Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression
Medical charts and radiographs from 38 HIV-infected patients with positive cultures for Mycobacterium tuberculosis from sputum or bronchoalveolar lavage were reviewed in order to compare the clinical, radiographic, and sputum bacilloscopy characteristics of HIV-infected patients with pulmonary tuber...
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| Veröffentlicht in: | Revista da Sociedade Brasileira de Medicina Tropical 2007-12, Vol.40 (6), p.622-626 |
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| creator | Garcia, Guilherme Freire Moura, Alexandre Sampaio Ferreira, Cid Sérgio Rocha, Manoel Otávio da Costa |
| description | Medical charts and radiographs from 38 HIV-infected patients with positive cultures for Mycobacterium tuberculosis from sputum or bronchoalveolar lavage were reviewed in order to compare the clinical, radiographic, and sputum bacilloscopy characteristics of HIV-infected patients with pulmonary tuberculosis according to CD4+ lymphocyte count (CD4). The mean age of the patients was 32 years and 76% were male. The median CD4 was 106 cells/mm(3) and 71% had CD4 < 200 cells/mm(3). Sputum bacilloscopy was positive in 45% of the patients. Patients with CD4 < 200 cells/mm(3) showed significantly less post-primary pattern (7% vs. 63%; p = 0.02) and more frequently reported weight loss (p = 0.04). Although not statistically significant, patients with lower CD4 showed lower positivity of sputum bacilloscopy (37% vs. 64%; p = 0.18). HIV-infected patients with culture-confirmed pulmonary tuberculosis had a high proportion of non-post-primary pattern in thoracic radiographs. Patients with CD4 lower than 200 cells/mm(3) showed post-primary patterns less frequently and reported weight loss more frequently. |
| doi_str_mv | 10.1590/s0037-86822007000600004 |
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The mean age of the patients was 32 years and 76% were male. The median CD4 was 106 cells/mm(3) and 71% had CD4 < 200 cells/mm(3). Sputum bacilloscopy was positive in 45% of the patients. Patients with CD4 < 200 cells/mm(3) showed significantly less post-primary pattern (7% vs. 63%; p = 0.02) and more frequently reported weight loss (p = 0.04). Although not statistically significant, patients with lower CD4 showed lower positivity of sputum bacilloscopy (37% vs. 64%; p = 0.18). HIV-infected patients with culture-confirmed pulmonary tuberculosis had a high proportion of non-post-primary pattern in thoracic radiographs. Patients with CD4 lower than 200 cells/mm(3) showed post-primary patterns less frequently and reported weight loss more frequently.</description><identifier>ISSN: 0037-8682</identifier><identifier>ISSN: 1678-9849</identifier><identifier>EISSN: 0037-8682</identifier><identifier>EISSN: 1678-9849</identifier><identifier>DOI: 10.1590/s0037-86822007000600004</identifier><identifier>PMID: 18200412</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Medicina Tropical</publisher><subject>Adult ; AIDS-Related Opportunistic Infections - diagnosis ; AIDS-Related Opportunistic Infections - diagnostic imaging ; AIDS-Related Opportunistic Infections - immunology ; Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count ; Cross-Sectional Studies ; Female ; Humans ; Immunosuppression ; Male ; Middle Aged ; Multivariate Analysis ; Mycobacterium tuberculosis - isolation & purification ; Radiography ; Sputum - microbiology ; TROPICAL MEDICINE ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - diagnostic imaging ; Tuberculosis, Pulmonary - immunology</subject><ispartof>Revista da Sociedade Brasileira de Medicina Tropical, 2007-12, Vol.40 (6), p.622-626</ispartof><rights>Copyright Sociedade Brasileira de Medicina Tropical Nov/Dec 2007</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4084-5a4e9cf7cc89b9b95f03097c8e740f56fc78b6b39f104192b5df465e0d197f563</citedby><cites>FETCH-LOGICAL-c4084-5a4e9cf7cc89b9b95f03097c8e740f56fc78b6b39f104192b5df465e0d197f563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,860,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18200412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia, Guilherme Freire</creatorcontrib><creatorcontrib>Moura, Alexandre Sampaio</creatorcontrib><creatorcontrib>Ferreira, Cid Sérgio</creatorcontrib><creatorcontrib>Rocha, Manoel Otávio da Costa</creatorcontrib><title>Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression</title><title>Revista