Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae
Hydroalcoholic extract of the aero parts of the Herissantia tiubae (HtE). Hydroalcoholic extract of aerial parts of Herissantia tiubae (K. Schum.) Brizicky, Malvaceae, was evaluated in experimental models of inflammation and toxicity. For toxicity assays, male and female Swiss mice were orally treat...
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| Veröffentlicht in: | Revista brasileira de farmacognosia 2016-03, Vol.26 (2), p.225-232 |
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| creator | Lima, Ana L.A. Alves, Adriano F. Xavier, Aline L. Mozzini-Monteiro, Talissa Oliveira, Theresa R.R. Leite, Fagner C. Matias, Wemerson N. Branco, Marianna V.S.C. Souza, Maria F.V. Piuvezam, Marcia R. |
| description | Hydroalcoholic extract of the aero parts of the Herissantia tiubae (HtE).
Hydroalcoholic extract of aerial parts of Herissantia tiubae (K. Schum.) Brizicky, Malvaceae, was evaluated in experimental models of inflammation and toxicity. For toxicity assays, male and female Swiss mice were orally treated with hydroalcoholic extract of H. tiubae (2000mg/kg) and analyzed by consumption of water and food, body weight, mortality and rates of major organ weights, as well as biochemical and hematological indexes. For anti-inflammatory effect, phlogistic agents such as carrageenan or acetic acid were used to evaluate paw edema, cell migration and cytokine production. It was also investigated the hydroalcoholic extract of H. tiubae in RAW 264.7 macrophage lineage by nitric oxide and cytokine productions. Swiss mice treated with hydroalcoholic extract of H. tiubae showed low toxicity and (50 or 100mg/kg) was able to reduce significantly (p |
| doi_str_mv | 10.1016/j.bjp.2015.11.001 |
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Hydroalcoholic extract of aerial parts of Herissantia tiubae (K. Schum.) Brizicky, Malvaceae, was evaluated in experimental models of inflammation and toxicity. For toxicity assays, male and female Swiss mice were orally treated with hydroalcoholic extract of H. tiubae (2000mg/kg) and analyzed by consumption of water and food, body weight, mortality and rates of major organ weights, as well as biochemical and hematological indexes. For anti-inflammatory effect, phlogistic agents such as carrageenan or acetic acid were used to evaluate paw edema, cell migration and cytokine production. It was also investigated the hydroalcoholic extract of H. tiubae in RAW 264.7 macrophage lineage by nitric oxide and cytokine productions. Swiss mice treated with hydroalcoholic extract of H. tiubae showed low toxicity and (50 or 100mg/kg) was able to reduce significantly (p<0.01, p<0.001) polymorphonuclear cell migration, TNF-α and IL-1β production in the carrageenan-induced peritonitis. However the hydroalcoholic extract of H. tiubae (50, 100 or 200mg/kg) did not reduce carrageenan-induced paw edema. Additionally, hydroalcoholic extract of H. tiubae did not present cytotoxicity at concentrations of 6.25, 12.5, 25 or 50μg/ml but induced significantly decrease of NO, TNF-α and IL-6 production in macrophage lineage. This study suggests that hydroalcoholic extract of H. tiubae has anti-inflammatory activity by inhibiting cell migration mainly by decreasing the inflammatory cytokine levels at the inflamed site independently of the anti-edematogenic effect.</description><identifier>ISSN: 0102-695X</identifier><identifier>ISSN: 1981-528X</identifier><identifier>EISSN: 1981-528X</identifier><identifier>DOI: 10.1016/j.bjp.2015.11.001</identifier><language>eng</language><publisher>Cham: Elsevier Editora Ltda</publisher><subject>Acute inflammation ; Acute toxicity ; Anti-inflammatory activity ; Herrisantia tiubae ; Malvaceae ; Mice ; Original Artide ; PHARMACOLOGY & PHARMACY ; Pharmacy</subject><ispartof>Revista brasileira de farmacognosia, 2016-03, Vol.26 (2), p.225-232</ispartof><rights>2015 Sociedade Brasileira de Farmacognosia</rights><rights>Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved. 2015</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-7444508c9a41e9a6c008c8fc331e3e894b52ea3a2f158500e6f3b6f750d20b783</citedby><cites>FETCH-LOGICAL-c422t-7444508c9a41e9a6c008c8fc331e3e894b52ea3a2f158500e6f3b6f750d20b783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1016/j.bjp.2015.11.001$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1016/j.bjp.2015.11.001$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Lima, Ana L.A.</creatorcontrib><creatorcontrib>Alves, Adriano F.</creatorcontrib><creatorcontrib>Xavier, Aline L.</creatorcontrib><creatorcontrib>Mozzini-Monteiro, Talissa</creatorcontrib><creatorcontrib>Oliveira, Theresa R.R.</creatorcontrib><creatorcontrib>Leite, Fagner C.</creatorcontrib><creatorcontrib>Matias, Wemerson N.</creatorcontrib><creatorcontrib>Branco, Marianna V.S.C.</creatorcontrib><creatorcontrib>Souza, Maria F.V.</creatorcontrib><creatorcontrib>Piuvezam, Marcia R.</creatorcontrib><title>Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae</title><title>Revista brasileira de farmacognosia</title><addtitle>Revista Brasileira de Farmacognosia</addtitle><addtitle>Rev. bras. farmacogn</addtitle><description>Hydroalcoholic extract of the aero parts of the Herissantia tiubae (HtE).
