Improving in vitro screening compounds anti-Trypanosoma cruzi by GFP-expressing parasites

Conventional microscopic counting is a widely utilised method for evaluating the trypanocidal effects of drugs on intracellular amastigotes. This is a low-cost approach, but it is time-consuming and reliant on the expertise of the microscopist. So, there is a pressing need for developing technologie...

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Veröffentlicht in:	Memórias do Instituto Oswaldo Cruz 2024-01, Vol.119, p.e230223-e230223
Hauptverfasser:	Delvoss, Cleyson Mathias Morais, Inoue, Alexandre Haruo, da Silva, Rosiane Valeriano, Fragoso, Stênio Perdigão, Eger, Iriane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Drug Evaluation, Preclinical Green Fluorescent Proteins - genetics Inhibitory Concentration 50 Nitroimidazoles - pharmacology Parasitic Sensitivity Tests PARASITOLOGY TROPICAL MEDICINE Trypanocidal Agents - pharmacology Trypanosoma cruzi - drug effects Trypanosoma cruzi - genetics
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