da Sociedade Brasileira de Medicina Tropical</title><addtitle>Rev Soc Bras Med Trop</addtitle><description>Medical charts and radiographs from 38 HIV-infected patients with positive cultures for Mycobacterium tuberculosis from sputum or bronchoalveolar lavage were reviewed in order to compare the clinical, radiographic, and sputum bacilloscopy characteristics of HIV-infected patients with pulmonary tuberculosis according to CD4+ lymphocyte count (CD4). The mean age of the patients was 32 years and 76% were male. The median CD4 was 106 cells/mm(3) and 71% had CD4 < 200 cells/mm(3). Sputum bacilloscopy was positive in 45% of the patients. Patients with CD4 < 200 cells/mm(3) showed significantly less post-primary pattern (7% vs. 63%; p = 0.02) and more frequently reported weight loss (p = 0.04). Although not statistically significant, patients with lower CD4 showed lower positivity of sputum bacilloscopy (37% vs. 64%; p = 0.18). HIV-infected patients with culture-confirmed pulmonary tuberculosis had a high proportion of non-post-primary pattern in thoracic radiographs. Patients with CD4 lower than 200 cells/mm(3) showed post-primary patterns less frequently and reported weight loss more frequently.</description><subject>Adult</subject><subject>AIDS-Related Opportunistic Infections - diagnosis</subject><subject>AIDS-Related Opportunistic Infections - diagnostic imaging</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>CD4 Lymphocyte Count</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Radiography</subject><subject>Sputum - microbiology</subject><subject>TROPICAL MEDICINE</subject><subject>Tuberculosis, Pulmonary - diagnosis</subject><subject>Tuberculosis, Pulmonary - diagnostic imaging</subject><subject>Tuberculosis, Pulmonary - 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Academic</collection><collection>SciELO</collection><jtitle>Revista da Sociedade Brasileira de Medicina Tropical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia, Guilherme Freire</au><au>Moura, Alexandre Sampaio</au><au>Ferreira, Cid Sérgio</au><au>Rocha, Manoel Otávio da Costa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression</atitle><jtitle>Revista da Sociedade Brasileira de Medicina Tropical</jtitle><addtitle>Rev Soc Bras Med Trop</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>40</volume><issue>6</issue><spage>622</spage><epage>626</epage><pages>622-626</pages><issn>0037-8682</issn><issn>1678-9849</issn><eissn>0037-8682</eissn><eissn>1678-9849</eissn><abstract>Medical charts and radiographs from 38 HIV-infected patients with positive cultures for Mycobacterium tuberculosis from sputum or bronchoalveolar lavage were reviewed in order to compare the clinical, radiographic, and sputum bacilloscopy characteristics of HIV-infected patients with pulmonary tuberculosis according to CD4+ lymphocyte count (CD4). The mean age of the patients was 32 years and 76% were male. The median CD4 was 106 cells/mm(3) and 71% had CD4 < 200 cells/mm(3). Sputum bacilloscopy was positive in 45% of the patients. Patients with CD4 < 200 cells/mm(3) showed significantly less post-primary pattern (7% vs. 63%; p = 0.02) and more frequently reported weight loss (p = 0.04). Although not statistically significant, patients with lower CD4 showed lower positivity of sputum bacilloscopy (37% vs. 64%; p = 0.18). HIV-infected patients with culture-confirmed pulmonary tuberculosis had a high proportion of non-post-primary pattern in thoracic radiographs. Patients with CD4 lower than 200 cells/mm(3) showed post-primary patterns less frequently and reported weight loss more frequently.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Medicina Tropical</pub><pmid>18200412</pmid><doi>10.1590/s0037-86822007000600004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult AIDS-Related Opportunistic Infections - diagnosis AIDS-Related Opportunistic Infections - diagnostic imaging AIDS-Related Opportunistic Infections - immunology Antiretroviral Therapy, Highly Active CD4 Lymphocyte Count Cross-Sectional Studies Female Humans Immunosuppression Male Middle Aged Multivariate Analysis Mycobacterium tuberculosis - isolation & purification Radiography Sputum - microbiology TROPICAL MEDICINE Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - diagnostic imaging Tuberculosis, Pulmonary - immunology |
| title | Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression |
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