Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients
The aim of our study was to examine the changes in hypertransaminasemia after weight reduction in obese patients with and without NAFLD and the relation with insulin resistance. A population of 162 obese patients was randomly allocated to two groups: a) diet I (low fat) and b) diet II (low carbohydr...
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| Veröffentlicht in: | Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral 2010-09, Vol.25 (5), p.730-735 |
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| container_title | Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral |
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| creator | de Luis, D A Aller, R Izaola, O Gonzalez Sagrado, M Conde, R |
| description | The aim of our study was to examine the changes in hypertransaminasemia after weight reduction in obese patients with and without NAFLD and the relation with insulin resistance.
A population of 162 obese patients was randomly allocated to two groups: a) diet I (low fat) and b) diet II (low carbohydrate), dieting along 3 months. Patients were classified as group I (n=112) when serum ALT activity was normal or group II (NAFLD, n=30) when serum ALT activity was (>or=43 UI/L).
In control group with diet I, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet I improved the same parameters and glucose, triglycerides, ALT, AST, gamaglutamine transferase levels, too. In control group with diet II, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet II improved the same parameters and glucose, triglycerides, ALT and gamaglutamine transferase levels, without statistical changes in AST.
We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hipertransaminasemia and insulin resistance in NAFLD patients. |
| doi_str_mv | 10.3305/nh.2010.25.5.4643 |
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A population of 162 obese patients was randomly allocated to two groups: a) diet I (low fat) and b) diet II (low carbohydrate), dieting along 3 months. Patients were classified as group I (n=112) when serum ALT activity was normal or group II (NAFLD, n=30) when serum ALT activity was (>or=43 UI/L).
In control group with diet I, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet I improved the same parameters and glucose, triglycerides, ALT, AST, gamaglutamine transferase levels, too. In control group with diet II, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet II improved the same parameters and glucose, triglycerides, ALT and gamaglutamine transferase levels, without statistical changes in AST.
We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hipertransaminasemia and insulin resistance in NAFLD patients.</description><identifier>ISSN: 1699-5198</identifier><identifier>EISSN: 1699-5198</identifier><identifier>DOI: 10.3305/nh.2010.25.5.4643</identifier><identifier>PMID: 21336428</identifier><language>eng</language><publisher>Spain: Grupo Arán</publisher><subject>Adult ; Anthropometry ; Blood Glucose - metabolism ; Body Mass Index ; Cholesterol - blood ; Diet, Reducing ; Eating ; Fatty Liver - diet therapy ; Fatty Liver - enzymology ; Fatty Liver - metabolism ; Female ; Humans ; Insulin Resistance - physiology ; Liver Function Tests ; Male ; Middle Aged ; Nutrition & Dietetics ; Obesity - diet therapy ; Obesity - enzymology ; Obesity - metabolism ; Risk Factors ; Transaminases - blood ; Triglycerides - blood ; Weight Loss - physiology</subject><ispartof>Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral, 2010-09, Vol.25 (5), p.730-735</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c297t-6dd7fd2af045487a4e2c8c6e53608a6e0a14411f5963a316045012987c323eb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21336428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Luis, D A</creatorcontrib><creatorcontrib>Aller, R</creatorcontrib><creatorcontrib>Izaola, O</creatorcontrib><creatorcontrib>Gonzalez Sagrado, M</creatorcontrib><creatorcontrib>Conde, R</creatorcontrib><title>Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients</title><title>Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral</title><addtitle>Nutr Hosp</addtitle><description>The aim of our study was to examine the changes in hypertransaminasemia after weight reduction in obese patients with and without NAFLD and the relation with insulin resistance.
A population of 162 obese patients was randomly allocated to two groups: a) diet I (low fat) and b) diet II (low carbohydrate), dieting along 3 months. Patients were classified as group I (n=112) when serum ALT activity was normal or group II (NAFLD, n=30) when serum ALT activity was (>or=43 UI/L).
In control group with diet I, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet I improved the same parameters and glucose, triglycerides, ALT, AST, gamaglutamine transferase levels, too. In control group with diet II, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet II improved the same parameters and glucose, triglycerides, ALT and gamaglutamine transferase levels, without statistical changes in AST.
