The Stabilizing Effects of the Acquired Immunity on the Schistosomiasis Transmission Modeling - The Sensitivity Analysis
A mathematical model is proposed to analyze the effects of acquired immunity on the transmission of schistosomiasis in the human host. From this model the prevalence curve dependent on four parameters can be obtained. These parameters were estimated fitting the data by the maximum likelihood method....
Gespeichert in:
| Veröffentlicht in: | Memórias do Instituto Oswaldo Cruz 1998-01, Vol.93 (suppl 1), p.63-73 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 73 |
|---|---|
| container_issue | suppl 1 |
| container_start_page | 63 |
| container_title | Memórias do Instituto Oswaldo Cruz |
| container_volume | 93 |
| creator | Yang, H M Yang, A C |
| description | A mathematical model is proposed to analyze the effects of acquired
immunity on the transmission of schistosomiasis in the human host. From
this model the prevalence curve dependent on four parameters can be
obtained. These parameters were estimated fitting the data by the
maximum likelihood method. The model showed a good retrieving capacity
of real data from two endemic areas of schistosomiasis: Touros, Brazil
(Schistosoma mansoni) and Misungwi, Tanzania (S. haematobium). Also,
the average worm burden per person and the dispersion of parasite per
person in the community can be obtained from the model. In this paper,
the stabilizing effects of the acquired immunity assumption in the
model are assessed in terms of the epidemiological variables as
follows. Regarded to the prevalence curve, we calculate the confidence
interval, and related to the average worm burden and the worm
dispersion in the community, the sensitivity analysis (the range of the
variation) of both variables with respect to their parameters is
performed. |
| doi_str_mv | 10.1590/s0074-02761998000700009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_sciel</sourceid><recordid>TN_cdi_scielo_journals_S0074_02761998000700009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S0074_02761998000700009</scielo_id><sourcerecordid>69148740</sourcerecordid><originalsourceid>FETCH-LOGICAL-b435t-1131c2c9b6f152ba2bdbb69544c023786812f3dc65106e9156f63711d879ec463</originalsourceid><addsrcrecordid>eNp9UU1v3CAQRVWrdJP2J1TxqTcnDGBsjqsoX1KiHnZ7RoBxQ2SbhLGrbH992exmc6hUCYRm5r03wxtCToGeQaXoOVJai5KyWoJSDc1RvlR9IItD4SNZgKybsqGSfibHiI80p7kUR-RIKQacVQvysn7wxWoyNvThTxh_FZdd592EReyKKZeW7nkOybfF7TDMY5g2RRxfCyv3EHCKGIdgMGCxTmbEISCGDLiPre-3amXxqu9HDFP4vaUvR9NvMuEL-dSZHv3X_XtCfl5dri9uyrsf17cXy7vSCl5NJQAHx5yysoOKWcNsa61UlRCOMl43sgHW8dbJCqj0CirZSV4DtE2tvBOSn5CznS664PuoH-Oc8gioV1uj9D8OZsL3HeEpxefZ46Tzr5zvezP6OKOWCkRTC5qB9Q7oUkRMvtNPKQwmbTRQvV3Sf1p827eY7eDbA2-_lfeZbYjZRn8AuBSMfktGl49qQDD-F3vRm_U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69148740</pqid></control><display><type>article</type><title>The Stabilizing Effects of the Acquired Immunity on the Schistosomiasis Transmission Modeling - The Sensitivity Analysis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Bioline International</source><creator>Yang, H M ; Yang, A C</creator><creatorcontrib>Yang, H M ; Yang, A C</creatorcontrib><description>A mathematical model is proposed to analyze the effects of acquired
immunity on the transmission of schistosomiasis in the human host. From
this model the prevalence curve dependent on four parameters can be
obtained. These parameters were estimated fitting the data by the
maximum likelihood method. The model showed a good retrieving capacity
of real data from two endemic areas of schistosomiasis: Touros, Brazil
(Schistosoma mansoni) and Misungwi, Tanzania (S. haematobium). Also,
the average worm burden per person and the dispersion of parasite per
person in the community can be obtained from the model. In this paper,
the stabilizing effects of the acquired immunity assumption in the
model are assessed in terms of the epidemiological variables as
follows. Regarded to the prevalence curve, we calculate the confidence
interval, and related to the average worm burden and the worm
dispersion in the community, the sensitivity analysis (the range of the
