Possible oral transmission of acute chagas' disease in Brazil
In October 1986, 7 to 22 days after a meeting at a farm in Paraíba state, 26 individuals presented with a febrile illness associated with bilateral eyelid and lower limb edema, mild hepatosplenomegaly, lymphadenopathy and, occasionally a skin rash. A 11-year-old boy exhibited atrial premature comple...
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| Veröffentlicht in: | Revista do Instituto de Medicina Tropical de São Paulo 1991-09, Vol.33 (5), p.351-357 |
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| creator | SHIKANAI-YASUDA, M. A BRISOLA MARCONDES, C LOPES, M. H SHIROMA, M CHAPADEIRO, E GUEDES, L. A SIQUEIRA, G. S BARONE, A. A DIAS, J. C. P AMATO NETO, V TOLEZANO, J. E PERES, B. A ARRUDA, E. R |
| description | In October 1986, 7 to 22 days after a meeting at a farm in Paraíba state, 26 individuals presented with a febrile illness associated with bilateral eyelid and lower limb edema, mild hepatosplenomegaly, lymphadenopathy and, occasionally a skin rash. A 11-year-old boy exhibited atrial premature complexes and a 74-year-old patient developed acute heart failure. In two patients hospitalized in São Paulo city, acute Chagas' disease was diagnosed by the demonstration of circulating Trypanosoma cruzi. At autopsy in a fatal case, acute Chagas' cardiomyopathy was demonstrated. Xenodiagnosis were positive in 9 out of 14 tested patients. A specific IgG immune response was found in all patients and specific IgM antibodies were identified in 20 out of 22 tested patients. A epidemiological survey showed the existence of Triatoma brasiliensis in the outbuildings of this farm, but none in the house where most of the guests stayed. A high rate of infection with Trypanosoma cruzi was found in opossums. These observations together with those related to the food consumed by the patients, lead the authors to suggest that the human infections resulted from oral contamination probably originating from naturally infected marsupials in the area or crushed infected bugs. |
| doi_str_mv | 10.1590/S0036-46651991000500003 |
| format | Article |
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A ; BRISOLA MARCONDES, C ; LOPES, M. H ; SHIROMA, M ; CHAPADEIRO, E ; GUEDES, L. A ; SIQUEIRA, G. S ; BARONE, A. A ; DIAS, J. C. P ; AMATO NETO, V ; TOLEZANO, J. E ; PERES, B. A ; ARRUDA, E. R</creator><creatorcontrib>SHIKANAI-YASUDA, M. A ; BRISOLA MARCONDES, C ; LOPES, M. H ; SHIROMA, M ; CHAPADEIRO, E ; GUEDES, L. A ; SIQUEIRA, G. S ; BARONE, A. A ; DIAS, J. C. P ; AMATO NETO, V ; TOLEZANO, J. E ; PERES, B. A ; ARRUDA, E. R</creatorcontrib><description>In October 1986, 7 to 22 days after a meeting at a farm in Paraíba state, 26 individuals presented with a febrile illness associated with bilateral eyelid and lower limb edema, mild hepatosplenomegaly, lymphadenopathy and, occasionally a skin rash. A 11-year-old boy exhibited atrial premature complexes and a 74-year-old patient developed acute heart failure. In two patients hospitalized in São Paulo city, acute Chagas' disease was diagnosed by the demonstration of circulating Trypanosoma cruzi. At autopsy in a fatal case, acute Chagas' cardiomyopathy was demonstrated. Xenodiagnosis were positive in 9 out of 14 tested patients. A specific IgG immune response was found in all patients and specific IgM antibodies were identified in 20 out of 22 tested patients. A epidemiological survey showed the existence of Triatoma brasiliensis in the outbuildings of this farm, but none in the house where most of the guests stayed. A high rate of infection with Trypanosoma cruzi was found in opossums. 