We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hipertransaminasemia and insulin resistance in NAFLD patients.</description><subject>Adult</subject><subject>Anthropometry</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Cholesterol - blood</subject><subject>Diet, Reducing</subject><subject>Eating</subject><subject>Fatty Liver - diet therapy</subject><subject>Fatty Liver - enzymology</subject><subject>Fatty Liver - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutrition & Dietetics</subject><subject>Obesity - diet therapy</subject><subject>Obesity - enzymology</subject><subject>Obesity - metabolism</subject><subject>Risk Factors</subject><subject>Transaminases - blood</subject><subject>Triglycerides - blood</subject><subject>Weight Loss - physiology</subject><issn>1699-5198</issn><issn>1699-5198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtP3DAQx62qVXm0H4ALyq2nDX7EjnNEiAISEge4R7PORGvktReP02q_AR-73gISc5iX_78Zaxg7E7xViuuLuGklr4XUrW4706kv7FiYYVhpMdivn_IjdkL0zLkcuDXf2ZEUSplO2mP2ej3P6EqT5qb8Tc3ka5kxlmaz3yUHIWXvahcLNT42JUMk2PoIhNRAnGqTllBfMpKnAtHhQRdThODSJoVKz1DKvgn-D-Y6ibCy_9G0xprtoPi6j36wbzMEwp_v8ZQ9_b5-urpd3T_c3F1d3q-cHPqyMtPUz5OEmXe6sz10KJ11BrUy3IJBDqLrhJj1YBQoYaqMCznY3impcK1OWfs2lpzHkMbntOT6VxofuRRyFEaIw0mr6YOzFfj1BuxyelmQyrj15DAEiJgWGq22fW-NElV5_q5c1lucxl32W8j78ePY6h_2KYET</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>de Luis, D A</creator><creator>Aller, R</creator><creator>Izaola, O</creator><creator>Gonzalez Sagrado, M</creator><creator>Conde, R</creator><general>Grupo Arán</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20100901</creationdate><title>Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients</title><author>de Luis, D A ; Aller, R ; Izaola, O ; Gonzalez Sagrado, M ; Conde, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c297t-6dd7fd2af045487a4e2c8c6e53608a6e0a14411f5963a316045012987c323eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Anthropometry</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Cholesterol - blood</topic><topic>Diet, Reducing</topic><topic>Eating</topic><topic>Fatty Liver - diet therapy</topic><topic>Fatty Liver - enzymology</topic><topic>Fatty Liver - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nutrition & Dietetics</topic><topic>Obesity - diet therapy</topic><topic>Obesity - enzymology</topic><topic>Obesity - metabolism</topic><topic>Risk Factors</topic><topic>Transaminases - blood</topic><topic>Triglycerides - blood</topic><topic>Weight Loss - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>de Luis, D A</creatorcontrib><creatorcontrib>Aller, R</creatorcontrib><creatorcontrib>Izaola, O</creatorcontrib><creatorcontrib>Gonzalez Sagrado, M</creatorcontrib><creatorcontrib>Conde, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Luis, D A</au><au>Aller, R</au><au>Izaola, O</au><au>Gonzalez Sagrado, M</au><au>Conde, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients</atitle><jtitle>Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral</jtitle><addtitle>Nutr Hosp</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>25</volume><issue>5</issue><spage>730</spage><epage>735</epage><pages>730-735</pages><issn>1699-5198</issn><eissn>1699-5198</eissn><abstract>The aim of our study was to examine the changes in hypertransaminasemia after weight reduction in obese patients with and without NAFLD and the relation with insulin resistance.
A population of 162 obese patients was randomly allocated to two groups: a) diet I (low fat) and b) diet II (low carbohydrate), dieting along 3 months. Patients were classified as group I (n=112) when serum ALT activity was normal or group II (NAFLD, n=30) when serum ALT activity was (>or=43 UI/L).
In control group with diet I, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet I improved the same parameters and glucose, triglycerides, ALT, AST, gamaglutamine transferase levels, too. In control group with diet II, BMI, weight, fat mass, waist to hip ratio, waist circumference, systolic pressure, total cholesterol, LDL cholesterol, HOMA and insulin levels decreased. In NAFLD group with diet II improved the same parameters and glucose, triglycerides, ALT and gamaglutamine transferase levels, without statistical changes in AST.
We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hipertransaminasemia and insulin resistance in NAFLD patients.</abstract><cop>Spain</cop><pub>Grupo Arán</pub><pmid>21336428</pmid><doi>10.3305/nh.2010.25.5.4643</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Anthropometry Blood Glucose - metabolism Body Mass Index Cholesterol - blood Diet, Reducing Eating Fatty Liver - diet therapy Fatty Liver - enzymology Fatty Liver - metabolism Female Humans Insulin Resistance - physiology Liver Function Tests Male Middle Aged Nutrition & Dietetics Obesity - diet therapy Obesity - enzymology Obesity - metabolism Risk Factors Transaminases - blood Triglycerides - blood Weight Loss - physiology |
| title | Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients |
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