Effect of calcium acetate/magnesium carbonate in the treatment of hyperphosphataemia in dialysis patients in real clinical practice. One year follow up
This observational study was conducted to investigate the use and effectiveness of calcium acetate/magnesium carbonate (CaMg) in the treatment of hyperphosphataemia in dialysis patients in real-world clinical practice. 120 adult CKD patients on dialysis who received CaMg alone or in combination with...
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| Veröffentlicht in: | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 2014, Vol.34 (5), p.617-627 |
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| creator | de Francisco, Angel L M Belmar, Lara Piñera, Celestino Kislikova, María Seras, Miguel Serrano, Mara Albines, Zoila Sango, Cristina Arias, Manuel |
| description | This observational study was conducted to investigate the use and effectiveness of calcium acetate/magnesium carbonate (CaMg) in the treatment of hyperphosphataemia in dialysis patients in real-world clinical practice.
120 adult CKD patients on dialysis who received CaMg alone or in combination with other phosphate binders were followed-up for 3-12 months. Serum phosphorus, calcium, magnesium, parathyroid hormone and albumin concentration was measured at baseline and after 3, 6 and 12 months respectively. In addition, CaMg dosage, use of concurrent phosphate binders, vitamin D and cinacalcet was documented. Patients were evaluated in 2 subgroups - CaMg alone (n=79) vs. CaMg + concurrent phosphate binder (n=41).
In both subgroups serum phosphorus levels decreased significantly from baseline at 3, 6 and 12 months of CaMg treatment. The percentage achievement of recommended serum phosphorus targets improved after CaMg initiation. At month 6, a total of 78% were within the Kidney Disease Outcomes Quality Initiative (K/DOQI) target range. Total corrected serum calcium increased during CaMg treatment, but mildly exceeded the upper limit of normal in three patients only. Asymptomatic significant increases in magnesium (p2.6mg/mL, 1.05mmol/L).
This analysis of current clinical practice shows that - consistent with findings from a randomised controlled trial - CaMg treatment leads to marked improvement in serum phosphorus levels, helping patients in trying to achieve K/DOQI and KDIGO (Kidney Disease Improving Global Outcome) targets. |
| doi_str_mv | 10.3265/Nefrologia.pre2014.Jul.12527 |
| format | Article |
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120 adult CKD patients on dialysis who received CaMg alone or in combination with other phosphate binders were followed-up for 3-12 months. Serum phosphorus, calcium, magnesium, parathyroid hormone and albumin concentration was measured at baseline and after 3, 6 and 12 months respectively. In addition, CaMg dosage, use of concurrent phosphate binders, vitamin D and cinacalcet was documented. Patients were evaluated in 2 subgroups - CaMg alone (n=79) vs. CaMg + concurrent phosphate binder (n=41).
In both subgroups serum phosphorus levels decreased significantly from baseline at 3, 6 and 12 months of CaMg treatment. The percentage achievement of recommended serum phosphorus targets improved after CaMg initiation. At month 6, a total of 78% were within the Kidney Disease Outcomes Quality Initiative (K/DOQI) target range. Total corrected serum calcium increased during CaMg treatment, but mildly exceeded the upper limit of normal in three patients only. Asymptomatic significant increases in magnesium (p<0.001) were observed in the monotherapy group at 3, 6 and 12 months. A total of 80 patients (67%) experienced episodes of mild hypermagnesaemia (>2.6mg/mL, 1.05mmol/L).
