Safety of oral glutamine in the abbreviation of preoperative fasting: a double-blind, controlled, randomized clinical trial
No study so far has tested a beverage containing glutamine 2 h before anesthesia in patients undergoing surgery. The aim of the study was to investigate: 1) the safety of the abbreviation of preoperative fasting to 2 h with a carbohydrate-L-glutamine-rich drink; and 2) the residual gastric volume (R...
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| Veröffentlicht in: | Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral 2011-01, Vol.26 (1), p.86-90 |
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| container_title | Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral |
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| creator | Borges Dock-Nascimento, D Aguilar-Nascimento, J E D Caporossi, C Sepulveda Magalhães Faria, M Bragagnolo, R Caporossi, F Stephan Linetzky Waitzberg, D |
| description | No study so far has tested a beverage containing glutamine 2 h before anesthesia in patients undergoing surgery.
The aim of the study was to investigate: 1) the safety of the abbreviation of preoperative fasting to 2 h with a carbohydrate-L-glutamine-rich drink; and 2) the residual gastric volume (RGV) measured after the induction of anesthesia for laparoscopic cholecystectomies.
Randomized controlled trial with 56 women (42 (17-65) years-old) submitted to elective laparoscopic cholecystectomy. Patients were randomized to receive either conventional preoperative fasting of 8 hours (fasted group, n = 12) or one of three different beverages drunk in the evening before surgery (400 mL) and 2 hours before the initiation of anesthesia (200 mL). The beverages were water (placebo group, n = 12), 12.5% (240 mOsm/L) maltodextrine (carbohydrate group, n = 12) or the latter in addition to 50 g (40 g in the evening drink and 10 g in the morning drink) of L-glutamine (glutamine group, n = 14). A 20 F nasogastric tube was inserted immediately after the induction of general anesthesia to aspirate and measure the RGV.
Fifty patients completed the study. None of the patients had either regurgitation during the induction of anesthesia or postoperative complications. The median (range) of RGV was 6 (0-80) mL. The RGV was similar (p = 0.29) between glutamine group (4.5 [0-15] mL), carbohydrate group (7.0 [0-80] mL), placebo group (8.5 [0-50] mL), and fasted group (5.0 [0-50] mL).
The abbreviation of preoperative fasting to 2 h with carbohydrate and L-glutamine is safe and does not increase the RGV during induction of anesthesia. |
| doi_str_mv | 10.3305/nh.2011.26.1.4993 |
| format | Article |
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The aim of the study was to investigate: 1) the safety of the abbreviation of preoperative fasting to 2 h with a carbohydrate-L-glutamine-rich drink; and 2) the residual gastric volume (RGV) measured after the induction of anesthesia for laparoscopic cholecystectomies.
Randomized controlled trial with 56 women (42 (17-65) years-old) submitted to elective laparoscopic cholecystectomy. Patients were randomized to receive either conventional preoperative fasting of 8 hours (fasted group, n = 12) or one of three different beverages drunk in the evening before surgery (400 mL) and 2 hours before the initiation of anesthesia (200 mL). The beverages were water (placebo group, n = 12), 12.5% (240 mOsm/L) maltodextrine (carbohydrate group, n = 12) or the latter in addition to 50 g (40 g in the evening drink and 10 g in the morning drink) of L-glutamine (glutamine group, n = 14). A 20 F nasogastric tube was inserted immediately after the induction of general anesthesia to aspirate and measure the RGV.
Fifty patients completed the study. None of the patients had either regurgitation during the induction of anesthesia or postoperative complications. The median (range) of RGV was 6 (0-80) mL. The RGV was similar (p = 0.29) between glutamine group (4.5 [0-15] mL), carbohydrate group (7.0 [0-80] mL), placebo group (8.5 [0-50] mL), and fasted group (5.0 [0-50] mL).
