The value of adenosine deaminase (ADA) determination in the diagnosis of tuberculous ascites
In order to evaluate the role of the determination of adenosine deaminase activity (ADA) in ascitic fluid for the diagnosis of tuberculosis, 44 patients were studied. Based on biochemical, cytological, histopathological and microbiological tests, the patients were divided into 5 groups: G1-tuberculo...
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Veröffentlicht in: | Revista do Instituto de Medicina Tropical de São Paulo 1995-10, Vol.37 (5), p.449-453 |
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description | In order to evaluate the role of the determination of adenosine deaminase activity (ADA) in ascitic fluid for the diagnosis of tuberculosis, 44 patients were studied. Based on biochemical, cytological, histopathological and microbiological tests, the patients were divided into 5 groups: G1-tuberculous ascites (n = 8); G2-malignant ascites (n = 13); G3-spontaneous bacterial peritonitis (n = 6); G4-pancreatic ascites (n = 2); G5-miscelaneous ascites (n = 15). ADA concentration were significantly higher in G1 (133.50 +/- 24.74 U/l) compared to the other groups (G2 = 41.85 +/- 52.07 U/l; G3 = 10.63 +/- 5.87 U/l; G4 = 18.00 +/- 7.07 U/l; G5 = 11.23 +/- 7.66 U/l). At a cut-off value of > 31 U/l, the sensitivity, specificity and positive and negative predictive values were 100%, 92%, 72% and 100%, respectively. ADA concentrations as high as in tuberculous ascites were only found in two malignant ascites caused by lymphoma. We conclude that ADA determination in ascitic fluid is a useful and reliable screening test for diagnosing tuberculous ascites. Values of ADA higher than 31 U/l indicate more invasive methods to confirm the diagnosis of tuberculosis. |
doi_str_mv | 10.1590/S0036-46651995000500011 |
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Based on biochemical, cytological, histopathological and microbiological tests, the patients were divided into 5 groups: G1-tuberculous ascites (n = 8); G2-malignant ascites (n = 13); G3-spontaneous bacterial peritonitis (n = 6); G4-pancreatic ascites (n = 2); G5-miscelaneous ascites (n = 15). ADA concentration were significantly higher in G1 (133.50 +/- 24.74 U/l) compared to the other groups (G2 = 41.85 +/- 52.07 U/l; G3 = 10.63 +/- 5.87 U/l; G4 = 18.00 +/- 7.07 U/l; G5 = 11.23 +/- 7.66 U/l). At a cut-off value of > 31 U/l, the sensitivity, specificity and positive and negative predictive values were 100%, 92%, 72% and 100%, respectively. ADA concentrations as high as in tuberculous ascites were only found in two malignant ascites caused by lymphoma. We conclude that ADA determination in ascitic fluid is a useful and reliable screening test for diagnosing tuberculous ascites. Values of ADA higher than 31 U/l indicate more invasive methods to confirm the diagnosis of tuberculosis.</description><identifier>ISSN: 0036-4665</identifier><identifier>ISSN: 1678-9946</identifier><identifier>EISSN: 0036-4665</identifier><identifier>DOI: 10.1590/S0036-46651995000500011</identifier><identifier>PMID: 8729756</identifier><language>eng</language><publisher>Brazil: Instituto de Medicina Tropical</publisher><subject>Adenosine Deaminase - metabolism ; Ascitic Fluid - diagnosis ; Clinical Enzyme Tests ; Humans ; Peritonitis, Tuberculous - diagnosis ; Prospective Studies ; Sensitivity and Specificity ; TROPICAL MEDICINE</subject><ispartof>Revista do Instituto de Medicina Tropical de São Paulo, 1995-10, Vol.37 (5), p.449-453</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3111-61af77bf443dfd22c70b4ceac6343b274164dc0d1c87cfb3621e02ce816c8a763</citedby><cites>FETCH-LOGICAL-c3111-61af77bf443dfd22c70b4ceac6343b274164dc0d1c87cfb3621e02ce816c8a763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8729756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brant, C Q</creatorcontrib><creatorcontrib>Silva, Jr, M R</creatorcontrib><creatorcontrib>Macedo, E P</creatorcontrib><creatorcontrib>Vasconcelos, C</creatorcontrib><creatorcontrib>Tamaki, N</creatorcontrib><creatorcontrib>Ferraz, M L</creatorcontrib><title>The value of adenosine deaminase (ADA) determination in the diagnosis of tuberculous ascites</title><title>Revista do Instituto de Medicina Tropical de São Paulo</title><addtitle>Rev Inst Med Trop Sao Paulo</addtitle><description>In order to evaluate the role of the determination of adenosine deaminase activity (ADA) in ascitic fluid for the diagnosis of tuberculosis, 44 patients were studied. Based on biochemical, cytological, histopathological and microbiological tests, the patients were divided into 5 groups: G1-tuberculous ascites (n = 8); G2-malignant ascites (n = 13); G3-spontaneous bacterial peritonitis (n = 6); G4-pancreatic ascites (n = 2); G5-miscelaneous ascites (n = 15). ADA concentration were significantly higher in G1 (133.50 +/- 24.74 U/l) compared to the other groups (G2 = 41.85 +/- 52.07 U/l; G3 = 10.63 +/- 5.87 U/l; G4 = 18.00 +/- 7.07 U/l; G5 = 11.23 +/- 7.66 U/l). At a cut-off value of > 31 U/l, the sensitivity, specificity and positive and negative predictive values were 100%, 92%, 72% and 100%, respectively. ADA concentrations as high as in tuberculous ascites were only found in two malignant ascites caused by lymphoma. We conclude that ADA determination in ascitic fluid is a useful and reliable screening test for diagnosing tuberculous ascites. Values of ADA higher than 31 U/l indicate more invasive methods to confirm the diagnosis of tuberculosis.