Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells

Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells

Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fraction...

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Veröffentlicht in:Ciência e tecnologia de alimentos 2019-12, Vol.39 (4), p.947-954
Hauptverfasser: LEE, Sang Hyun, LEE, Hyesook, KIM, Jae Cherl
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FOOD SCIENCE & TECHNOLOGY
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LEE, Hyesook
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description Abstract The effect of water extracts of doenjang (WED) on cyclooxygenase pathway and cytokine production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells was investigated. WED was fractionated by ultrafiltration into five individual groups of molecular weights. All of the WED fractions significantly inhibited the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Furthermore, each of the WED fractions significantly decreased production of pro-inflammatory cytokine such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) (p
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title Anti-inflammatory effect of water extracts obtained from doenjang in LPS-stimulated RAW 264.7 cells
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