HLA-DQA104:01 is related to a higher multiple sclerosis lesion load on T2/Flair MRI sequences

ABSTRACT Background: The genetic predisposition to multiple sclerosis (MS) is associated with HLA alleles, especially HLA-DRB1*15:01. Objective: To identify associations between findings in magnetic resonance imaging (MRI) and genetic features in a Brazilian cohort of patients with MS. Methods: We r...

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Veröffentlicht in:	Arquivos de neuro-psiquiatria 2021-12, Vol.79 (12), p.1109-1115
Hauptverfasser:	NORO, Fabio, ALVES-LEON, Soniza Vieira, FONTES-DANTAS, Fabricia Lima, VALLE BAHIA, Paulo Roberto, ANDREIUOLO, Rodrigo Ferrone, RUEDA LOPES, Fernanda Cristina, PEREIRA, Valeria Coelho Santa Rita, ABI-HAILA, Livia de Almeida Afonso, COUTINHO, Renan Amaral, ARAUJO, Amanda Dutra de, MARCHIORI, Edson
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles DQA1 protein Drb1 protein Gene Frequency Genes, MHC Class II Genetic Predisposition to Disease Genotype Histocompatibility antigen HLA HLA-DQ alpha-Chains - genetics HLA-DQ Antigens HLA-DQ beta-Chains HLA-DRB1 Chains HLA-DRB1 Chains - genetics Humans Lesions Magnetic Resonance Imaging Multiple Sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - genetics NEUROSCIENCES Patients Polymerase chain reaction PSYCHIATRY Retrospective Studies Single-nucleotide polymorphism
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