Homocysteine: cardiovascular risk factor in children and adolescents?
The aim of this study was to identify publications in literature that investigated Homocysteine (He) as a risk factor for CVD among children and adolescents. An active search for information in LILACS, IBECS, Science Direct, Medline and Cochrane Library databases was conducted using the following co...
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| Veröffentlicht in: | Revista da Associacao Medica Brasileira (1992) 2013-11, Vol.59 (6), p.622-628 |
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| container_title | Revista da Associacao Medica Brasileira (1992) |
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| creator | Amorim De Farias Leal, Adriana Camêlo Palmeira, Ástrid Menezes Almeida De Castro, Gabriella Oliveira Da Silva Simões, Mônica Teixeira Ramos, Alessandra Medeiros, Carla Campos Muniz |
| description | The aim of this study was to identify publications in literature that investigated Homocysteine (He) as a risk factor for CVD among children and adolescents. An active search for information in LILACS, IBECS, Science Direct, Medline and Cochrane Library databases was conducted using the following combination of keywords “homocysteine”, “cardiovascular diseases”, “child” and “adolescent”. Fifteen articles were analyzed showing direct relationship with increasing age (8 studies) and male gender (10 studies), and an inverse relationship with serum vitamins B6, B12 and folate levels. Thus, the results suggest that more research must be carried through in order to determine in a more coherent way the causes of the hiperhomocisteinemia in the pediatric population, guiding for an adequate diet, rich in nutrients necessary to favor the metabolism of the He.
O objetivo do estudo foi identificar na literatura publicações que investigaram a Homocisteína (He) como um fator de risco para doenças cardiovasculares na faixa etária de crianças e adolescentes. Realizou-se uma busca ativa de informações nas bases de dados LILACS e IBECS, Science Direct, Medline e Biblioteca Cochrane, utilizando-se a combinação dos descritores “homocysteine”, “cardiovascular diseases”, “child” e “adolescent”. Foram analisados 15 artigos, os quais apontaram relação direta dos níveis de He com o sexo masculino (10 estudos) e com o aumento da idade (8 estudos), e uma relação inversa com os níveis séricos das vitaminas B6, B12 e folatos (10 estudos). Sugere-se que sejam realizadas mais pesquisas a fim de determinar de maneira mais coerente as causas da hiperhomocisteinemia na população pediátrica, orientando para uma dieta adequada e rica em nutrientes necessários para favorecer o metabolismo da He. |
| doi_str_mv | 10.1016/j.ramb.2013.05.004 |
| format | Magazinearticle |
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O objetivo do estudo foi identificar na literatura publicações que investigaram a Homocisteína (He) como um fator de risco para doenças cardiovasculares na faixa etária de crianças e adolescentes. Realizou-se uma busca ativa de informações nas bases de dados LILACS e IBECS, Science Direct, Medline e Biblioteca Cochrane, utilizando-se a combinação dos descritores “homocysteine”, “cardiovascular diseases”, “child” e “adolescent”. Foram analisados 15 artigos, os quais apontaram relação direta dos níveis de He com o sexo masculino (10 estudos) e com o aumento da idade (8 estudos), e uma relação inversa com os níveis séricos das vitaminas B6, B12 e folatos (10 estudos). Sugere-se que sejam realizadas mais pesquisas a fim de determinar de maneira mais coerente as causas da hiperhomocisteinemia na população pediátrica, orientando para uma dieta adequada e rica em nutrientes necessários para favorecer o metabolismo da He.</description><identifier>ISSN: 0104-4230</identifier><identifier>ISSN: 1806-9282</identifier><identifier>EISSN: 1806-9282</identifier><identifier>DOI: 10.1016/j.ramb.2013.05.004</identifier><identifier>PMID: 24182942</identifier><language>eng</language><publisher>Brazil: Elsevier Editora Ltda</publisher><subject>Adolescent ; Adolescentes ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Case-Control Studies ; Child ; Child, Preschool ; Cohort Studies ; Crianças ; Cross-Sectional Studies ; Doenças cardiovasculares ; Evidence-Based Medicine ; Female ; Homocisteína ; Homocysteine ; Homocysteine - blood ; Humans ; Infant ; Male ; MEDICINE, GENERAL & INTERNAL ; Risk Factors ; Sex Factors ; Vitamin B 12 - blood ; Vitamin B 6 - blood ; Young Adult</subject><ispartof>Revista da Associacao Medica Brasileira (1992), 2013-11, Vol.59 (6), p.622-628</ispartof><rights>2012 Elsevier Editora Ltda.