variation) of both variables with respect to their parameters is
performed.</description><identifier>ISSN: 1678-8060</identifier><identifier>ISSN: 0074-0276</identifier><identifier>EISSN: 0074-0276</identifier><identifier>DOI: 10.1590/s0074-02761998000700009</identifier><identifier>PMID: 9921325</identifier><language>eng</language><publisher>Brazil: Fundação Oswaldo Cruz, Fiocruz</publisher><subject>Animals ; Confidence Intervals ; Host-Parasite Interactions - immunology ; Humans ; Models, Immunological ; PARASITOLOGY ; Prevalence ; schistosomiasis - acquired immunity - mathematical model - epidemiological values - sensitivity analysis ; Schistosomiasis - immunology ; Schistosomiasis - transmission ; Sensitivity and Specificity ; TROPICAL MEDICINE</subject><ispartof>Memórias do Instituto Oswaldo Cruz, 1998-01, Vol.93 (suppl 1), p.63-73</ispartof><rights>Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b435t-1131c2c9b6f152ba2bdbb69544c023786812f3dc65106e9156f63711d879ec463</citedby><cites>FETCH-LOGICAL-b435t-1131c2c9b6f152ba2bdbb69544c023786812f3dc65106e9156f63711d879ec463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930,79431</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9921325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, H M</creatorcontrib><creatorcontrib>Yang, A C</creatorcontrib><title>The Stabilizing Effects of the Acquired Immunity on the Schistosomiasis Transmission Modeling - The Sensitivity Analysis</title><title>Memórias do Instituto Oswaldo Cruz</title><addtitle>Mem Inst Oswaldo Cruz</addtitle><description>A mathematical model is proposed to analyze the effects of acquired
immunity on the transmission of schistosomiasis in the human host. From
this model the prevalence curve dependent on four parameters can be
obtained. These parameters were estimated fitting the data by the
maximum likelihood method. The model showed a good retrieving capacity
of real data from two endemic areas of schistosomiasis: Touros, Brazil
(Schistosoma mansoni) and Misungwi, Tanzania (S. haematobium). Also,
the average worm burden per person and the dispersion of parasite per
person in the community can be obtained from the model. In this paper,
the stabilizing effects of the acquired immunity assumption in the
model are assessed in terms of the epidemiological variables as
follows. Regarded to the prevalence curve, we calculate the confidence
interval, and related to the average worm burden and the worm
dispersion in the community, the sensitivity analysis (the range of the
variation) of both variables with respect to their parameters is
performed.</description><subject>Animals</subject><subject>Confidence Intervals</subject><subject>Host-Parasite Interactions - immunology</subject><subject>Humans</subject><subject>Models, Immunological</subject><subject>PARASITOLOGY</subject><subject>Prevalence</subject><subject>schistosomiasis - acquired immunity - mathematical model - epidemiological values - sensitivity analysis</subject><subject>Schistosomiasis - immunology</subject><subject>Schistosomiasis - transmission</subject><subject>Sensitivity and Specificity</subject><subject>TROPICAL MEDICINE</subject><issn>1678-8060</issn><issn>0074-0276</issn><issn>0074-0276</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><recordid>eNp9UU1v3CAQRVWrdJP2J1TxqTcnDGBsjqsoX1KiHnZ7RoBxQ2SbhLGrbH992exmc6hUCYRm5r03wxtCToGeQaXoOVJai5KyWoJSDc1RvlR9IItD4SNZgKybsqGSfibHiI80p7kUR-RIKQacVQvysn7wxWoyNvThTxh_FZdd592EReyKKZeW7nkOybfF7TDMY5g2RRxfCyv3EHCKGIdgMGCxTmbEISCGDLiPre-3amXxqu9HDFP4vaUvR9NvMuEL-dSZHv3X_XtCfl5dri9uyrsf17cXy7vSCl5NJQAHx5yysoOKWcNsa61UlRCOMl43sgHW8dbJCqj0CirZSV4DtE2tvBOSn5CznS664PuoH-Oc8gioV1uj9D8OZsL3HeEpxefZ46Tzr5zvezP6OKOWCkRTC5qB9Q7oUkRMvtNPKQwmbTRQvV3Sf1p827eY7eDbA2-_lfeZbYjZRn8AuBSMfktGl49qQDD-F3vRm_U</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Yang, H M</creator><creator>Yang, A C</creator><general>Fundação Oswaldo Cruz, Fiocruz</general><general>Instituto Oswaldo Cruz, Ministério da Saúde</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>19980101</creationdate><title>The Stabilizing Effects of the Acquired Immunity on the Schistosomiasis Transmission Modeling - The Sensitivity