Effects of dorzolamide/timolol and tafluprost on intraocular pressure and pupil diameter in healthy dogs
This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed at...
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| creator | Dower, Nathalie Moro Bassil Ribeiro, Alexandre Pinto Maciel, Camila do Espirito Santo Spiller, Paulo Roberto Monteiro, Geovanna Barreira Pizzinatto, Fábio Dumit Yamauchi, Kelly Cristiane Ito |
| description | This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed at 8, 11, 14, 17, and 20h. Parameters were evaluated during baseline, treatment period of four days, and one day of post-treatment. During treatment phase, IOP decreased by 0.74 (P |
| doi_str_mv | 10.1590/0103-8478cr20160959 |
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RESUMO: O estudo objetivou avaliar e comparar os efeitos da combinação fixa da dorzolamida/timolol com os da tafluprosta sobre a pressão intraocular (PIO) e o diâmetro pupilar (DP) em cães saudáveis (n=10). Dois experimentos com intervalo de 30 dias foram conduzidos. Em ambos, a PIO e o DP foram avaliados às 8, 11, 14, 17 e às 20h. Os parâmetros foram avaliados durante a fases basal, um período de tratamento de quatro dias, e um dia de pós-tratamento. Durante a fase de tratamento, a PIO dos olhos tratados com dorzolamida/timolol reduziram em 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), e 3.10mmHg (P<0.01); e dos olhos tratados com tafluprosta em 1.50, 2.18, 2.14 e 2.18mmHg (P<0.001). O DP dos olhos tratados com dorzolamida/timolol reduziram em 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001) e 0.40mm (P<0.001); e dos olhos tratados com tafluprosta em 2.31, 2.55, 2.43 e 2.70mm (P<0.001). A dorzolamida/timol e a tafluprosta foram capazes de reduzir a PIO e o DP em cães saudáveis. Porém, efeito cumulativo do tratamento com dorzolamida/timolol foi observado, decorridos três dias de tratamento. Por essa razão, a dorzolamida/timolol foi mais efetiva que a tafluprosta na redução da PIO. Comparações entre os tratamentos demonstraram que a tafluprosta foi mais efetiva em reduzir o DP, durante toda a fase de tratamento.]]></description><identifier>ISSN: 0103-8478</identifier><identifier>ISSN: 1678-4596</identifier><identifier>EISSN: 0103-8478</identifier><identifier>EISSN: 1678-4596</identifier><identifier>DOI: 10.1590/0103-8478cr20160959</identifier><language>eng ; por</language><publisher>Santa Maria: Universidade Federal de Santa Maria Centro de Ciencias Rurais</publisher><subject>AGRONOMY ; beta blocker ; carbonic anhydrase inhibitor ; Dogs ; Drugs ; Evaluation ; Glaucoma ; Intraocular pressure ; prostaglandin analogs ; Timolol</subject><ispartof>Ciência rural, 2017, Vol.47 (9)</ispartof><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/deed.en (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c377t-64dcfa4c143b5537b0344a22b9befc7c71fe5dd4f5234d2deb1085904496d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,862,883,4012,27910,27911,27912</link.rule.ids></links><search><creatorcontrib>Dower, Nathalie Moro Bassil</creatorcontrib><creatorcontrib>Ribeiro, Alexandre Pinto</creatorcontrib><creatorcontrib>Maciel, Camila do Espirito Santo</creatorcontrib><creatorcontrib>Spiller, Paulo Roberto</creatorcontrib><creatorcontrib>Monteiro, Geovanna Barreira</creatorcontrib><creatorcontrib>Pizzinatto, Fábio Dumit</creatorcontrib><creatorcontrib>Yamauchi, Kelly Cristiane Ito</creatorcontrib><title>Effects of dorzolamide/timolol and tafluprost on intraocular pressure and pupil diameter in healthy dogs</title><title>Ciência rural</title><addtitle>Cienc. Rural</addtitle><description><![CDATA[This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed at 8, 11, 14, 17, and 20h. Parameters were evaluated during baseline, treatment period of four days, and one day of post-treatment. During treatment phase, IOP decreased by 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), and 3.10mmHg (P<0.01), in dorzolamide/timolol-treated eyes; and by 1.50, 2.18, 2.14, and 2.18mmHg (P<0.001), in tafluprost-treated eyes. PD decreased by 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001), and 0.40mm (P<0.001), in dorzolamide/timolol treated eyes; and by 2.31, 2.55, 2.43, and 2.70mm (P<0.001), in tafluprost-treated eyes. Dorzolamide/timolol and tafluprost were able to decrease IOP and PD in healthy dogs. However, a cumulative effect of the fixed combination of dorzolamide/timolol was more effective in reducing IOP, than tafluprost. Comparisons between treatments showed that tafluprost was more effective in reducing PD throughout the treatment phase.