This analysis of current clinical practice shows that - consistent with findings from a randomised controlled trial - CaMg treatment leads to marked improvement in serum phosphorus levels, helping patients in trying to achieve K/DOQI and KDIGO (Kidney Disease Improving Global Outcome) targets.</description><identifier>ISSN: 1989-2284</identifier><identifier>EISSN: 1989-2284</identifier><identifier>DOI: 10.3265/Nefrologia.pre2014.Jul.12527</identifier><identifier>PMID: 25259817</identifier><language>eng</language><publisher>Spain: Sociedad Española de Nefrología</publisher><subject>Acetates - therapeutic use ; Calcium Compounds - therapeutic use ; Female ; Follow-Up Studies ; Humans ; Hyperphosphatemia - drug therapy ; Magnesium - therapeutic use ; Male ; Middle Aged ; Prospective Studies ; Renal Dialysis ; Time Factors ; Treatment Outcome ; Urology & Nephrology</subject><ispartof>Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2014, Vol.34 (5), p.617-627</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-10342ddae1cd43485e9d93bf20dd838e7be25c33e2f9c3fff4993a0aa9dcab003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25259817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Francisco, Angel L M</creatorcontrib><creatorcontrib>Belmar, Lara</creatorcontrib><creatorcontrib>Piñera, Celestino</creatorcontrib><creatorcontrib>Kislikova, María</creatorcontrib><creatorcontrib>Seras, Miguel</creatorcontrib><creatorcontrib>Serrano, Mara</creatorcontrib><creatorcontrib>Albines, Zoila</creatorcontrib><creatorcontrib>Sango, Cristina</creatorcontrib><creatorcontrib>Arias, Manuel</creatorcontrib><title>Effect of calcium acetate/magnesium carbonate in the treatment of hyperphosphataemia in dialysis patients in real clinical practice. One year follow up</title><title>Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia</title><addtitle>Nefrologia</addtitle><description>This observational study was conducted to investigate the use and effectiveness of calcium acetate/magnesium carbonate (CaMg) in the treatment of hyperphosphataemia in dialysis patients in real-world clinical practice.
120 adult CKD patients on dialysis who received CaMg alone or in combination with other phosphate binders were followed-up for 3-12 months. Serum phosphorus, calcium, magnesium, parathyroid hormone and albumin concentration was measured at baseline and after 3, 6 and 12 months respectively. In addition, CaMg dosage, use of concurrent phosphate binders, vitamin D and cinacalcet was documented. Patients were evaluated in 2 subgroups - CaMg alone (n=79) vs. CaMg + concurrent phosphate binder (n=41).
In both subgroups serum phosphorus levels decreased significantly from baseline at 3, 6 and 12 months of CaMg treatment. The percentage achievement of recommended serum phosphorus targets improved after CaMg initiation. At month 6, a total of 78% were within the Kidney Disease Outcomes Quality Initiative (K/DOQI) target range. Total corrected serum calcium increased during CaMg treatment, but mildly exceeded the upper limit of normal in three patients only. Asymptomatic significant increases in magnesium (p<0.001) were observed in the monotherapy group at 3, 6 and 12 months. A total of 80 patients (67%) experienced episodes of mild hypermagnesaemia (>2.6mg/mL, 1.05mmol/L).
This analysis of current clinical practice shows that - consistent with findings from a randomised controlled trial - CaMg treatment leads to marked improvement in serum phosphorus levels, helping patients in trying to achieve K/DOQI and KDIGO (Kidney Disease Improving Global Outcome) targets.</description><subject>Acetates - therapeutic use</subject><subject>Calcium Compounds - therapeutic use</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hyperphosphatemia - drug therapy</subject><subject>Magnesium - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Renal Dialysis</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Urology & Nephrology</subject><issn>1989-2284</issn><issn>1989-2284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1O3TAQhS1EVRDlFSovuujmBv8kufGyQlBACBa062hij7lGTuzajtB9El63CT8Si9GMjr4zRzqE_OCskqJtzu7QpuDDo4MqJhSM19XN7CsuGrE9IMdcdWojRFcffrqPyGnObmCyrVnXcfaVHC14ozq-PSYvF9aiLjRYqsFrN48UNBYoeDbC44R5VTSkIUyLRt1Eyw5pSQhlxOnVt9tHTHEXctxBARwdrJhx4PfZZRqhuIXMq7jYPNXeTW4JozGBLk5jRe8npHuERG3wPjzTOX4jXyz4jKfv-4T8vbz4c361ub3_fX3-63ajJVNlw5mshTGAXJta1l2Dyig5WMGM6WSH2wFFo6VEYZWW1tpaKQkMQBkNA2PyhFRvf7N26EP_FOY0LYH9AxOc961SzdoyY6xZhvPF8PPNEFP4N2Mu_eiyRu9hwjDnnrdCsJaz7Yp-f0fnYUTTx-RGSPv-o335H9BJjjA</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>de Francisco, Angel L