SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma...
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| Veröffentlicht in: | Revista do Instituto de Medicina Tropical de São Paulo 2022, Vol.64, p.e39-8 |
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| creator | Mobile, Rafael Zancan Warnawin, Stephanie von Stein Cubas Kojo, Teresinha Keiko Rodrigues, Jéssica Alline Pereira Cavilha, Adriana Mendes de Quadros Zerbinati, Rodrigo Melim Adamoski, Douglas Oliveira, Jaqueline Carvalho de Conzentino, Marcelo Santos Huergo, Luciano Fernandes Gradia, Daniela Fiori Braz-Silva, Paulo Henrique Schussel, Juliana Lucena |
| description | This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario. |
| doi_str_mv | 10.1590/S1678-9946202264039 |
| format | Article |
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In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.</description><identifier>ISSN: 1678-9946</identifier><identifier>ISSN: 0036-4665</identifier><identifier>EISSN: 1678-9946</identifier><identifier>DOI: 10.1590/S1678-9946202264039</identifier><identifier>PMID: 35674637</identifier><language>eng</language><publisher>Brazil: Instituto de Medicina Tropical de Sao Paulo</publisher><subject>Antibodies, Viral ; Cohort analysis ; Coronaviruses ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; Dentists ; Disease ; Health Personnel ; Health surveillance ; Hematopoietic Stem Cell Transplantation ; Hospitals ; Humans ; Infections ; Medical personnel ; Mortality ; Nurses ; Original ; Plasma ; Prospective Studies ; Questionnaires ; RNA polymerase ; Saliva ; SARS-CoV-2 ; Seroepidemiologic Studies ; Serology ; Severe acute respiratory syndrome coronavirus 2 ; Sociodemographics ; Stem cell transplantation ; TROPICAL MEDICINE ; Viral infections ; Viremia</subject><ispartof>Revista do Instituto de Medicina Tropical de São Paulo, 2022, Vol.64, p.e39-8</ispartof><rights>2022. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). 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In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.</description><subject>Antibodies, Viral</subject><subject>Cohort analysis</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>Dentists</subject><subject>Disease</subject><subject>Health Personnel</subject><subject>Health surveillance</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Medical personnel</subject><subject>Mortality</subject><subject>Nurses</subject><subject>Original</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Questionnaires</subject><subject>RNA polymerase</subject><subject>Saliva</subject><subject>SARS-CoV-2</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Sociodemographics</subject><subject>Stem cell transplantation</subject><subject>TROPICAL MEDICINE</subject><subject>Viral 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Rafael Zancan</creator><creator>Warnawin, Stephanie von Stein Cubas</creator><creator>Kojo, Teresinha Keiko</creator><creator>Rodrigues, Jéssica Alline Pereira</creator><creator>Cavilha, Adriana Mendes de Quadros</creator><creator>Zerbinati, Rodrigo Melim</creator><creator>Adamoski, Douglas</creator><creator>Oliveira, Jaqueline Carvalho de</creator><creator>Conzentino, Marcelo Santos</creator><creator>Huergo, Luciano Fernandes</creator><creator>Gradia, Daniela Fiori</creator><creator>Braz-Silva, Paulo Henrique</creator><creator>Schussel, Juliana Lucena</creator><general>Instituto de Medicina Tropical de Sao Paulo</general><general>Instituto de Medicina Tropical de São 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in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study</title><author>Mobile, Rafael Zancan ; Warnawin, Stephanie von Stein Cubas ; Kojo, Teresinha Keiko ; Rodrigues, Jéssica Alline Pereira ; Cavilha, Adriana Mendes de Quadros ; Zerbinati, Rodrigo Melim ; Adamoski, Douglas ; Oliveira, Jaqueline Carvalho de ; Conzentino, Marcelo Santos ; Huergo, Luciano Fernandes ; Gradia, Daniela Fiori ; Braz-Silva, Paulo Henrique ; Schussel, Juliana Lucena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3879-bd226496ab462082ee0cd53ec75e7ae1401af4821549b358432f42234d84382c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies, Viral</topic><topic>Cohort analysis</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - epidemiology</topic><topic>Dentists</topic><topic>Disease</topic><topic>Health Personnel</topic><topic>Health surveillance</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Medical personnel</topic><topic>Mortality</topic><topic>Nurses</topic><topic>Original</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Questionnaires</topic><topic>RNA polymerase</topic><topic>Saliva</topic><topic>SARS-CoV-2</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Sociodemographics</topic><topic>Stem cell transplantation</topic><topic>TROPICAL MEDICINE</topic><topic>Viral infections</topic><topic>Viremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mobile, Rafael Zancan</creatorcontrib><creatorcontrib>Warnawin, Stephanie von Stein 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Paulo Henrique</au><au>Schussel, Juliana Lucena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study</atitle><jtitle>Revista do Instituto de Medicina Tropical de São Paulo</jtitle><addtitle>Rev Inst Med Trop Sao Paulo</addtitle><date>2022</date><risdate>2022</risdate><volume>64</volume><spage>e39</spage><epage>8</epage><pages>e39-8</pages><issn>1678-9946</issn><issn>0036-4665</issn><eissn>1678-9946</eissn><abstract>This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.</abstract><cop>Brazil</cop><pub>Instituto de Medicina Tropical de Sao Paulo</pub><pmid>35674637</pmid><doi>10.1590/S1678-9946202264039</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8603-2614</orcidid><orcidid>https://orcid.org/0000-0001-5204-0782</orcidid><orcidid>https://orcid.org/0000-0002-1842-9521</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Revista do Instituto de Medicina Tropical de São Paulo, 2022, Vol.64, p.e39-8 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Antibodies, Viral Cohort analysis Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology Dentists Disease Health Personnel Health surveillance Hematopoietic Stem Cell Transplantation Hospitals Humans Infections Medical personnel Mortality Nurses Original Plasma Prospective Studies Questionnaires RNA polymerase Saliva SARS-CoV-2 Seroepidemiologic Studies Serology Severe acute respiratory syndrome coronavirus 2 Sociodemographics Stem cell transplantation TROPICAL MEDICINE Viral infections Viremia |
| title | SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study |
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