</description><subject>Adenosine Deaminase - metabolism</subject><subject>Ascitic Fluid - diagnosis</subject><subject>Clinical Enzyme Tests</subject><subject>Humans</subject><subject>Peritonitis, Tuberculous - diagnosis</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>TROPICAL MEDICINE</subject><issn>0036-4665</issn><issn>1678-9946</issn><issn>0036-4665</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV9LwzAUxYMoc04_gpgn0YfOpGmT9nHMvzDwwfkmhDS51YyumUkr-O1N3RBB8CHc5Ob87gknCJ1RMqV5Sa6eCGE8yTjPaVnmhJBhUbqHxj8X-7_2h-gohFWUlKTkIzQqRFqKnI_Ry_IN8IdqesCuxspA64JtARtQa9uqAPhidj27jOcO_NDprGuxbXEXOWPV66APA9v1FXjdN64PWAVtOwjH6KBWTYCTXZ2g59ub5fw-WTzePcxni0QzSmnCqaqFqOosY6Y2aaoFqTINSnOWsSoVGeWZ0cRQXQhdV4ynFEiqoaBcF0pwNkHT7dxoC42TK9f7NhrK75Tkn5QicL4FNt699xA6ubZBQ9OoFuL7pRAlyZkoolBshdq7EDzUcuPtWvlPSYkcPuIfi9OdRV-twfxwu-TZF3MvgOA</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Brant, C Q</creator><creator>Silva, Jr, M R</creator><creator>Macedo, E P</creator><creator>Vasconcelos, C</creator><creator>Tamaki, N</creator><creator>Ferraz, M L</creator><general>Instituto de Medicina Tropical</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>19951001</creationdate><title>The value of adenosine deaminase (ADA) determination in the diagnosis of tuberculous ascites</title><author>Brant, C Q ; Silva, Jr, M R ; Macedo, E P ; Vasconcelos, C ; Tamaki, N ; Ferraz, M L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3111-61af77bf443dfd22c70b4ceac6343b274164dc0d1c87cfb3621e02ce816c8a763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adenosine Deaminase - metabolism</topic><topic>Ascitic Fluid - diagnosis</topic><topic>Clinical Enzyme Tests</topic><topic>Humans</topic><topic>Peritonitis, Tuberculous - diagnosis</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>TROPICAL MEDICINE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brant, C Q</creatorcontrib><creatorcontrib>Silva, Jr, M R</creatorcontrib><creatorcontrib>Macedo, E P</creatorcontrib><creatorcontrib>Vasconcelos, C</creatorcontrib><creatorcontrib>Tamaki, N</creatorcontrib><creatorcontrib>Ferraz, M L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Revista do Instituto de Medicina Tropical de São Paulo</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brant, C Q</au><au>Silva, Jr, M R</au><au>Macedo, E P</au><au>Vasconcelos, C</au><au>Tamaki, N</au><au>Ferraz, M L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of adenosine deaminase (ADA) determination in the diagnosis of tuberculous ascites</atitle><jtitle>Revista do Instituto de Medicina Tropical de São Paulo</jtitle><addtitle>Rev Inst Med Trop Sao Paulo</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>37</volume><issue>5</issue><spage>449</spage><epage>453</epage><pages>449-453</pages><issn>0036-4665</issn><issn>1678-9946</issn><eissn>0036-4665</eissn><abstract>In order to evaluate the role of the determination of adenosine deaminase activity (ADA) in ascitic fluid for the diagnosis of tuberculosis, 44 patients were studied. Based on biochemical, cytological, histopathological and microbiological tests, the patients were divided into 5 groups: G1-tuberculous ascites (n = 8); G2-malignant ascites (n = 13); G3-spontaneous bacterial peritonitis (n = 6); G4-pancreatic ascites (n = 2); G5-miscelaneous ascites (n = 15). ADA concentration were significantly higher in G1 (133.50 +/- 24.74 U/l) compared to the other groups (G2 = 41.85 +/- 52.07 U/l; G3 = 10.63 +/- 5.87 U/l; G4 = 18.00 +/- 7.07 U/l; G5 = 11.23 +/- 7.66 U/l). At a cut-off value of > 31 U/l, the sensitivity, specificity and positive and negative predictive values were 100%, 92%, 72% and 100%, respectively. ADA concentrations as high as in tuberculous ascites were only found in two malignant ascites caused by lymphoma. We conclude that ADA determination in ascitic fluid is a useful and reliable screening test for diagnosing tuberculous ascites. Values of ADA higher than 31 U/l indicate more invasive methods to confirm the diagnosis of tuberculosis.</abstract><cop>Brazil</cop><pub>Instituto de Medicina Tropical</pub><pmid>8729756</pmid><doi>10.1590/S0036-46651995000500011</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adenosine Deaminase - metabolism Ascitic Fluid - diagnosis Clinical Enzyme Tests Humans Peritonitis, Tuberculous - diagnosis Prospective Studies Sensitivity and Specificity TROPICAL MEDICINE |
title | The value of adenosine deaminase (ADA) determination in the diagnosis of tuberculous ascites |
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