CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity
CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still...
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| Veröffentlicht in: | Biocell 2010-08, Vol.34 (2), p.91-94 |
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| creator | Zhou, Liping Guo, Xiaolin Jing, B A Zhao, Lianshuang |
| description | CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration. |
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CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.</description><identifier>ISSN: 0327-9545</identifier><identifier>ISSN: 1667-5746</identifier><identifier>PMID: 20925198</identifier><language>eng</language><publisher>Argentina: Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)</publisher><subject>Animals ; BIOLOGY ; Cell Movement - physiology ; Cell Polarity ; Cell Surface Extensions - metabolism ; Chemokine CXCL12 - immunology ; HL-60 Cells ; Humans ; Hyaluronan Receptors - immunology ; Leukemia, Myeloid, Acute - immunology ; Receptors, CXCR4</subject><ispartof>Biocell, 2010-08, Vol.34 (2), p.91-94</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20925198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Liping</creatorcontrib><creatorcontrib>Guo, Xiaolin</creatorcontrib><creatorcontrib>Jing, B A</creatorcontrib><creatorcontrib>Zhao, Lianshuang</creatorcontrib><title>CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity</title><title>Biocell</title><addtitle>Biocell</addtitle><description>CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.</description><subject>Animals</subject><subject>BIOLOGY</subject><subject>Cell Movement - physiology</subject><subject>Cell Polarity</subject><subject>Cell Surface Extensions - metabolism</subject><subject>Chemokine CXCL12 - immunology</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Hyaluronan Receptors - immunology</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Receptors, CXCR4</subject><issn>0327-9545</issn><issn>1667-5746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UE1PwzAM7QHExuAvoNw4FTlfTXpE5WNIFRwAiVuUJZmUka6laZD270m14YP9ZL1nP_usWAIloqw544viMsYdAANG8UWxIFATjmu5LF6bB8aQj8jvf_vw62wGqPlq2hKTDG0yuaVNmhzqDi703qLg0rfrvEbrtqwAGRcCGvqgRz8drorzrQ7RXZ_qqvh8evxo1mX79vzS3LflQFg9lZzn9di4SlINZquFlYC5kBsAvOW8YowaaWllDLMMwBlnrOGO2dpKzKWgq-LuODcan12pXZ_GfV6o3ueb1XwzAQw5yJx4FtweBcPY_yQXJ9X5OFvXe9enqAQXWPBK1Jl5c2KmTeesGkbf6fGg_n9G_wDTe2Gn</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Zhou, Liping</creator><creator>Guo, Xiaolin</creator><creator>Jing, B A</creator><creator>Zhao, Lianshuang</creator><general>Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20100801</creationdate><title>CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity</title><author>Zhou, Liping ; Guo, Xiaolin ; Jing, B A ; Zhao, Lianshuang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p249t-552511ce683a0cfa7d801578b001f556443c8d36cc4d400ececdc5e4d9d815873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>BIOLOGY</topic><topic>Cell Movement - physiology</topic><topic>Cell Polarity</topic><topic>Cell Surface Extensions - metabolism</topic><topic>Chemokine CXCL12 - immunology</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Hyaluronan Receptors - immunology</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Receptors, CXCR4</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Liping</creatorcontrib><creatorcontrib>Guo, Xiaolin</creatorcontrib><creatorcontrib>Jing, B A</creatorcontrib><creatorcontrib>Zhao, Lianshuang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Biocell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Liping</au><au>Guo, Xiaolin</au><au>Jing, B A</au><au>Zhao, Lianshuang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity</atitle><jtitle>Biocell</jtitle><addtitle>Biocell</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>34</volume><issue>2</issue><spage>91</spage><epage>94</epage><pages>91-94</pages><issn>0327-9545</issn><issn>1667-5746</issn><abstract>CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. 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| ispartof | Biocell, 2010-08, Vol.34 (2), p.91-94 |
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| source | Tech Science Press; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals BIOLOGY Cell Movement - physiology Cell Polarity Cell Surface Extensions - metabolism Chemokine CXCL12 - immunology HL-60 Cells Humans Hyaluronan Receptors - immunology Leukemia, Myeloid, Acute - immunology Receptors, CXCR4 |
| title | CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity |
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