</rights><rights>Copyright © 2012 Elsevier Editora Ltda. All rights reserved.</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-20eeca56dc529b7fbccb058a39600710c39554315f34359ffa71747a3e45ea853</citedby><cites>FETCH-LOGICAL-c439t-20eeca56dc529b7fbccb058a39600710c39554315f34359ffa71747a3e45ea853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,784,885,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24182942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amorim De Farias Leal, Adriana</creatorcontrib><creatorcontrib>Camêlo Palmeira, Ástrid</creatorcontrib><creatorcontrib>Menezes Almeida De Castro, Gabriella</creatorcontrib><creatorcontrib>Oliveira Da Silva Simões, Mônica</creatorcontrib><creatorcontrib>Teixeira Ramos, Alessandra</creatorcontrib><creatorcontrib>Medeiros, Carla Campos Muniz</creatorcontrib><title>Homocysteine: cardiovascular risk factor in children and adolescents?</title><title>Revista da Associacao Medica Brasileira (1992)</title><addtitle>Rev Assoc Med Bras (1992)</addtitle><description>The aim of this study was to identify publications in literature that investigated Homocysteine (He) as a risk factor for CVD among children and adolescents. An active search for information in LILACS, IBECS, Science Direct, Medline and Cochrane Library databases was conducted using the following combination of keywords “homocysteine”, “cardiovascular diseases”, “child” and “adolescent”. Fifteen articles were analyzed showing direct relationship with increasing age (8 studies) and male gender (10 studies), and an inverse relationship with serum vitamins B6, B12 and folate levels. Thus, the results suggest that more research must be carried through in order to determine in a more coherent way the causes of the hiperhomocisteinemia in the pediatric population, guiding for an adequate diet, rich in nutrients necessary to favor the metabolism of the He.
O objetivo do estudo foi identificar na literatura publicações que investigaram a Homocisteína (He) como um fator de risco para doenças cardiovasculares na faixa etária de crianças e adolescentes. Realizou-se uma busca ativa de informações nas bases de dados LILACS e IBECS, Science Direct, Medline e Biblioteca Cochrane, utilizando-se a combinação dos descritores “homocysteine”, “cardiovascular diseases”, “child” e “adolescent”. Foram analisados 15 artigos, os quais apontaram relação direta dos níveis de He com o sexo masculino (10 estudos) e com o aumento da idade (8 estudos), e uma relação inversa com os níveis séricos das vitaminas B6, B12 e folatos (10 estudos). Sugere-se que sejam realizadas mais pesquisas a fim de determinar de maneira mais coerente as causas da hiperhomocisteinemia na população pediátrica, orientando para uma dieta adequada e rica em nutrientes necessários para favorecer o metabolismo da He.</description><subject>Adolescent</subject><subject>Adolescentes</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Crianças</subject><subject>Cross-Sectional Studies</subject><subject>Doenças cardiovasculares</subject><subject>Evidence-Based Medicine</subject><subject>Female</subject><subject>Homocisteína</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 6 - blood</subject><subject>Young Adult</subject><issn>0104-4230</issn><issn>1806-9282</issn><issn>1806-9282</issn><fulltext>true</fulltext><rsrctype>magazinearticle</rsrctype><creationdate>2013</creationdate><recordtype>magazinearticle</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOo6-gAvp0k3rya0XEUQGbyC4UNchTU8xY9to0grz9qaMunR1Nv_tfIScUMgo0Px8nXnd1xkDyjOQGYDYIQtaQp5WrGS7ZAEURCoYhwNyGMIagBW8ovvkgAlaskqwBbm5d70zmzCiHfAiMdo31n3pYKZO-8Tb8J602ozOJ3ZIzJvtGo9Doocm0Y3rMBgcxnB1RPZa3QU8_rlL8np787K6Tx-f7h5W14-pEbwaUwaIRsu8MZJVddHWxtQgS82rHKCgYHglpeBUtlxwWbWtLmghCs1RSNSl5EuSbXODsdg5tXaTH2Khep5fVfOrMw0AiIFAy2g42xo-vPucMIyqt3Fz1-kB3RQUFXkBBTCaRynbSo13IXhs1Ye3vfYbRUHNvNVazbzV3KBAqsg7mk5_8qe6x-bP8gs4Ci63AoxYvix6NU8fDDbWoxlV4-x_-d-C0Y3F</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Amorim De Farias Leal, Adriana</creator><creator>Camêlo Palmeira, Ástrid</creator><creator>Menezes Almeida De Castro, Gabriella</creator><creator>Oliveira Da Silva Simões, Mônica</creator><creator>Teixeira Ramos, Alessandra</creator><creator>Medeiros, Carla Campos Muniz</creator><general>Elsevier Editora Ltda</general><general>Associação Médica Brasileira</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20131101</creationdate><title>Homocysteine: cardiovascular risk factor in children and adolescents?