Hydroalcoholic extract of aerial parts of Herissantia tiubae (K. Schum.) Brizicky, Malvaceae, was evaluated in experimental models of inflammation and toxicity. For toxicity assays, male and female Swiss mice were orally treated with hydroalcoholic extract of H. tiubae (2000mg/kg) and analyzed by consumption of water and food, body weight, mortality and rates of major organ weights, as well as biochemical and hematological indexes. For anti-inflammatory effect, phlogistic agents such as carrageenan or acetic acid were used to evaluate paw edema, cell migration and cytokine production. It was also investigated the hydroalcoholic extract of H. tiubae in RAW 264.7 macrophage lineage by nitric oxide and cytokine productions. Swiss mice treated with hydroalcoholic extract of H. tiubae showed low toxicity and (50 or 100mg/kg) was able to reduce significantly (p<0.01, p<0.001) polymorphonuclear cell migration, TNF-α and IL-1β production in the carrageenan-induced peritonitis. However the hydroalcoholic extract of H. tiubae (50, 100 or 200mg/kg) did not reduce carrageenan-induced paw edema. Additionally, hydroalcoholic extract of H. tiubae did not present cytotoxicity at concentrations of 6.25, 12.5, 25 or 50μg/ml but induced significantly decrease of NO, TNF-α and IL-6 production in macrophage lineage. This study suggests that hydroalcoholic extract of H. tiubae has anti-inflammatory activity by inhibiting cell migration mainly by decreasing the inflammatory cytokine levels at the inflamed site independently of the anti-edematogenic effect.</description><subject>Acute inflammation</subject><subject>Acute toxicity</subject><subject>Anti-inflammatory activity</subject><subject>Herrisantia tiubae</subject><subject>Malvaceae</subject><subject>Mice</subject><subject>Original Artide</subject><subject>PHARMACOLOGY & PHARMACY</subject><subject>Pharmacy</subject><issn>0102-695X</issn><issn>1981-528X</issn><issn>1981-528X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kN1KxDAQhYMouP48gHd9gdaZtOmmeCWiriB4ocLehTSduindRpKsuG9vygreCYFkknxz5hzGrhAKBKyvh6IdPgsOKArEAgCP2AIbibngcn3MFoDA87oR61N2FsIAIGrJ5YLR7RRtbqd-1Nutjs7vM22i_bIxHaYuFbtIWXTf1sxXIe46SyFzfbbZd97p0biNG63J6Dv6RM4vK_I2BJ0a6yzaXavpgp30egx0-bufs_eH-7e7Vf788vh0d_ucm4rzmC-rqhIgTaMrpEbXBlIhe1OWSCXJpmoFJ11q3qOQAoDqvmzrfimg49AuZXnOikPfYCyNTg1u56ckqF5n_2r2nyKqAYCnxUUC8AAY70Lw1KtPb7fa7xWCmoNVg0rBqjlYhahSsInhvyLp7_RB_k_mP-jmAFGy_2UTNI84GeqsJxNV5-w_9A8L25Cs</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Lima, Ana L.A.</creator><creator>Alves, Adriano F.</creator><creator>Xavier, Aline L.</creator><creator>Mozzini-Monteiro, Talissa</creator><creator>Oliveira, Theresa R.R.</creator><creator>Leite, Fagner C.</creator><creator>Matias, Wemerson N.</creator><creator>Branco, Marianna V.S.C.</creator><creator>Souza, Maria F.V.</creator><creator>Piuvezam, Marcia R.</creator><general>Elsevier Editora Ltda</general><general>Springer International Publishing</general><general>Sociedade Brasileira de Farmacognosia</general><scope>6I.</scope><scope>AAFTH</scope><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope></search><sort><creationdate>20160301</creationdate><title>Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae</title><author>Lima, Ana L.A. ; Alves, Adriano F. ; Xavier, Aline L. ; Mozzini-Monteiro, Talissa ; Oliveira, Theresa R.R. ; Leite, Fagner C. ; Matias, Wemerson N. ; Branco, Marianna V.S.C. ; Souza, Maria F.V. ; Piuvezam, Marcia R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-7444508c9a41e9a6c008c8fc331e3e894b52ea3a2f158500e6f3b6f750d20b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute inflammation</topic><topic>Acute toxicity</topic><topic>Anti-inflammatory activity</topic><topic>Herrisantia tiubae</topic><topic>Malvaceae</topic><topic>Mice</topic><topic>Original Artide</topic><topic>PHARMACOLOGY & PHARMACY</topic><topic>Pharmacy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Ana L.A.