Anal High-risk HPV and Liquid-based Cytology of Immunocompetent Brazilian Women with Genital High-risk HPV
The purpose of this study was to compare the frequency of the occurrence of high-risk human papillomavirus (HPV) and abnormal anal cytology in immunocompetent women with and without HPV-induced genital lesions. This analytical cross-sectional, observational study was conducted between July 2017 and...
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| Veröffentlicht in: | Revista Brasileira de ginecologia e obstetrícia 2022-03, Vol.44 (3), p.280-286 |
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| creator | Melo, Karla Maria Rêgo Leopoldo Eleutério Junior, José Peixoto, Raquel Autran Coelho Rebouças, Karinne Cisne Fernandes Eleutério, Renata Mirian Nunes |
| description | The purpose of this study was to compare the frequency of the occurrence of high-risk human papillomavirus (HPV) and abnormal anal cytology in immunocompetent women with and without HPV-induced genital lesions.
This analytical cross-sectional, observational study was conducted between July 2017 and December 2018 in a specialized outpatient clinic of a tertiary hospital in Fortaleza, CE. Fifty-seven immunocompetent women with and without genital intraepithelial lesions were assessed; they were divided into two groups: group 1 was comprised of women with HPV-associated genital lesions (
= 26), and group 2 was comprised of those without HPV-associated genital lesions (
= 31). Samples for liquid-based cytology and high-risk DNA-HPV polymerase chain reaction real-time tests were collected from the cervix and anus. All cases were evaluated using high-resolution anoscopy; biopsies were performed when required. The Fisher exact and chi-squared tests were applied for consolidated data in the contingency table, and the Student
-test and Mann-Whitney U-test for independent variables.
Anal high-risk HPV infections were more frequent in group 1 (odds ratio [OR], 4.95; 95% confidence interval [CI], 1.34-18.3;
= 0.012), along with concomitant high-risk HPV infections in the uterine cervix and the anus (OR 18.8; 95% CI, 2.20-160;
|
| doi_str_mv | 10.1055/s-0042-1742405 |
| format | Article |
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This analytical cross-sectional, observational study was conducted between July 2017 and December 2018 in a specialized outpatient clinic of a tertiary hospital in Fortaleza, CE. Fifty-seven immunocompetent women with and without genital intraepithelial lesions were assessed; they were divided into two groups: group 1 was comprised of women with HPV-associated genital lesions (
= 26), and group 2 was comprised of those without HPV-associated genital lesions (
= 31). Samples for liquid-based cytology and high-risk DNA-HPV polymerase chain reaction real-time tests were collected from the cervix and anus. All cases were evaluated using high-resolution anoscopy; biopsies were performed when required. The Fisher exact and chi-squared tests were applied for consolidated data in the contingency table, and the Student
-test and Mann-Whitney U-test for independent variables.
Anal high-risk HPV infections were more frequent in group 1 (odds ratio [OR], 4.95; 95% confidence interval [CI], 1.34-18.3;
= 0.012), along with concomitant high-risk HPV infections in the uterine cervix and the anus (OR 18.8; 95% CI, 2.20-160;
< 0.001). The incidence of high-risk cervical HPV infection was associated with high-risk anal HPV infection (OR, 4.95; 95% CI, 1.34-18.3;
= 0.012). There was no statistical difference concerning abnormal anal cytology or anoscopy between the groups, and no anal intraepithelial lesion was found in either group.
Immunocompetent women with HPV-associated genital lesions and high-risk cervical HPV were more likely to have high-risk anal HPV.</description><identifier>ISSN: 0100-7203</identifier><identifier>ISSN: 1806-9339</identifier><identifier>EISSN: 1806-9339</identifier><identifier>DOI: 10.1055/s-0042-1742405</identifier><identifier>PMID: 35139570</identifier><language>eng</language><publisher>Brazil: Thieme Revinter Publicações Ltda</publisher><subject>Anal Canal ; Anus Diseases - complications ; Anus Diseases - epidemiology ; Brazil - epidemiology ; Cervix Uteri - pathology ; Cross-Sectional Studies ; Female ; Humans ; OBSTETRICS & GYNECOLOGY ; Original ; Papillomaviridae ; Papillomavirus Infections - complications ; Papillomavirus Infections - diagnosis ; Papillomavirus Infections - epidemiology</subject><ispartof>Revista Brasileira de ginecologia e obstetrícia, 2022-03, Vol.44 (3), p.280-286</ispartof><rights>Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).</rights><rights>Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( ) 2022 Federação Brasileira de Ginecologia e Obstetrícia.</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-c4aee751755fd1235d81752fefda442cbd90c310d7eb6d63a35a1c61f0ae3a973</citedby><cites>FETCH-LOGICAL-c429t-c4aee751755fd1235d81752fefda442cbd90c310d7eb6d63a35a1c61f0ae3a973</cites><orcidid>0000-0002-2998-2779 ; 0000-0003-1754-2060 ; 0000-0003-4617-7269 ; 0000-0002-0548-4097 ; 0000-0002-6806-3804</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948116/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948116/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35139570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melo, Karla Maria Rêgo Leopoldo</creatorcontrib><creatorcontrib>Eleutério Junior, José</creatorcontrib><creatorcontrib>Peixoto, Raquel Autran Coelho</creatorcontrib><creatorcontrib>Rebouças, Karinne Cisne Fernandes</creatorcontrib><creatorcontrib>Eleutério, Renata Mirian Nunes</creatorcontrib><title>Anal High-risk HPV and Liquid-based Cytology of Immunocompetent Brazilian Women with Genital High-risk HPV</title><title>Revista Brasileira de ginecologia e obstetrícia</title><addtitle>Rev Bras Ginecol Obstet</addtitle><description>The purpose of this study was to compare the frequency of the occurrence of high-risk human papillomavirus (HPV) and abnormal anal cytology in immunocompetent women with and without HPV-induced genital lesions.
