orcidid><orcidid>https://orcid.org/0000-0001-7349-0790</orcidid><orcidid>https://orcid.org/0000-0002-2073-3848</orcidid><orcidid>https://orcid.org/0000-0002-5482-596X</orcidid><orcidid>https://orcid.org/0000-0001-7883-1355</orcidid><orcidid>https://orcid.org/0000-0002-4355-9643</orcidid></search><sort><creationdate>20210401</creationdate><title>Alteration in liver function tests among patients hospitalized for COVID-19: a multicentric study in Peru</title><author>Marín-Dueñas, Ivania ; Vega, Jenny ; Carrillo-Ng, Hugo ; Veramendi-Schult, Isabel ; Zavaleta-Alva, Ricardo ; Vásquez-Elera, Luis ; Gonzales-Soler, Zeneida ; Agurto, Hellen S. ; Tarrillo-Purisaca, Jorge ; Garavito-Rentería, Jorge ; Lozano-Miranda, Adelina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c185t-b237665192ca6a20eaee1eb4799a7f707c81a46032af7d3e13538eb757fb13703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>GASTROENTEROLOGY & HEPATOLOGY</topic><topic>HEALTH POLICY & SERVICES</topic><topic>MEDICAL ETHICS</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><toplevel>online_resources</toplevel><creatorcontrib>Marín-Dueñas, Ivania</creatorcontrib><creatorcontrib>Vega, Jenny</creatorcontrib><creatorcontrib>Carrillo-Ng, Hugo</creatorcontrib><creatorcontrib>Veramendi-Schult, Isabel</creatorcontrib><creatorcontrib>Zavaleta-Alva, Ricardo</creatorcontrib><creatorcontrib>Vásquez-Elera, Luis</creatorcontrib><creatorcontrib>Gonzales-Soler, Zeneida</creatorcontrib><creatorcontrib>Agurto, Hellen S.</creatorcontrib><creatorcontrib>Tarrillo-Purisaca, Jorge</creatorcontrib><creatorcontrib>Garavito-Rentería, Jorge</creatorcontrib><creatorcontrib>Lozano-Miranda, Adelina</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Revista de gastroenterología del Perú</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marín-Dueñas, Ivania</au><au>Vega, Jenny</au><au>Carrillo-Ng, Hugo</au><au>Veramendi-Schult, Isabel</au><au>Zavaleta-Alva, Ricardo</au><au>Vásquez-Elera, Luis</au><au>Gonzales-Soler, Zeneida</au><au>Agurto, Hellen S.</au><au>Tarrillo-Purisaca, Jorge</au><au>Garavito-Rentería, Jorge</au><au>Lozano-Miranda, Adelina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration in liver function tests among patients hospitalized for COVID-19: a multicentric study in Peru</atitle><jtitle>Revista de gastroenterología del Perú</jtitle><addtitle>Rev. gastroenterol. Perú</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>41</volume><issue>2</issue><spage>86</spage><epage>93</epage><pages>86-93</pages><issn>1022-5129</issn><eissn>1609-722X</eissn><abstract><![CDATA[Introduction: COVID-19 affects the liver, causing alteration in liver biochemistry tests such as aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin. Objective: To determine the prevalence of alteration in liver functions tests and associated factors for severity among Peruvian COVID-19 patients. Materials and methods: A descriptive, retrospective and cross-sectional study was performed in 4 public hospitals in Peru. Patients admitted to hospitalization wards and intensive care units with a diagnosis COVID-19 were enrolled. The evaluation of AST, ALT, ALP, total bilirubin and albumin was performed. Associations with demographic and medical data were assessed. Results: 1,100 patients were enrolled, of which 81.7% had altered liver function tests. Only 2.8% of the patients had cirrhosis and 2.1% hepatitis B/C virus. AST and ALT were altered at admission in 64.7% and 63.7%, of the patients respectively. Factors associated with liver injury were: being female OR=0.53 (95% CI: 0.39-0.73; p<0.01), dyslipidemia OR=1.72 (95% CI: 1.10-2.70; p=0.01), previous medication OR=1.56 (95% CI: 1.12 -2.16, p<0.01) and fever OR=1.43 (95% CI: 1.03-1.199, p=0.03). Disease severity was associated with levels of AST and ALT (p<0.01). Patients taking self-medication OR=1.56 (95% CI: 1.12-2.16; p<0.01) and paracetamol OR= 1.41 (95% CI:1.01-1.98; p=0.04) had higher risk of liver injury. Meanwhile, corticosteroids OR=0.55 (95% CI: 0.38-0.78; p<0.01) and enoxaparin OR=0.53 (95% CI: 0.35- 0.81; p<0.01) were protective factors. Conclusions: Peruvian patients with COVID- teration in liver function tests, high levels of AST and ALT were related to disease severity.]]></abstract><pub>Sociedad de Gastroenterología del Perú</pub><doi>10.47892/rgp.2021.412.1284</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8889-1981</orcidid><orcidid>https://orcid.org/0000-0001-6148-4414</orcidid><orcidid>https://orcid.org/0000-0003-0881-5186</orcidid><orcidid>https://orcid.org/0000-0002-9075-5559</orcidid><orcidid>https://orcid.org/0000-0002-6468-8882</orcidid><orcidid>https://orcid.org/0000-0001-7886-8895</orcidid><orcidid>https://orcid.org/0000-0001-7349-0790</orcidid><orcidid>https://orcid.org/0000-0002-2073-3848</orcidid><orcidid>https://orcid.org/0000-0002-5482-596X</orcidid><orcidid>https://orcid.org/0000-0001-7883-1355</orcidid><orcidid>https://orcid.org/0000-0002-4355-9643</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | GASTROENTEROLOGY & HEPATOLOGY HEALTH POLICY & SERVICES MEDICAL ETHICS MEDICINE, GENERAL & INTERNAL |
| title | Alteration in liver function tests among patients hospitalized for COVID-19: a multicentric study in Peru |
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