Analysis</title><author>Yang, H M ; Yang, A C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b435t-1131c2c9b6f152ba2bdbb69544c023786812f3dc65106e9156f63711d879ec463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Confidence Intervals</topic><topic>Host-Parasite Interactions - immunology</topic><topic>Humans</topic><topic>Models, Immunological</topic><topic>PARASITOLOGY</topic><topic>Prevalence</topic><topic>schistosomiasis - acquired immunity - mathematical model - epidemiological values - sensitivity analysis</topic><topic>Schistosomiasis - immunology</topic><topic>Schistosomiasis - transmission</topic><topic>Sensitivity and Specificity</topic><topic>TROPICAL MEDICINE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, H M</creatorcontrib><creatorcontrib>Yang, A C</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Memórias do Instituto Oswaldo Cruz</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, H M</au><au>Yang, A C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Stabilizing Effects of the Acquired Immunity on the Schistosomiasis Transmission Modeling - The Sensitivity Analysis</atitle><jtitle>Memórias do Instituto Oswaldo Cruz</jtitle><addtitle>Mem Inst Oswaldo Cruz</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>93</volume><issue>suppl 1</issue><spage>63</spage><epage>73</epage><pages>63-73</pages><issn>1678-8060</issn><issn>0074-0276</issn><eissn>0074-0276</eissn><abstract>A mathematical model is proposed to analyze the effects of acquired
immunity on the transmission of schistosomiasis in the human host. From
this model the prevalence curve dependent on four parameters can be
obtained. These parameters were estimated fitting the data by the
maximum likelihood method. The model showed a good retrieving capacity
of real data from two endemic areas of schistosomiasis: Touros, Brazil
(Schistosoma mansoni) and Misungwi, Tanzania (S. haematobium). Also,
the average worm burden per person and the dispersion of parasite per
person in the community can be obtained from the model. In this paper,
the stabilizing effects of the acquired immunity assumption in the
model are assessed in terms of the epidemiological variables as
follows. Regarded to the prevalence curve, we calculate the confidence
interval, and related to the average worm burden and the worm
dispersion in the community, the sensitivity analysis (the range of the
variation) of both variables with respect to their parameters is
performed.</abstract><cop>Brazil</cop><pub>Fundação Oswaldo Cruz, Fiocruz</pub><pmid>9921325</pmid><doi>10.1590/s0074-02761998000700009</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1678-8060 |
| ispartof | Memórias do Instituto Oswaldo Cruz, 1998-01, Vol.93 (suppl 1), p.63-73 |
| issn | 1678-8060 0074-0276 0074-0276 |
| language | eng |
| recordid | cdi_scielo_journals_S0074_02761998000700009 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International |
| subjects | Animals Confidence Intervals Host-Parasite Interactions - immunology Humans Models, Immunological PARASITOLOGY Prevalence schistosomiasis - acquired immunity - mathematical model - epidemiological values - sensitivity analysis Schistosomiasis - immunology Schistosomiasis - transmission Sensitivity and Specificity TROPICAL MEDICINE |
| title | The Stabilizing Effects of the Acquired Immunity on the Schistosomiasis Transmission Modeling - The Sensitivity Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T16%3A31%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_sciel&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Stabilizing%20Effects%20of%20the%20Acquired%20Immunity%20on%20the%20Schistosomiasis%20Transmission%20Modeling%20-%20The%20Sensitivity%20Analysis&rft.jtitle=Mem%C3%B3rias%20do%20Instituto%20Oswaldo%20Cruz&rft.au=Yang,%20H%20M&rft.date=1998-01-01&rft.volume=93&rft.issue=suppl%201&rft.spage=63&rft.epage=73&rft.pages=63-73&rft.issn=1678-8060&rft.eissn=0074-0276&rft_id=info:doi/10.1590/s0074-02761998000700009&rft_dat=%3Cproquest_sciel%3E69148740%3C/proquest_sciel%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69148740&rft_id=info:pmid/9921325&rft_scielo_id=S0074_02761998000700009&rfr_iscdi=true |