The abbreviation of preoperative fasting to 2 h with carbohydrate and L-glutamine is safe and does not increase the RGV during induction of anesthesia.</description><identifier>ISSN: 1699-5198</identifier><identifier>EISSN: 1699-5198</identifier><identifier>DOI: 10.3305/nh.2011.26.1.4993</identifier><identifier>PMID: 21519733</identifier><language>eng</language><publisher>Spain: Grupo Arán</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia ; Cholecystectomy, Laparoscopic ; Dietary Carbohydrates - therapeutic use ; Double-Blind Method ; Fasting - physiology ; Female ; Glutamine - adverse effects ; Glutamine - therapeutic use ; Humans ; Male ; Middle Aged ; Nutrition & Dietetics ; Preoperative Period ; Sample Size ; Stomach - anatomy & histology ; Treatment Outcome ; Young Adult</subject><ispartof>Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral, 2011-01, Vol.26 (1), p.86-90</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21519733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borges Dock-Nascimento, D</creatorcontrib><creatorcontrib>Aguilar-Nascimento, J E D</creatorcontrib><creatorcontrib>Caporossi, C</creatorcontrib><creatorcontrib>Sepulveda Magalhães Faria, M</creatorcontrib><creatorcontrib>Bragagnolo, R</creatorcontrib><creatorcontrib>Caporossi, F Stephan</creatorcontrib><creatorcontrib>Linetzky Waitzberg, D</creatorcontrib><title>Safety of oral glutamine in the abbreviation of preoperative fasting: a double-blind, controlled, randomized clinical trial</title><title>Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral</title><addtitle>Nutr Hosp</addtitle><description>No study so far has tested a beverage containing glutamine 2 h before anesthesia in patients undergoing surgery.
The aim of the study was to investigate: 1) the safety of the abbreviation of preoperative fasting to 2 h with a carbohydrate-L-glutamine-rich drink; and 2) the residual gastric volume (RGV) measured after the induction of anesthesia for laparoscopic cholecystectomies.
Randomized controlled trial with 56 women (42 (17-65) years-old) submitted to elective laparoscopic cholecystectomy. Patients were randomized to receive either conventional preoperative fasting of 8 hours (fasted group, n = 12) or one of three different beverages drunk in the evening before surgery (400 mL) and 2 hours before the initiation of anesthesia (200 mL). The beverages were water (placebo group, n = 12), 12.5% (240 mOsm/L) maltodextrine (carbohydrate group, n = 12) or the latter in addition to 50 g (40 g in the evening drink and 10 g in the morning drink) of L-glutamine (glutamine group, n = 14). A 20 F nasogastric tube was inserted immediately after the induction of general anesthesia to aspirate and measure the RGV.
Fifty patients completed the study. None of the patients had either regurgitation during the induction of anesthesia or postoperative complications. The median (range) of RGV was 6 (0-80) mL. The RGV was similar (p = 0.29) between glutamine group (4.5 [0-15] mL), carbohydrate group (7.0 [0-80] mL), placebo group (8.5 [0-50] mL), and fasted group (5.0 [0-50] mL).
The abbreviation of preoperative fasting to 2 h with carbohydrate and L-glutamine is safe and does not increase the RGV during induction of anesthesia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Cholecystectomy, Laparoscopic</subject><subject>Dietary Carbohydrates - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Fasting - physiology</subject><subject>Female</subject><subject>Glutamine - adverse effects</subject><subject>Glutamine - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutrition & Dietetics</subject><subject>Preoperative Period</subject><subject>Sample Size</subject><subject>Stomach - anatomy & histology</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1699-5198</issn><issn>1699-5198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUE1P3DAQtSqq7kL7A3qpfONCwtj5cNwbWtFSCYkD9BzZ8Ri8cuzUcZAof75ZsUg9jObNzHvzRkPIVwZlVUFzGZ5KDoyVvC1ZWUtZfSBb1kpZNEx2J__hDTmd5z0Al9C1n8iGs7UrqmpLXu-VxfxCo6UxKU8f_ZLV6AJSF2h-Qqq0TvjsVHYxHFhTwjhhWutnpFbN2YXH71RRExftsdDeBXNBhxhyit7jipMKJo7uLxo6rFM3rDY5OeU_k49W-Rm_HPMZ-f3j-mF3U9ze_fy1u7otJl7LXGBrQDRWNh0Xsh0GNKLWWipAC9BoQGO0ao2tUQtsG12tJ1troO6EkkbI6oyUb3vnwaGP_T4uKayG_T1wxnvWMnZ4IwAcAg6C8zfBlOKfBefcj24e0HsVMC5z3wne8EbU9cr8dmQuekTTT8mNKr307w-u_gFyGn4t</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Borges Dock-Nascimento, D</creator><creator>Aguilar-Nascimento, J E D</creator><creator>Caporossi, C</creator><creator>Sepulveda Magalhães Faria, M</creator><creator>Bragagnolo, R</creator><creator>Caporossi, F