Synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin
We describe herein a short and efficient synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin. Notable features of this approach include a Sharpless asymmetric epoxidation followed by epoxide opening under Myashita's conditions to introduce the stereogenic centers at C6 an...
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| Veröffentlicht in: | Journal of the Brazilian Chemical Society 2012-02, Vol.23 (2), p.344-348 |
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| container_end_page | 348 |
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| container_issue | 2 |
| container_start_page | 344 |
| container_title | Journal of the Brazilian Chemical Society |
| container_volume | 23 |
| creator | Dias, Luiz C. Sant'Ana, Danilo P. Vieira, Ygor W. Gonçalves, Caroline C. S. Lima, Dimas J. P. |
| description | We describe herein a short and efficient synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin. Notable features of this approach include a Sharpless asymmetric epoxidation followed by epoxide opening under Myashita's conditions to introduce the stereogenic centers at C6 and C7, and a Horner-Wadsworth-Emmons type reaction under Ando's conditions to construct the Z-double bond of the 1,3-(Z,E)-diene system. |
| doi_str_mv | 10.1590/S0103-50532012000200022 |
| format | Article |
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| ispartof | Journal of the Brazilian Chemical Society, 2012-02, Vol.23 (2), p.344-348 |
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| language | eng |
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| subjects | CHEMISTRY, MULTIDISCIPLINARY |
| title | Synthesis of the C1-C9 fragment of the potent antitumor agent dictyostatin |
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