M</creator><creator>Belmar, Lara</creator><creator>Piñera, Celestino</creator><creator>Kislikova, María</creator><creator>Seras, Miguel</creator><creator>Serrano, Mara</creator><creator>Albines, Zoila</creator><creator>Sango, Cristina</creator><creator>Arias, Manuel</creator><general>Sociedad Española de Nefrología</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>2014</creationdate><title>Effect of calcium acetate/magnesium carbonate in the treatment of hyperphosphataemia in dialysis patients in real clinical practice. One year follow up</title><author>de Francisco, Angel L M ; Belmar, Lara ; Piñera, Celestino ; Kislikova, María ; Seras, Miguel ; Serrano, Mara ; Albines, Zoila ; Sango, Cristina ; Arias, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-10342ddae1cd43485e9d93bf20dd838e7be25c33e2f9c3fff4993a0aa9dcab003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetates - therapeutic use</topic><topic>Calcium Compounds - therapeutic use</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hyperphosphatemia - drug therapy</topic><topic>Magnesium - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Renal Dialysis</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Urology & Nephrology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Francisco, Angel L M</creatorcontrib><creatorcontrib>Belmar, Lara</creatorcontrib><creatorcontrib>Piñera, Celestino</creatorcontrib><creatorcontrib>Kislikova, María</creatorcontrib><creatorcontrib>Seras, Miguel</creatorcontrib><creatorcontrib>Serrano, Mara</creatorcontrib><creatorcontrib>Albines, Zoila</creatorcontrib><creatorcontrib>Sango, Cristina</creatorcontrib><creatorcontrib>Arias, Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Francisco, Angel L M</au><au>Belmar, Lara</au><au>Piñera, Celestino</au><au>Kislikova, María</au><au>Seras, Miguel</au><au>Serrano, Mara</au><au>Albines, Zoila</au><au>Sango, Cristina</au><au>Arias, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of calcium acetate/magnesium carbonate in the treatment of hyperphosphataemia in dialysis patients in real clinical practice. One year follow up</atitle><jtitle>Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia</jtitle><addtitle>Nefrologia</addtitle><date>2014</date><risdate>2014</risdate><volume>34</volume><issue>5</issue><spage>617</spage><epage>627</epage><pages>617-627</pages><issn>1989-2284</issn><eissn>1989-2284</eissn><abstract>This observational study was conducted to investigate the use and effectiveness of calcium acetate/magnesium carbonate (CaMg) in the treatment of hyperphosphataemia in dialysis patients in real-world clinical practice.
120 adult CKD patients on dialysis who received CaMg alone or in combination with other phosphate binders were followed-up for 3-12 months. Serum phosphorus, calcium, magnesium, parathyroid hormone and albumin concentration was measured at baseline and after 3, 6 and 12 months respectively. In addition, CaMg dosage, use of concurrent phosphate binders, vitamin D and cinacalcet was documented. Patients were evaluated in 2 subgroups - CaMg alone (n=79) vs. CaMg + concurrent phosphate binder (n=41).
In both subgroups serum phosphorus levels decreased significantly from baseline at 3, 6 and 12 months of CaMg treatment. The percentage achievement of recommended serum phosphorus targets improved after CaMg initiation. At month 6, a total of 78% were within the Kidney Disease Outcomes Quality Initiative (K/DOQI) target range. Total corrected serum calcium increased during CaMg treatment, but mildly exceeded the upper limit of normal in three patients only. Asymptomatic significant increases in magnesium (p<0.001) were observed in the monotherapy group at 3, 6 and 12 months. A total of 80 patients (67%) experienced episodes of mild hypermagnesaemia (>2.6mg/mL, 1.05mmol/L).
This analysis of current clinical practice shows that - consistent with findings from a randomised controlled trial - CaMg treatment leads to marked improvement in serum phosphorus levels, helping patients in trying to achieve K/DOQI and KDIGO (Kidney Disease Improving Global Outcome) targets.</abstract><cop>Spain</cop><pub>Sociedad Española de Nefrología</pub><pmid>25259817</pmid><doi>10.3265/Nefrologia.pre2014.Jul.12527</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2014, Vol.34 (5), p.617-627 |
| issn | 1989-2284 1989-2284 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acetates - therapeutic use Calcium Compounds - therapeutic use Female Follow-Up Studies Humans Hyperphosphatemia - drug therapy Magnesium - therapeutic use Male Middle Aged Prospective Studies Renal Dialysis Time Factors Treatment Outcome Urology & Nephrology |
| title | Effect of calcium acetate/magnesium carbonate in the treatment of hyperphosphataemia in dialysis patients in real clinical practice. One year follow up |
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