Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M. tuberculosis knockout strain for cdd gene was obtained by allelic replacement. Evaluatio...

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Veröffentlicht in:	Memórias do Instituto Oswaldo Cruz 2017-11, Vol.112 (11), p.785-789
Hauptverfasser:	Villela, Anne Drumond, Rodrigues-Junior, Valnês S, Pinto, Antônio Frederico Michel, Falcão, Virgínia Carla de Almeida, Sánchez-Quitian, Zilpa Adriana, Eichler, Paula, Bizarro, Cristiano Valim, Basso, Luiz Augusto, Santos, Diógenes Santiago
Format:	Artikel
Sprache:	eng
Schlagworte:	cdd gene cytidine deaminase Cytidine Deaminase - biosynthesis Cytidine Deaminase - genetics Deoxycytidine - biosynthesis Deoxycytidine - genetics Gene Knockout Techniques Humans Macrophages - microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - pathogenicity PARASITOLOGY Short Communication Time Factors TROPICAL MEDICINE
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