</title><author>Amorim De Farias Leal, Adriana ; Camêlo Palmeira, Ástrid ; Menezes Almeida De Castro, Gabriella ; Oliveira Da Silva Simões, Mônica ; Teixeira Ramos, Alessandra ; Medeiros, Carla Campos Muniz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-20eeca56dc529b7fbccb058a39600710c39554315f34359ffa71747a3e45ea853</frbrgroupid><rsrctype>magazinearticle</rsrctype><prefilter>magazinearticle</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adolescentes</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Crianças</topic><topic>Cross-Sectional Studies</topic><topic>Doenças cardiovasculares</topic><topic>Evidence-Based Medicine</topic><topic>Female</topic><topic>Homocisteína</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 6 - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amorim De Farias Leal, Adriana</creatorcontrib><creatorcontrib>Camêlo Palmeira, Ástrid</creatorcontrib><creatorcontrib>Menezes Almeida De Castro, Gabriella</creatorcontrib><creatorcontrib>Oliveira Da Silva Simões, Mônica</creatorcontrib><creatorcontrib>Teixeira Ramos, Alessandra</creatorcontrib><creatorcontrib>Medeiros, Carla Campos Muniz</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Revista da Associacao Medica Brasileira (1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amorim De Farias Leal, Adriana</au><au>Camêlo Palmeira, Ástrid</au><au>Menezes Almeida De Castro, Gabriella</au><au>Oliveira Da Silva Simões, Mônica</au><au>Teixeira Ramos, Alessandra</au><au>Medeiros, Carla Campos Muniz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocysteine: cardiovascular risk factor in children and adolescents?</atitle><jtitle>Revista da Associacao Medica Brasileira (1992)</jtitle><addtitle>Rev Assoc Med Bras (1992)</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>59</volume><issue>6</issue><spage>622</spage><epage>628</epage><pages>622-628</pages><issn>0104-4230</issn><issn>1806-9282</issn><eissn>1806-9282</eissn><abstract>The aim of this study was to identify publications in literature that investigated Homocysteine (He) as a risk factor for CVD among children and adolescents. An active search for information in LILACS, IBECS, Science Direct, Medline and Cochrane Library databases was conducted using the following combination of keywords “homocysteine”, “cardiovascular diseases”, “child” and “adolescent”. Fifteen articles were analyzed showing direct relationship with increasing age (8 studies) and male gender (10 studies), and an inverse relationship with serum vitamins B6, B12 and folate levels. Thus, the results suggest that more research must be carried through in order to determine in a more coherent way the causes of the hiperhomocisteinemia in the pediatric population, guiding for an adequate diet, rich in nutrients necessary to favor the metabolism of the He.
O objetivo do estudo foi identificar na literatura publicações que investigaram a Homocisteína (He) como um fator de risco para doenças cardiovasculares na faixa etária de crianças e adolescentes. Realizou-se uma busca ativa de informações nas bases de dados LILACS e IBECS, Science Direct, Medline e Biblioteca Cochrane, utilizando-se a combinação dos descritores “homocysteine”, “cardiovascular diseases”, “child” e “adolescent”. Foram analisados 15 artigos, os quais apontaram relação direta dos níveis de He com o sexo masculino (10 estudos) e com o aumento da idade (8 estudos), e uma relação inversa com os níveis séricos das vitaminas B6, B12 e folatos (10 estudos). Sugere-se que sejam realizadas mais pesquisas a fim de determinar de maneira mais coerente as causas da hiperhomocisteinemia na população pediátrica, orientando para uma dieta adequada e rica em nutrientes necessários para favorecer o metabolismo da He.</abstract><cop>Brazil</cop><pub>Elsevier Editora Ltda</pub><pmid>24182942</pmid><doi>10.1016/j.ramb.2013.05.004</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adolescentes Cardiovascular diseases Cardiovascular Diseases - etiology Case-Control Studies Child Child, Preschool Cohort Studies Crianças Cross-Sectional Studies Doenças cardiovasculares Evidence-Based Medicine Female Homocisteína Homocysteine Homocysteine - blood Humans Infant Male MEDICINE, GENERAL & INTERNAL Risk Factors Sex Factors Vitamin B 12 - blood Vitamin B 6 - blood Young Adult |
| title | Homocysteine: cardiovascular risk factor in children and adolescents? |
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