State-of-the-art in immobilized polymer stationary phases for high-performance liquid chromatography

State-of-the-art in immobilized polymer stationary phases for high-performance liquid chromatography

Increasing stability and reducing the high activity of residual groups from stationary phases have been the main focuses of research on the preparation of reversed-phase high-performance liquid chromatography (RP-HPLC) phases over the last four decades. New and more efficient strategies for modifyin...

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Veröffentlicht in:Journal of the Brazilian Chemical Society 2009, Vol.20 (8), p.1385-1398
Hauptverfasser: Faria, Anizio M., Collins, Carol H., Jardim, Isabel C. S. F.
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CHEMISTRY, MULTIDISCIPLINARY
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container_title Journal of the Brazilian Chemical Society
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creator Faria, Anizio M.
Collins, Carol H.
Jardim, Isabel C. S. F.
description Increasing stability and reducing the high activity of residual groups from stationary phases have been the main focuses of research on the preparation of reversed-phase high-performance liquid chromatography (RP-HPLC) phases over the last four decades. New and more efficient strategies for modifying the silica surface as well as the introduction of new chromatographic supports have minimized these effects and have enabled the increasing popularization of RP-HPLC. In this paper, an overview will be given of the state-of-the-art in stationary phases for RP-HPLC based on immobilization of pre-synthesized organic polymers on both silica and metalized-silica supports. Special consideration is given to the development of HPLC stationary phases in Brazil in the past 15 years.
doi_str_mv 10.1590/S0103-50532009000800002
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title State-of-the-art in immobilized polymer stationary phases for high-performance liquid chromatography
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