RESUMO: O estudo objetivou avaliar e comparar os efeitos da combinação fixa da dorzolamida/timolol com os da tafluprosta sobre a pressão intraocular (PIO) e o diâmetro pupilar (DP) em cães saudáveis (n=10). Dois experimentos com intervalo de 30 dias foram conduzidos. Em ambos, a PIO e o DP foram avaliados às 8, 11, 14, 17 e às 20h. Os parâmetros foram avaliados durante a fases basal, um período de tratamento de quatro dias, e um dia de pós-tratamento. Durante a fase de tratamento, a PIO dos olhos tratados com dorzolamida/timolol reduziram em 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), e 3.10mmHg (P<0.01); e dos olhos tratados com tafluprosta em 1.50, 2.18, 2.14 e 2.18mmHg (P<0.001). O DP dos olhos tratados com dorzolamida/timolol reduziram em 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001) e 0.40mm (P<0.001); e dos olhos tratados com tafluprosta em 2.31, 2.55, 2.43 e 2.70mm (P<0.001). A dorzolamida/timol e a tafluprosta foram capazes de reduzir a PIO e o DP em cães saudáveis. Porém, efeito cumulativo do tratamento com dorzolamida/timolol foi observado, decorridos três dias de tratamento. Por essa razão, a dorzolamida/timolol foi mais efetiva que a tafluprosta na redução da PIO. Comparações entre os tratamentos demonstraram que a tafluprosta foi mais efetiva em reduzir o DP, durante toda a fase de tratamento.]]></description><subject>AGRONOMY</subject><subject>beta blocker</subject><subject>carbonic anhydrase inhibitor</subject><subject>Dogs</subject><subject>Drugs</subject><subject>Evaluation</subject><subject>Glaucoma</subject><subject>Intraocular pressure</subject><subject>prostaglandin analogs</subject><subject>Timolol</subject><issn>0103-8478</issn><issn>1678-4596</issn><issn>0103-8478</issn><issn>1678-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNpNkUtLZDEQhS-i4PMXuAnMurXyuElnOYgzIwgudB_ytNOkO9ckd6G_3rQ9tK6qKM45HL4ahmsMN3iUcAsY6GLJxNIWApiDHOXRcHa4Hv_YT4fzWtcARFDGzobVfQjetopyQC6Xj5z0Jjp_2-Imp5yQ3jrUdEjzVHJtKG9R3Lais52TLmgqvta5-C_ZNE8xIRf1xjdfug6tvE5t9d6DX-vlcBJ0qv7q_7wYnv_cv9z9Wzw-_X24-_24sFSItuDM2aCZxYyacaTCQK-pCTHS-GCFFTj40TkWRkKZI84bDMuOgDHJnaQXw8M-1WW9VlOJG13eVdZRfR1yeVW6tGiTVxaCAcuN5Fwww7gxnBOLreFU8hBIz7rZZ1Ubfcpqneey7dXV8w6m2sHssAUASAAOtBt-7Q2d1dvsa_u2ECYJEYzTsavoXmU70Vp8ONTEoHbfVIf472_STwDrkXE</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Dower, Nathalie Moro Bassil</creator><creator>Ribeiro, Alexandre Pinto</creator><creator>Maciel, Camila do Espirito Santo</creator><creator>Spiller, Paulo Roberto</creator><creator>Monteiro, Geovanna Barreira</creator><creator>Pizzinatto, Fábio Dumit</creator><creator>Yamauchi, Kelly Cristiane Ito</creator><general>Universidade Federal de Santa Maria Centro de Ciencias Rurais</general><general>Universidade Federal de Santa Maria</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>M0K</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>2017</creationdate><title>Effects of dorzolamide/timolol and tafluprost on intraocular pressure and pupil diameter in healthy dogs</title><author>Dower, Nathalie Moro Bassil ; Ribeiro, Alexandre Pinto ; Maciel, Camila do Espirito Santo ; Spiller, Paulo Roberto ; Monteiro, Geovanna Barreira ; Pizzinatto, Fábio Dumit ; Yamauchi, Kelly Cristiane Ito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-64dcfa4c143b5537b0344a22b9befc7c71fe5dd4f5234d2deb1085904496d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2017</creationdate><topic>AGRONOMY</topic><topic>beta blocker</topic><topic>carbonic anhydrase inhibitor</topic><topic>Dogs</topic><topic>Drugs</topic><topic>Evaluation</topic><topic>Glaucoma</topic><topic>Intraocular pressure</topic><topic>prostaglandin analogs</topic><topic>Timolol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dower, Nathalie Moro Bassil</creatorcontrib><creatorcontrib>Ribeiro, Alexandre Pinto</creatorcontrib><creatorcontrib>Maciel, Camila do Espirito Santo</creatorcontrib><creatorcontrib>Spiller, Paulo Roberto</creatorcontrib><creatorcontrib>Monteiro, Geovanna