Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection. II. Corynebacterium parvum
The effects of Corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in Schistosoma mansoni infected mice were studied. The C. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or...
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| Veröffentlicht in: | Revista do Instituto de Medicina Tropical de São Paulo 1996-10, Vol.38 (5), p.359-364 |
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| container_title | Revista do Instituto de Medicina Tropical de São Paulo |
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| creator | Teixeira, K M Coutinho, E M Abath, F G Montenegro, S M |
| description | The effects of Corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in Schistosoma mansoni infected mice were studied. The C. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). The host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.018), resulting in 44% protection. The "in vivo" leukocyte response in both prophylactic and curative groups was higher as compared to the infected/non treated group (p = 0.009 and p = 0.003, respectively). Tissue reactions were described in the experimental and control groups, but there were not remarkable differences among them. The possible biological implications and relevance of the findings for the defensive response of the host and control of schistosomiasis are discussed. |
| doi_str_mv | 10.1590/s0036-46651996000500007 |
| format | Article |
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II. Corynebacterium parvum</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Teixeira, K M ; Coutinho, E M ; Abath, F G ; Montenegro, S M</creator><creatorcontrib>Teixeira, K M ; Coutinho, E M ; Abath, F G ; Montenegro, S M</creatorcontrib><description>The effects of Corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in Schistosoma mansoni infected mice were studied. The C. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). The host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.018), resulting in 44% protection. The "in vivo" leukocyte response in both prophylactic and curative groups was higher as compared to the infected/non treated group (p = 0.009 and p = 0.003, respectively). Tissue reactions were described in the experimental and control groups, but there were not remarkable differences among them. The possible biological implications and relevance of the findings for the defensive response of the host and control of schistosomiasis are discussed.</description><identifier>ISSN: 0036-4665</identifier><identifier>ISSN: 1678-9946</identifier><identifier>EISSN: 0036-4665</identifier><identifier>DOI: 10.1590/s0036-46651996000500007</identifier><identifier>PMID: 9293078</identifier><language>eng</language><publisher>Brazil: Instituto de Medicina Tropical</publisher><subject>Adjuvants, Immunologic - therapeutic use ; Animals ; Chemotaxis, Leukocyte - immunology ; Male ; Mice ; Mice, Inbred C57BL ; Neutrophils - immunology ; Propionibacterium acnes ; Schistosomiasis mansoni - pathology ; Schistosomiasis mansoni - therapy ; TROPICAL MEDICINE</subject><ispartof>Revista do Instituto de Medicina Tropical de São Paulo, 1996-10, Vol.38 (5), p.359-364</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3657-2874f86c9fc35dfba4c74c58d22b5f02d4248129a5f23c32d04ce34f919ecee83</citedby><cites>FETCH-LOGICAL-c3657-2874f86c9fc35dfba4c74c58d22b5f02d4248129a5f23c32d04ce34f919ecee83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9293078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teixeira, K M</creatorcontrib><creatorcontrib>Coutinho, E M</creatorcontrib><creatorcontrib>Abath, F G</creatorcontrib><creatorcontrib>Montenegro, S M</creatorcontrib><title>Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection. II. Corynebacterium parvum</title><title>Revista do Instituto de Medicina Tropical de São Paulo</title><addtitle>Rev Inst Med Trop Sao Paulo</addtitle><description>The effects of Corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in Schistosoma mansoni infected mice were studied. The C. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). The host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.018), resulting in 44% protection. The "in vivo" leukocyte response in both prophylactic and curative groups was higher as compared to the infected/non treated group (p = 0.009 and p = 0.003, respectively). Tissue reactions were described in the experimental and control groups, but there were not remarkable differences among them. The possible biological implications and relevance of the findings for the defensive response of the host and control of schistosomiasis are discussed.