The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice
ABSTRACT Neutropenia is one of the adverse effects caused by the administration of chemotherapy drugs. The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) admini...
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description | ABSTRACT Neutropenia is one of the adverse effects caused by the administration of chemotherapy drugs. The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) administered intraperitoneally (i.p.) for 7 consecutive days in adult Swiss albino female. Mice were divided into four groups (n= 8/group): 1. Control (only distilled water i.p.), 2. Cyclophosphamide group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and distilled water daily), 3. Vitamin C group (Vitamin C 50 mg/kg i.p. and distilled water daily), and 4. Cyclophosphamide and Vitamin C group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and vitamin C 50 mg/kg i.p. daily). Vitamin C did not interfere in leukocytes count, but when co-administered with cyclophosphamide, significant interaction was observed, intensifying the neutropenia caused by cyclophosphamide. Vitamin C did not influence body weight during treatment, but groups receiving cyclophosphamide had a significant weight loss from the third day of treatment until the end of experiment compared to the control group. Vitamin C supplementation intensified neutropenia induced by cyclophosphamide and did not prevent weight loss induced by cyclophosphamide in mice. |
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The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) administered intraperitoneally (i.p.) for 7 consecutive days in adult Swiss albino female. Mice were divided into four groups (n= 8/group): 1. Control (only distilled water i.p.), 2. Cyclophosphamide group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and distilled water daily), 3. Vitamin C group (Vitamin C 50 mg/kg i.p. and distilled water daily), and 4. Cyclophosphamide and Vitamin C group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and vitamin C 50 mg/kg i.p. daily). Vitamin C did not interfere in leukocytes count, but when co-administered with cyclophosphamide, significant interaction was observed, intensifying the neutropenia caused by cyclophosphamide. Vitamin C did not influence body weight during treatment, but groups receiving cyclophosphamide had a significant weight loss from the third day of treatment until the end of experiment compared to the control group. Vitamin C supplementation intensified neutropenia induced by cyclophosphamide and did not prevent weight loss induced by cyclophosphamide in mice.</description><identifier>ISSN: 0717-7518</identifier><identifier>EISSN: 0717-7518</identifier><identifier>DOI: 10.4067/s0717-75182019000200168</identifier><language>eng</language><publisher>Sociedad Chilena de Nutrición, Bromatología y Toxicología</publisher><subject>NUTRITION & DIETETICS</subject><ispartof>Revista chilena de nutrición, 2019-04, Vol.46 (2), p.168-173</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Garcia, Rosane Scussel</creatorcontrib><creatorcontrib>Araújo, Évelyn de Souza</creatorcontrib><creatorcontrib>Dambrós, Betina Fernanda</creatorcontrib><creatorcontrib>Schneider, Augusto</creatorcontrib><creatorcontrib>Abib, Renata Torres</creatorcontrib><title>The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice</title><title>Revista chilena de nutrición</title><addtitle>Rev. chil. nutr</addtitle><description>ABSTRACT Neutropenia is one of the adverse effects caused by the administration of chemotherapy drugs. The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) administered intraperitoneally (i.p.) for 7 consecutive days in adult Swiss albino female. Mice were divided into four groups (n= 8/group): 1. Control (only distilled water i.p.), 2. Cyclophosphamide group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and distilled water daily), 3. Vitamin C group (Vitamin C 50 mg/kg i.p. and distilled water daily), and 4. Cyclophosphamide and Vitamin C group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and vitamin C 50 mg/kg i.p. daily). Vitamin C did not interfere in leukocytes count, but when co-administered with cyclophosphamide, significant interaction was observed, intensifying the neutropenia caused by cyclophosphamide. Vitamin C did not influence body weight during treatment, but groups receiving cyclophosphamide had a significant weight loss from the third day of treatment until the end of experiment compared to the control group. Vitamin C supplementation intensified neutropenia induced by cyclophosphamide and did not prevent weight loss induced by cyclophosphamide in mice.