Barreira</creatorcontrib><creatorcontrib>Pizzinatto, Fábio Dumit</creatorcontrib><creatorcontrib>Yamauchi, Kelly Cristiane Ito</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Agricultural Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Ciência rural</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dower, Nathalie Moro Bassil</au><au>Ribeiro, Alexandre Pinto</au><au>Maciel, Camila do Espirito Santo</au><au>Spiller, Paulo Roberto</au><au>Monteiro, Geovanna Barreira</au><au>Pizzinatto, Fábio Dumit</au><au>Yamauchi, Kelly Cristiane Ito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dorzolamide/timolol and tafluprost on intraocular pressure and pupil diameter in healthy dogs</atitle><jtitle>Ciência rural</jtitle><addtitle>Cienc. Rural</addtitle><date>2017</date><risdate>2017</risdate><volume>47</volume><issue>9</issue><issn>0103-8478</issn><issn>1678-4596</issn><eissn>0103-8478</eissn><eissn>1678-4596</eissn><abstract><![CDATA[This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed at 8, 11, 14, 17, and 20h. Parameters were evaluated during baseline, treatment period of four days, and one day of post-treatment. During treatment phase, IOP decreased by 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), and 3.10mmHg (P<0.01), in dorzolamide/timolol-treated eyes; and by 1.50, 2.18, 2.14, and 2.18mmHg (P<0.001), in tafluprost-treated eyes. PD decreased by 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001), and 0.40mm (P<0.001), in dorzolamide/timolol treated eyes; and by 2.31, 2.55, 2.43, and 2.70mm (P<0.001), in tafluprost-treated eyes. Dorzolamide/timolol and tafluprost were able to decrease IOP and PD in healthy dogs. However, a cumulative effect of the fixed combination of dorzolamide/timolol was more effective in reducing IOP, than tafluprost. Comparisons between treatments showed that tafluprost was more effective in reducing PD throughout the treatment phase.
RESUMO: O estudo objetivou avaliar e comparar os efeitos da combinação fixa da dorzolamida/timolol com os da tafluprosta sobre a pressão intraocular (PIO) e o diâmetro pupilar (DP) em cães saudáveis (n=10). Dois experimentos com intervalo de 30 dias foram conduzidos. Em ambos, a PIO e o DP foram avaliados às 8, 11, 14, 17 e às 20h. Os parâmetros foram avaliados durante a fases basal, um período de tratamento de quatro dias, e um dia de pós-tratamento. Durante a fase de tratamento, a PIO dos olhos tratados com dorzolamida/timolol reduziram em 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), e 3.10mmHg (P<0.01); e dos olhos tratados com tafluprosta em 1.50, 2.18, 2.14 e 2.18mmHg (P<0.001). O DP dos olhos tratados com dorzolamida/timolol reduziram em 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001) e 0.40mm (P<0.001); e dos olhos tratados com tafluprosta em 2.31, 2.55, 2.43 e 2.70mm (P<0.001). A dorzolamida/timol e a tafluprosta foram capazes de reduzir a PIO e o DP em cães saudáveis. Porém, efeito cumulativo do tratamento com dorzolamida/timolol foi observado, decorridos três dias de tratamento. Por essa razão, a dorzolamida/timolol foi mais efetiva que a tafluprosta na redução da PIO. Comparações entre os tratamentos demonstraram que a tafluprosta foi mais efetiva em reduzir o DP, durante toda a fase de tratamento.]]></abstract><cop>Santa Maria</cop><pub>Universidade Federal de Santa Maria Centro de Ciencias Rurais</pub><doi>10.1590/0103-8478cr20160959</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Ciência rural, 2017, Vol.47 (9) |
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| language | eng ; por |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | AGRONOMY beta blocker carbonic anhydrase inhibitor Dogs Drugs Evaluation Glaucoma Intraocular pressure prostaglandin analogs Timolol |
| title | Effects of dorzolamide/timolol and tafluprost on intraocular pressure and pupil diameter in healthy dogs |
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