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A epidemiological survey showed the existence of Triatoma brasiliensis in the outbuildings of this farm, but none in the house where most of the guests stayed. A high rate of infection with Trypanosoma cruzi was found in opossums. These observations together with those related to the food consumed by the patients, lead the authors to suggest that the human infections resulted from oral contamination probably originating from naturally infected marsupials in the area or crushed infected bugs.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brazil - epidemiology</subject><subject>Chagas Disease - epidemiology</subject><subject>Chagas Disease - transmission</subject><subject>Child</subject><subject>Disease Outbreaks</subject><subject>Disease Vectors</subject><subject>Female</subject><subject>Food Contamination</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Marsupialia - parasitology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Time Factors</subject><subject>TROPICAL MEDICINE</subject><subject>Trypanosomiasis</subject><issn>0036-4665</issn><issn>1678-9946</issn><issn>1678-9946</issn><issn>0036-4665</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVZ_gpiD4GnrJJudbA4etPgFBQX1vEx3E03ZdkvSHvTXG12pB8HDEJj3fRLyMHYiYCwKA-dPADlmCrEQxggAKNJAvsOGAnWZGaNwlw23pX12EOM8NQwYHLCBKJUyKIbs4rGL0c9ay7tALV8HWsaFT6tuyTvHqd6sLa_f6JXiGW98tBQt90t-FejDt4dsz1Eb7dHPOWIvN9fPk7ts-nB7P7mcZrWSxTprZqXQgnJdlAJyaSVKAumULiVqZwSVYIRBRG2kFQo1OVXKBo0TkshgPmLj_t5Ye9t21bzbhGV6sPrWUP3RkADdA3VI_wvWVavgFxTeKwHVl8B_yOOeXG1mC9v8cr2xlJ_-5BRral0SVvu4rRWABeQ6_wQFFHML</recordid><startdate>19910901</startdate><enddate>19910901</enddate><creator>SHIKANAI-YASUDA, M. 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R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible oral transmission of acute chagas' disease in Brazil</atitle><jtitle>Revista do Instituto de Medicina Tropical de São Paulo</jtitle><addtitle>Rev Inst Med Trop Sao Paulo</addtitle><date>1991-09-01</date><risdate>1991</risdate><volume>33</volume><issue>5</issue><spage>351</spage><epage>357</epage><pages>351-357</pages><issn>0036-4665</issn><issn>1678-9946</issn><eissn>1678-9946</eissn><eissn>0036-4665</eissn><coden>RMTSAE</coden><abstract>In October 1986, 7 to 22 days after a meeting at a farm in Paraíba state, 26 individuals presented with a febrile illness associated with bilateral eyelid and lower limb edema, mild hepatosplenomegaly, lymphadenopathy and, occasionally a skin rash. A 11-year-old boy exhibited atrial premature complexes and a 74-year-old patient developed acute heart failure. In two patients hospitalized in São Paulo city, acute Chagas' disease was diagnosed by the demonstration of circulating Trypanosoma cruzi. At autopsy in a fatal case, acute Chagas' cardiomyopathy was demonstrated. Xenodiagnosis were positive in 9 out of 14 tested patients. A specific IgG immune response was found in all patients and specific IgM antibodies were identified in 20 out of 22 tested patients. A epidemiological survey showed the existence of Triatoma brasiliensis in the outbuildings of this farm, but none in the house where most of the guests stayed. A high rate of infection with Trypanosoma cruzi was found in opossums. 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| ispartof | Revista do Instituto de Medicina Tropical de São Paulo, 1991-09, Vol.33 (5), p.351-357 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Acute Disease Adolescent Adult Aged Animals Biological and medical sciences Brazil - epidemiology Chagas Disease - epidemiology Chagas Disease - transmission Child Disease Outbreaks Disease Vectors Female Food Contamination Human protozoal diseases Humans Infectious diseases Male Marsupialia - parasitology Medical sciences Middle Aged Parasitic diseases Protozoal diseases Time Factors TROPICAL MEDICINE Trypanosomiasis |
| title | Possible oral transmission of acute chagas' disease in Brazil |
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