</description><subject>NUTRITION & DIETETICS</subject><issn>0717-7518</issn><issn>0717-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kN1KAzEQhYMoWKvPYF5ga2abJruXUvyDghfWG29CfiY0ZTdZNrtC394tFRFEGJiBM98c5hByC2zBmZB3mUmQhVxBVTKoGWMlYyCqMzL7Ec5_zZfkKuf9tCUFLGfkY7tDit6jHWjy9DMMug2Rrmkeu67BFuOgh5AinSriOPSpwxg0DdGNFh01B2oPtkndLuVuN7EOJ422weI1ufC6yXjz3efk_fFhu34uNq9PL-v7TWHLGobCAfeel8wYufKlLCupa8GAgxB-ybE2snJguLHeoQM0rFoZYbEy2nAv63o5J4vT3WwDNknt09jHyVC9HZ9Wf5KZAHkCbJ9y7tGrrg-t7g8KmDpmqvI_5BeBFWlM</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Garcia, Rosane Scussel</creator><creator>Araújo, Évelyn de Souza</creator><creator>Dambrós, Betina Fernanda</creator><creator>Schneider, Augusto</creator><creator>Abib, Renata Torres</creator><general>Sociedad Chilena de Nutrición, Bromatología y Toxicología</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope></search><sort><creationdate>201904</creationdate><title>The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice</title><author>Garcia, Rosane Scussel ; Araújo, Évelyn de Souza ; Dambrós, Betina Fernanda ; Schneider, Augusto ; Abib, Renata Torres</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-d14ff420bb75f27287a96014166f34e9b78d1b4bcfded1eb085b6ce8bab4f7993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>NUTRITION & DIETETICS</topic><toplevel>online_resources</toplevel><creatorcontrib>Garcia, Rosane Scussel</creatorcontrib><creatorcontrib>Araújo, Évelyn de Souza</creatorcontrib><creatorcontrib>Dambrós, Betina Fernanda</creatorcontrib><creatorcontrib>Schneider, Augusto</creatorcontrib><creatorcontrib>Abib, Renata Torres</creatorcontrib><collection>CrossRef</collection><collection>SciELO</collection><jtitle>Revista chilena de nutrición</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia, Rosane Scussel</au><au>Araújo, Évelyn de Souza</au><au>Dambrós, Betina Fernanda</au><au>Schneider, Augusto</au><au>Abib, Renata Torres</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice</atitle><jtitle>Revista chilena de nutrición</jtitle><addtitle>Rev. chil. nutr</addtitle><date>2019-04</date><risdate>2019</risdate><volume>46</volume><issue>2</issue><spage>168</spage><epage>173</epage><pages>168-173</pages><issn>0717-7518</issn><eissn>0717-7518</eissn><abstract>ABSTRACT Neutropenia is one of the adverse effects caused by the administration of chemotherapy drugs. The present study aimed at investigating the effect of vitamin C supplementation in a model of immunosuppression induced by cyclophosphamide in mice. Vitamin C supplementation (50 mg/kg/day) administered intraperitoneally (i.p.) for 7 consecutive days in adult Swiss albino female. Mice were divided into four groups (n= 8/group): 1. Control (only distilled water i.p.), 2. Cyclophosphamide group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and distilled water daily), 3. Vitamin C group (Vitamin C 50 mg/kg i.p. and distilled water daily), and 4. Cyclophosphamide and Vitamin C group (cyclophosphamide i.p. 150 and 100 mg/kg on days 1 and 4, respectively and vitamin C 50 mg/kg i.p. daily). Vitamin C did not interfere in leukocytes count, but when co-administered with cyclophosphamide, significant interaction was observed, intensifying the neutropenia caused by cyclophosphamide. Vitamin C did not influence body weight during treatment, but groups receiving cyclophosphamide had a significant weight loss from the third day of treatment until the end of experiment compared to the control group. Vitamin C supplementation intensified neutropenia induced by cyclophosphamide and did not prevent weight loss induced by cyclophosphamide in mice.</abstract><pub>Sociedad Chilena de Nutrición, Bromatología y Toxicología</pub><doi>10.4067/s0717-75182019000200168</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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title | The effect of vitamin C supplementation on neutropenia induced by cyclophosphamide in mice |
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