This analytical cross-sectional, observational study was conducted between July 2017 and December 2018 in a specialized outpatient clinic of a tertiary hospital in Fortaleza, CE. Fifty-seven immunocompetent women with and without genital intraepithelial lesions were assessed; they were divided into two groups: group 1 was comprised of women with HPV-associated genital lesions (
= 26), and group 2 was comprised of those without HPV-associated genital lesions (
= 31). Samples for liquid-based cytology and high-risk DNA-HPV polymerase chain reaction real-time tests were collected from the cervix and anus. All cases were evaluated using high-resolution anoscopy; biopsies were performed when required. The Fisher exact and chi-squared tests were applied for consolidated data in the contingency table, and the Student
-test and Mann-Whitney U-test for independent variables.
Anal high-risk HPV infections were more frequent in group 1 (odds ratio [OR], 4.95; 95% confidence interval [CI], 1.34-18.3;
= 0.012), along with concomitant high-risk HPV infections in the uterine cervix and the anus (OR 18.8; 95% CI, 2.20-160;
< 0.001). The incidence of high-risk cervical HPV infection was associated with high-risk anal HPV infection (OR, 4.95; 95% CI, 1.34-18.3;
= 0.012). There was no statistical difference concerning abnormal anal cytology or anoscopy between the groups, and no anal intraepithelial lesion was found in either group.
Immunocompetent women with HPV-associated genital lesions and high-risk cervical HPV were more likely to have high-risk anal HPV.</description><subject>Anal Canal</subject><subject>Anus Diseases - complications</subject><subject>Anus Diseases - epidemiology</subject><subject>Brazil - epidemiology</subject><subject>Cervix Uteri - pathology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>OBSTETRICS & GYNECOLOGY</subject><subject>Original</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Papillomavirus Infections - epidemiology</subject><issn>0100-7203</issn><issn>1806-9339</issn><issn>1806-9339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUU1PGzEQtVCrEmivHCsfe1kYf613L0gQtQQpEpWgcLQc25s43bWDvdsq_Ho2IiDay8xIM-_NzHsInRA4JSDEWS4AOC2I5JSDOEATUkFZ1IzVH9AECEAhKbBDdJTzGoBKVvFP6JAJwmohYYLWF0G3eOaXqyL5_BvPft5jHSye-8fB22Khs7N4uu1jG5dbHBt83XVDiCZ2G9e70OPLpJ9863XAD7FzAf_1_QpfueD7_3k_o4-NbrP7ss_H6NeP73fTWTG_ubqeXswLw2ndj1E7JwWRQjSWUCZsNda0cY3VnFOzsDUYRsBKtyhtyTQTmpiSNKAd07Vkx-j0hTcb79qo1nFI45NZ3e70UDs9KFAKAGxUpIIRcP4C2AyLzlkzvpV0qzbJdzptVdRe_dsJfqWW8Y-qa14RUo4E3_YEKT4OLveq89m4ttXBxSErWlLJpeTlu-NMijkn17ytIaB2jqqsdo6qvaMj4Ov7497GXy1kz2cTmlI</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Melo, Karla Maria Rêgo Leopoldo</creator><creator>Eleutério Junior, José</creator><creator>Peixoto, Raquel Autran Coelho</creator><creator>Rebouças, Karinne Cisne Fernandes</creator><creator>Eleutério, Renata Mirian Nunes</creator><general>Thieme Revinter Publicações Ltda</general><general>Federação Brasileira das Sociedades de Ginecologia e Obstetrícia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>GPN</scope><orcidid>https://orcid.org/0000-0002-2998-2779</orcidid><orcidid>https://orcid.org/0000-0003-1754-2060</orcidid><orcidid>https://orcid.org/0000-0003-4617-7269</orcidid><orcidid>https://orcid.org/0000-0002-0548-4097</orcidid><orcidid>https://orcid.org/0000-0002-6806-3804</orcidid></search><sort><creationdate>20220301</creationdate><title>Anal High-risk HPV and Liquid-based Cytology of Immunocompetent Brazilian Women with Genital High-risk HPV</title><author>Melo, Karla Maria Rêgo Leopoldo ; Eleutério Junior, José ; Peixoto, Raquel Autran Coelho ; Rebouças, Karinne Cisne Fernandes ; Eleutério, Renata Mirian Nunes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-c4aee751755fd1235d81752fefda442cbd90c310d7eb6d63a35a1c61f0ae3a973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anal Canal</topic><topic>Anus Diseases - complications</topic><topic>Anus Diseases - epidemiology</topic><topic>Brazil - epidemiology</topic><topic>Cervix Uteri - pathology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>OBSTETRICS & GYNECOLOGY</topic><topic>Original</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - diagnosis</topic><topic>Papillomavirus Infections - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melo, Karla Maria Rêgo Leopoldo</creatorcontrib><creatorcontrib>Eleutério Junior, José</creatorcontrib><creatorcontrib>Peixoto, Raquel Autran Coelho</creatorcontrib><creatorcontrib>Rebouças, Karinne Cisne Fernandes</creatorcontrib><creatorcontrib>Eleutério, Renata Mirian Nunes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SciELO</collection><jtitle>Revista Brasileira de ginecologia e obstetrícia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melo, Karla Maria Rêgo Leopoldo</au><au>Eleutério Junior, José</au><au>Peixoto, Raquel Autran Coelho</au><au>Rebouças, Karinne Cisne Fernandes</au><au>Eleutério, Renata Mirian Nunes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anal High-risk HPV and Liquid-based Cytology of Immunocompetent Brazilian Women with Genital High-risk HPV</atitle><jtitle>Revista Brasileira de ginecologia e obstetrícia</jtitle><addtitle>Rev Bras Ginecol Obstet</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>44</volume><issue>3</issue><spage>280</spage><epage>286</epage><pages>280-286</pages><issn>0100-7203</issn><issn>1806-9339</issn><eissn>1806-9339</eissn><abstract>The purpose of this study was to compare the frequency of the occurrence of high-risk human papillomavirus (HPV) and abnormal anal cytology in immunocompetent women with and without HPV-induced genital lesions.
This analytical cross-sectional, observational study was conducted between July 2017 and December 2018 in a specialized outpatient clinic of a tertiary hospital in Fortaleza, CE. Fifty-seven immunocompetent women with and without genital intraepithelial lesions were assessed; they were divided into two groups: group 1 was comprised of women with HPV-associated genital lesions (
= 26), and group 2 was comprised of those without HPV-associated genital lesions (
= 31). Samples for liquid-based cytology and high-risk DNA-HPV polymerase chain reaction real-time tests were collected from the cervix and anus. All cases were evaluated using high-resolution anoscopy; biopsies were performed when required. The Fisher exact and chi-squared tests were applied for consolidated data in the contingency table, and the Student
-test and Mann-Whitney U-test for independent variables.
Anal high-risk HPV infections were more frequent in group 1 (odds ratio [OR], 4.95; 95% confidence interval [CI], 1.34-18.3;
= 0.012), along with concomitant high-risk HPV infections in the uterine cervix and the anus (OR 18.8; 95% CI, 2.20-160;
< 0.001). The incidence of high-risk cervical HPV infection was associated with high-risk anal HPV infection (OR, 4.95; 95% CI, 1.34-18.3;
= 0.012). There was no statistical difference concerning abnormal anal cytology or anoscopy between the groups, and no anal intraepithelial lesion was found in either group.
Immunocompetent women with HPV-associated genital lesions and high-risk cervical HPV were more likely to have high-risk anal HPV.</abstract><cop>Brazil</cop><pub>Thieme Revinter Publicações Ltda</pub><pmid>35139570</pmid><doi>10.1055/s-0042-1742405</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2998-2779</orcidid><orcidid>https://orcid.org/0000-0003-1754-2060</orcidid><orcidid>https://orcid.org/0000-0003-4617-7269</orcidid><orcidid>https://orcid.org/0000-0002-0548-4097</orcidid><orcidid>https://orcid.org/0000-0002-6806-3804</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Thieme Connect Journals Open Access; PubMed Central |
| subjects | Anal Canal Anus Diseases - complications Anus Diseases - epidemiology Brazil - epidemiology Cervix Uteri - pathology Cross-Sectional Studies Female Humans OBSTETRICS & GYNECOLOGY Original Papillomaviridae Papillomavirus Infections - complications Papillomavirus Infections - diagnosis Papillomavirus Infections - epidemiology |
| title | Anal High-risk HPV and Liquid-based Cytology of Immunocompetent Brazilian Women with Genital High-risk HPV |
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