A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION

A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION

A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F254 as stationary phase and toluene: methanol (7:...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the Chilean Chemical Society 2010, Vol.55 (1), p.94-96
Hauptverfasser: PATIL, U. P, GANDHI, S. V, SENGAR, M. R, RAJMANE, V. S
Format: Artikel
Sprache:eng
Schlagworte:
CHEMISTRY, MULTIDISCIPLINARY
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 96
container_issue 1
container_start_page 94
container_title Journal of the Chilean Chemical Society
container_volume 55
creator PATIL, U. P
GANDHI, S. V
SENGAR, M. R
RAJMANE, V. S
description A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F254 as stationary phase and toluene: methanol (7: 3, v/v) as mobile phase. Densitometric evaluation of the separated bands was performed at 280 nm. The two drugs were satisfactorily presolved with Rf values 0.50 ± 0.01 and 0.29 ± 0.00 for Telmisartan and Atorvastatin calcium, respectively. The respective cahbration plots were found to be linear over the range 200-1000 and 200-700 ng/band for Telmisartan and Atorvastatin calcium, respectively. This method has been successfully validated and applied for the analysis of drugs in pharmaceutical formulation.
doi_str_mv 10.4067/S0717-97072010000100022
format Article
fullrecord <record><control><sourceid>scielo_cross</sourceid><recordid>TN_cdi_scielo_journals_S0717_97072010000100022</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S0717_97072010000100022</scielo_id><sourcerecordid>S0717_97072010000100022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c345t-447078497ab8ab515145e79763a4b10c5d9a7e87f4929a9bd4e4e3317d74911d3</originalsourceid><addsrcrecordid>eNp1UNtKxDAQDaLguvoN5ge6Jm3aNI-xFzfQNtBkF30qaZuFXVYrrT7496auiCDOw8xhZs6Z4QBwi9GKoIjeKUQx9RhF1EcYuZiT75-Bxc_g_Be-BFfTdEAo8MMoWoCBwy0vRMp1lsI0q5TQssx0LRLoylqmMJc15BUvnpRQUOZQZ0UpFK81r1w_hVzLesuV5lpUMOFFIjYldDAXj7OkVBlMZHkvKrcgq2twsTPHyd581yXY5JlO1l4hH4Rje11AwjePEPdqTBg1bWzaEIeYhJYyGgWGtBh1Yc8MtTHdEeYzw9qeWGKDANOeEoZxHyzB6qQ7dXt7HJrD8D6-uIPNl13NH7scgZ4I3ThM02h3zeu4fzbjR4NRMxv9L_MTLhFjvA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>PATIL, U. P ; GANDHI, S. V ; SENGAR, M. R ; RAJMANE, V. S</creator><creatorcontrib>PATIL, U. P ; GANDHI, S. V ; SENGAR, M. R ; RAJMANE, V. S</creatorcontrib><description>A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F254 as stationary phase and toluene: methanol (7: 3, v/v) as mobile phase. Densitometric evaluation of the separated bands was performed at 280 nm. The two drugs were satisfactorily presolved with Rf values 0.50 ± 0.01 and 0.29 ± 0.00 for Telmisartan and Atorvastatin calcium, respectively. The respective cahbration plots were found to be linear over the range 200-1000 and 200-700 ng/band for Telmisartan and Atorvastatin calcium, respectively. This method has been successfully validated and applied for the analysis of drugs in pharmaceutical formulation.</description><identifier>ISSN: 0717-9707</identifier><identifier>EISSN: 0717-9707</identifier><identifier>DOI: 10.4067/S0717-97072010000100022</identifier><language>eng</language><publisher>Sociedad Chilena de Química</publisher><subject>CHEMISTRY, MULTIDISCIPLINARY</subject><ispartof>Journal of the Chilean Chemical Society, 2010, Vol.55 (1), p.94-96</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-447078497ab8ab515145e79763a4b10c5d9a7e87f4929a9bd4e4e3317d74911d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,4012,27910,27911,27912</link.rule.ids></links><search><creatorcontrib>PATIL, U. P</creatorcontrib><creatorcontrib>GANDHI, S. V</creatorcontrib><creatorcontrib>SENGAR, M. R</creatorcontrib><creatorcontrib>RAJMANE, V. S</creatorcontrib><title>A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION</title><title>Journal of the Chilean Chemical Society</title><addtitle>J. Chil. Chem. Soc</addtitle><description>A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F254 as stationary phase and toluene: methanol (7: 3, v/v) as mobile phase. Densitometric evaluation of the separated bands was performed at 280 nm. The two drugs were satisfactorily presolved with Rf values 0.50 ± 0.01 and 0.29 ± 0.00 for Telmisartan and Atorvastatin calcium, respectively. The respective cahbration plots were found to be linear over the range 200-1000 and 200-700 ng/band for Telmisartan and Atorvastatin calcium, respectively. This method has been successfully validated and applied for the analysis of drugs in pharmaceutical formulation.