Synthesis and enzymatic evaluation of the guanosine analogue 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG): insights into the phosphorolysis reaction mechanism based on the blueprint transition state: SN1 or S N2?

A modified experimental procedure for the synthesis of MESG (2-amino-6-mercapto-7-methylpurine ribonucleoside) 1 has been successfully performed and its full characterization is presented. High resolution ESI(+)-MSMS indicates both the nucleoside bond cleavage as the main fragmentation in the gas ph...

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Veröffentlicht in:	Journal of the Brazilian Chemical Society 2010, Vol.21 (1), p.151-156
Hauptverfasser:	Neto, Brenno A. D., Lapis, Alexandre A. M., Netz, Paulo A., Spencer, John, Dias, Silvio L. P., Tamborim, Silvia M., Basso, Luiz A., Santos, Diógenes S., Dupont, Jairton
Format:	Artikel
Sprache:	eng
Schlagworte:	CHEMISTRY, MULTIDISCIPLINARY
Online-Zugang:	Volltext
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