New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis

New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis

Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activi...

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Veröffentlicht in:Journal of the Brazilian Chemical Society 2005-11, Vol.16 (6b), p.1463-1466
Hauptverfasser: Silva, Geraldo H., Teles, Helder L., Trevisan, Henrique C., Bolzani, Vanderlan da S., Young, Maria C. M., Pfenning, Ludwig H., Eberlin, Marcos N., Haddad, Renato, Costa-Neto, Claudio M., Araújo, Ângela R.
Format: Artikel
Sprache:eng
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CHEMISTRY, MULTIDISCIPLINARY
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Zusammenfassung:Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays.
ISSN:0103-5053
1678-4790
DOI:10.1590/S0103-50532005000800029