</description><subject>CHEMISTRY, MULTIDISCIPLINARY</subject><issn>0717-9707</issn><issn>0717-9707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1UNtKxDAQDaLguvoN5ge6Jm3aNI-xFzfQNtBkF30qaZuFXVYrrT7496auiCDOw8xhZs6Z4QBwi9GKoIjeKUQx9RhF1EcYuZiT75-Bxc_g_Be-BFfTdEAo8MMoWoCBwy0vRMp1lsI0q5TQssx0LRLoylqmMJc15BUvnpRQUOZQZ0UpFK81r1w_hVzLesuV5lpUMOFFIjYldDAXj7OkVBlMZHkvKrcgq2twsTPHyd581yXY5JlO1l4hH4Rje11AwjePEPdqTBg1bWzaEIeYhJYyGgWGtBh1Yc8MtTHdEeYzw9qeWGKDANOeEoZxHyzB6qQ7dXt7HJrD8D6-uIPNl13NH7scgZ4I3ThM02h3zeu4fzbjR4NRMxv9L_MTLhFjvA</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>PATIL, U. P</creator><creator>GANDHI, S. V</creator><creator>SENGAR, M. R</creator><creator>RAJMANE, V. S</creator><general>Sociedad Chilena de Química</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope></search><sort><creationdate>2010</creationdate><title>A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION</title><author>PATIL, U. P ; GANDHI, S. V ; SENGAR, M. R ; RAJMANE, V. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-447078497ab8ab515145e79763a4b10c5d9a7e87f4929a9bd4e4e3317d74911d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>CHEMISTRY, MULTIDISCIPLINARY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PATIL, U. P</creatorcontrib><creatorcontrib>GANDHI, S. V</creatorcontrib><creatorcontrib>SENGAR, M. R</creatorcontrib><creatorcontrib>RAJMANE, V. S</creatorcontrib><collection>CrossRef</collection><collection>SciELO</collection><jtitle>Journal of the Chilean Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PATIL, U. P</au><au>GANDHI, S. V</au><au>SENGAR, M. R</au><au>RAJMANE, V. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION</atitle><jtitle>Journal of the Chilean Chemical Society</jtitle><addtitle>J. Chil. Chem. Soc</addtitle><date>2010</date><risdate>2010</risdate><volume>55</volume><issue>1</issue><spage>94</spage><epage>96</epage><pages>94-96</pages><issn>0717-9707</issn><eissn>0717-9707</eissn><abstract>A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F254 as stationary phase and toluene: methanol (7: 3, v/v) as mobile phase. Densitometric evaluation of the separated bands was performed at 280 nm. The two drugs were satisfactorily presolved with Rf values 0.50 ± 0.01 and 0.29 ± 0.00 for Telmisartan and Atorvastatin calcium, respectively. The respective cahbration plots were found to be linear over the range 200-1000 and 200-700 ng/band for Telmisartan and Atorvastatin calcium, respectively. This method has been successfully validated and applied for the analysis of drugs in pharmaceutical formulation.</abstract><pub>Sociedad Chilena de Química</pub><doi>10.4067/S0717-97072010000100022</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0717-9707
ispartof Journal of the Chilean Chemical Society, 2010, Vol.55 (1), p.94-96
issn 0717-9707
0717-9707
language eng
recordid cdi_scielo_journals_S0717_97072010000100022
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects CHEMISTRY, MULTIDISCIPLINARY
title A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T15%3A03%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-scielo_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20VALIDATED%20DENSITOMETRIC%20METHOD%20FOR%20ANALYSIS%20OF%20TELMISARTAN%20AND%20ATORVASTATIN%20CALCIUM%20IN%20FIXED%20DOSE%20COMBINATION&rft.jtitle=Journal%20of%20the%20Chilean%20Chemical%20Society&rft.au=PATIL,%20U.%20P&rft.date=2010&rft.volume=55&rft.issue=1&rft.spage=94&rft.epage=96&rft.pages=94-96&rft.issn=0717-9707&rft.eissn=0717-9707&rft_id=info:doi/10.4067/S0717-97072010000100022&rft_dat=%3Cscielo_cross%3ES0717_97072010000100022%3C/scielo_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_scielo_id=S0717_97072010000100022&rfr_iscdi=true