The translational challenge in Chagas disease drug development

The translational challenge in Chagas disease drug development

Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampere...

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Veröffentlicht in:Memórias do Instituto Oswaldo Cruz 2022-01, Vol.117, p.e200501-e200501
Hauptverfasser: Kratz, Jadel M, Gonçalves, Karolina R, Romera, Lavínia Md, Moraes, Carolina Borsoi, Bittencourt-Cunha, Paula, Schenkman, Sergio, Chatelain, Eric, Sosa-Estani, Sergio
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TROPICAL MEDICINE
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container_title Memórias do Instituto Oswaldo Cruz
container_volume 117
creator Kratz, Jadel M
Gonçalves, Karolina R
Romera, Lavínia Md
Moraes, Carolina Borsoi
Bittencourt-Cunha, Paula
Schenkman, Sergio
Chatelain, Eric
Sosa-Estani, Sergio
description Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.
doi_str_mv 10.1590/0074-02760200501
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subjects PARASITOLOGY
Review
TROPICAL MEDICINE
title The translational challenge in Chagas disease drug development
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