Stephan</creator><creator>Linetzky Waitzberg, D</creator><general>Grupo Arán</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20110101</creationdate><title>Safety of oral glutamine in the abbreviation of preoperative fasting: a double-blind, controlled, randomized clinical trial</title><author>Borges Dock-Nascimento, D ; Aguilar-Nascimento, J E D ; Caporossi, C ; Sepulveda Magalhães Faria, M ; Bragagnolo, R ; Caporossi, F Stephan ; Linetzky Waitzberg, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p249t-e6d075f9582796cced74bb9a0ef005b0eddba6df4eb7e65b3abbffd0487a9d793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Cholecystectomy, Laparoscopic</topic><topic>Dietary Carbohydrates - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Fasting - physiology</topic><topic>Female</topic><topic>Glutamine - adverse effects</topic><topic>Glutamine - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nutrition & Dietetics</topic><topic>Preoperative Period</topic><topic>Sample Size</topic><topic>Stomach - anatomy & histology</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Borges Dock-Nascimento, D</creatorcontrib><creatorcontrib>Aguilar-Nascimento, J E D</creatorcontrib><creatorcontrib>Caporossi, C</creatorcontrib><creatorcontrib>Sepulveda Magalhães Faria, M</creatorcontrib><creatorcontrib>Bragagnolo, R</creatorcontrib><creatorcontrib>Caporossi, F Stephan</creatorcontrib><creatorcontrib>Linetzky Waitzberg, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borges Dock-Nascimento, D</au><au>Aguilar-Nascimento, J E D</au><au>Caporossi, C</au><au>Sepulveda Magalhães Faria, M</au><au>Bragagnolo, R</au><au>Caporossi, F Stephan</au><au>Linetzky Waitzberg, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety of oral glutamine in the abbreviation of preoperative fasting: a double-blind, controlled, randomized clinical trial</atitle><jtitle>Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral</jtitle><addtitle>Nutr Hosp</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>26</volume><issue>1</issue><spage>86</spage><epage>90</epage><pages>86-90</pages><issn>1699-5198</issn><eissn>1699-5198</eissn><abstract>No study so far has tested a beverage containing glutamine 2 h before anesthesia in patients undergoing surgery.
The aim of the study was to investigate: 1) the safety of the abbreviation of preoperative fasting to 2 h with a carbohydrate-L-glutamine-rich drink; and 2) the residual gastric volume (RGV) measured after the induction of anesthesia for laparoscopic cholecystectomies.
Randomized controlled trial with 56 women (42 (17-65) years-old) submitted to elective laparoscopic cholecystectomy. Patients were randomized to receive either conventional preoperative fasting of 8 hours (fasted group, n = 12) or one of three different beverages drunk in the evening before surgery (400 mL) and 2 hours before the initiation of anesthesia (200 mL). The beverages were water (placebo group, n = 12), 12.5% (240 mOsm/L) maltodextrine (carbohydrate group, n = 12) or the latter in addition to 50 g (40 g in the evening drink and 10 g in the morning drink) of L-glutamine (glutamine group, n = 14). A 20 F nasogastric tube was inserted immediately after the induction of general anesthesia to aspirate and measure the RGV.
Fifty patients completed the study. None of the patients had either regurgitation during the induction of anesthesia or postoperative complications. The median (range) of RGV was 6 (0-80) mL. The RGV was similar (p = 0.29) between glutamine group (4.5 [0-15] mL), carbohydrate group (7.0 [0-80] mL), placebo group (8.5 [0-50] mL), and fasted group (5.0 [0-50] mL).
The abbreviation of preoperative fasting to 2 h with carbohydrate and L-glutamine is safe and does not increase the RGV during induction of anesthesia.</abstract><cop>Spain</cop><pub>Grupo Arán</pub><pmid>21519733</pmid><doi>10.3305/nh.2011.26.1.4993</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral, 2011-01, Vol.26 (1), p.86-90 |
| issn | 1699-5198 1699-5198 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Anesthesia Cholecystectomy, Laparoscopic Dietary Carbohydrates - therapeutic use Double-Blind Method Fasting - physiology Female Glutamine - adverse effects Glutamine - therapeutic use Humans Male Middle Aged Nutrition & Dietetics Preoperative Period Sample Size Stomach - anatomy & histology Treatment Outcome Young Adult |
| title | Safety of oral glutamine in the abbreviation of preoperative fasting: a double-blind, controlled, randomized clinical trial |
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