</description><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Animals</subject><subject>Chemotaxis, Leukocyte - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neutrophils - immunology</subject><subject>Propionibacterium acnes</subject><subject>Schistosomiasis mansoni - pathology</subject><subject>Schistosomiasis mansoni - therapy</subject><subject>TROPICAL MEDICINE</subject><issn>0036-4665</issn><issn>1678-9946</issn><issn>0036-4665</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1LAzEQDaLUWv0JYk7etmaT_cpRStVCwUP1vGSzE0zZJGuyK_bfm9JSBMHDMMPMe_OGNwjdpWSe5pw8BEJYkWRFkaecF4SQPAYpz9D0NDj_VV-iqxC2EcEJLyZowilnpKymaFgqBXII2ClsnU1CD1IrLbE2ZrSudwPYQYvB-YC1xfDdg9cm9kSHN_JDh8EFZwQ2wgZndcTs12ln53i1muOF8zsLjZBDpI0G98J_jeYaXSjRBbg55hl6f1q-LV6S9evzavG4TiQr8jKhVZmpqpBcSZa3qhGZLDOZVy2lTa4IbTOaVSnlIleUSUZbkklgmeIpBwlQsRmaH_YGqaFz9daN3kbBerM3pv7jXiTcHwi9d58jhKE2OkjoOmHBjaEu40U0pUUElgeg9C4ED6ruoy3C7-qU1PsH_SNxe5QYGwPtiXf8CPsB8rSLkA</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Teixeira, K M</creator><creator>Coutinho, E M</creator><creator>Abath, F G</creator><creator>Montenegro, S M</creator><general>Instituto de Medicina Tropical</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>19961001</creationdate><title>Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection. II. Corynebacterium parvum</title><author>Teixeira, K M ; Coutinho, E M ; Abath, F G ; Montenegro, S M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3657-2874f86c9fc35dfba4c74c58d22b5f02d4248129a5f23c32d04ce34f919ecee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Animals</topic><topic>Chemotaxis, Leukocyte - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neutrophils - immunology</topic><topic>Propionibacterium acnes</topic><topic>Schistosomiasis mansoni - pathology</topic><topic>Schistosomiasis mansoni - therapy</topic><topic>TROPICAL MEDICINE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teixeira, K M</creatorcontrib><creatorcontrib>Coutinho, E M</creatorcontrib><creatorcontrib>Abath, F G</creatorcontrib><creatorcontrib>Montenegro, S M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Revista do Instituto de Medicina Tropical de São Paulo</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teixeira, K M</au><au>Coutinho, E M</au><au>Abath, F G</au><au>Montenegro, S M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection. II. Corynebacterium parvum</atitle><jtitle>Revista do Instituto de Medicina Tropical de São Paulo</jtitle><addtitle>Rev Inst Med Trop Sao Paulo</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>38</volume><issue>5</issue><spage>359</spage><epage>364</epage><pages>359-364</pages><issn>0036-4665</issn><issn>1678-9946</issn><eissn>0036-4665</eissn><abstract>The effects of Corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in Schistosoma mansoni infected mice were studied. The C. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). The host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.018), resulting in 44% protection. The "in vivo" leukocyte response in both prophylactic and curative groups was higher as compared to the infected/non treated group (p = 0.009 and p = 0.003, respectively). Tissue reactions were described in the experimental and control groups, but there were not remarkable differences among them. The possible biological implications and relevance of the findings for the defensive response of the host and control of schistosomiasis are discussed.</abstract><cop>Brazil</cop><pub>Instituto de Medicina Tropical</pub><pmid>9293078</pmid><doi>10.1590/s0036-46651996000500007</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0036-4665 1678-9946 0036-4665 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adjuvants, Immunologic - therapeutic use Animals Chemotaxis, Leukocyte - immunology Male Mice Mice, Inbred C57BL Neutrophils - immunology Propionibacterium acnes Schistosomiasis mansoni - pathology Schistosomiasis mansoni - therapy TROPICAL MEDICINE |
| title | Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection. II. Corynebacterium parvum |
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