Antimutagenic bis (2-ethylhexyl) phthalate isolated from octopus (Paraoctopus vulgaris)

Antimutagenic bis (2-ethylhexyl) phthalate isolated from octopus (Paraoctopus vulgaris)

Abstract In the present study, the antimutagenic activity of methanolic (MP) and hexanic (HP) phase from hexane-soluble extract of Paraoctopus vulgaris was evaluated. The HP showed significant concentration-dependent antimutagenic activity (p < 0.05) in the Ames assay against aflatoxin B1 (AFB1)...

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Veröffentlicht in:Ciência e tecnologia de alimentos 2021-04, Vol.41 (2), p.314-320
Hauptverfasser: CRUZ-RAMÍREZ, Susana-Gabriela, LÓPEZ-SAIZ, Carmen-María, ROSAS-BURGOS, Ema-Carina, CINCO-MOROYOQUI, Francisco-Javier, VELÁZQUEZ, Carlos, HERNÁNDEZ, Javier, BURGOS-HERNÁNDEZ, Armando
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creator CRUZ-RAMÍREZ, Susana-Gabriela
LÓPEZ-SAIZ, Carmen-María
ROSAS-BURGOS, Ema-Carina
CINCO-MOROYOQUI, Francisco-Javier
VELÁZQUEZ, Carlos
HERNÁNDEZ, Javier
BURGOS-HERNÁNDEZ, Armando
description Abstract In the present study, the antimutagenic activity of methanolic (MP) and hexanic (HP) phase from hexane-soluble extract of Paraoctopus vulgaris was evaluated. The HP showed significant concentration-dependent antimutagenic activity (p < 0.05) in the Ames assay against aflatoxin B1 (AFB1) using Salmonella typhimurium TA98 and TA100 tester strains. Seven fractions (F1-F7) were obtained from HP by silica gel-column chromatography and the antimutagenic activity of F6 and F7 caused significant reduction (p < 0.05) in the number of AFB1-induced revertants in both strains. However, high antimutagenic activity was exhibited in TA98 strain (85-97% reversion inhibition) and remained at a fraction-concentration of 3 μg/mL. F6 and F7 composition was analyzed by high-performance liquid chromatography/photodiode array, both fractions shared one peak at 9.42 min suggesting presence of the same compound. 1H-NMR and 13C-NMR analysis results indicate that the bioactive compound is bis (2-ethylhexyl) phthalate. Based on of these results bis (2-ethylhexyl) phthalate exhibit antimutagenic activity, which allows to consider it for further investigation as a potential chemopreventive compound.
doi_str_mv 10.1590/fst.26119
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title Antimutagenic bis (2-ethylhexyl) phthalate isolated from octopus (Paraoctopus vulgaris)
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