</creatorcontrib><creatorcontrib>Alves, Adriano F.</creatorcontrib><creatorcontrib>Xavier, Aline L.</creatorcontrib><creatorcontrib>Mozzini-Monteiro, Talissa</creatorcontrib><creatorcontrib>Oliveira, Theresa R.R.</creatorcontrib><creatorcontrib>Leite, Fagner C.</creatorcontrib><creatorcontrib>Matias, Wemerson N.</creatorcontrib><creatorcontrib>Branco, Marianna V.S.C.</creatorcontrib><creatorcontrib>Souza, Maria F.V.</creatorcontrib><creatorcontrib>Piuvezam, Marcia R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>SciELO</collection><jtitle>Revista brasileira de farmacognosia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Ana L.A.</au><au>Alves, Adriano F.</au><au>Xavier, Aline L.</au><au>Mozzini-Monteiro, Talissa</au><au>Oliveira, Theresa R.R.</au><au>Leite, Fagner C.</au><au>Matias, Wemerson N.</au><au>Branco, Marianna V.S.C.</au><au>Souza, Maria F.V.</au><au>Piuvezam, Marcia R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae</atitle><jtitle>Revista brasileira de farmacognosia</jtitle><stitle>Revista Brasileira de Farmacognosia</stitle><addtitle>Rev. bras. farmacogn</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>26</volume><issue>2</issue><spage>225</spage><epage>232</epage><pages>225-232</pages><issn>0102-695X</issn><issn>1981-528X</issn><eissn>1981-528X</eissn><abstract>Hydroalcoholic extract of the aero parts of the Herissantia tiubae (HtE).
Hydroalcoholic extract of aerial parts of Herissantia tiubae (K. Schum.) Brizicky, Malvaceae, was evaluated in experimental models of inflammation and toxicity. For toxicity assays, male and female Swiss mice were orally treated with hydroalcoholic extract of H. tiubae (2000mg/kg) and analyzed by consumption of water and food, body weight, mortality and rates of major organ weights, as well as biochemical and hematological indexes. For anti-inflammatory effect, phlogistic agents such as carrageenan or acetic acid were used to evaluate paw edema, cell migration and cytokine production. It was also investigated the hydroalcoholic extract of H. tiubae in RAW 264.7 macrophage lineage by nitric oxide and cytokine productions. Swiss mice treated with hydroalcoholic extract of H. tiubae showed low toxicity and (50 or 100mg/kg) was able to reduce significantly (p<0.01, p<0.001) polymorphonuclear cell migration, TNF-α and IL-1β production in the carrageenan-induced peritonitis. However the hydroalcoholic extract of H. tiubae (50, 100 or 200mg/kg) did not reduce carrageenan-induced paw edema. Additionally, hydroalcoholic extract of H. tiubae did not present cytotoxicity at concentrations of 6.25, 12.5, 25 or 50μg/ml but induced significantly decrease of NO, TNF-α and IL-6 production in macrophage lineage. This study suggests that hydroalcoholic extract of H. tiubae has anti-inflammatory activity by inhibiting cell migration mainly by decreasing the inflammatory cytokine levels at the inflamed site independently of the anti-edematogenic effect.</abstract><cop>Cham</cop><pub>Elsevier Editora Ltda</pub><doi>10.1016/j.bjp.2015.11.001</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute inflammation Acute toxicity Anti-inflammatory activity Herrisantia tiubae Malvaceae Mice Original Artide PHARMACOLOGY & PHARMACY Pharmacy |
| title | Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae |
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