Neuromyelitis optica: phenotypic characteristics in a Brazilian case series
ABSTRACT The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population. Objective To describe the characteristics of 34 Brazilian N...
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| Veröffentlicht in: | Arquivos de neuro-psiquiatria 2017-02, Vol.75 (2), p.81-86 |
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| creator | Del Negro, Maria Cristina Marinho, Patricia Beatriz Christino Papais-Alvarenga, Regina Maria |
| description | ABSTRACT
The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population.
Objective
To describe the characteristics of 34 Brazilian NMO patients. To evaluate the contribution of the 2015 criteria to the diagnosis of NMO spectrum disorders (NMOSD) in 40 patients with longitudinal extensive transverse myelitis (LEMT).
Methods
This is a retrospective, descriptive and analytic study.
Results
Among NMO patients, there was a predominance of women, with onset in the fourth decade of life, and AQP4-IgG seropositivity in 73.5%. The diagnosis of NMOSD was established in 37.5% of LETM patients according to AQP4-IgG positivity and in 5% of LETM patients if the AQP4-IgG result was unknown.
Conclusions
The characteristics of this series are similar to those of other Western populations. The AQP4-IgG testing assists in the diagnosis of NMOSD. |
| doi_str_mv | 10.1590/0004-282X20160193 |
| format | Article |
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The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population.
Objective
To describe the characteristics of 34 Brazilian NMO patients. To evaluate the contribution of the 2015 criteria to the diagnosis of NMO spectrum disorders (NMOSD) in 40 patients with longitudinal extensive transverse myelitis (LEMT).
Methods
This is a retrospective, descriptive and analytic study.
Results
Among NMO patients, there was a predominance of women, with onset in the fourth decade of life, and AQP4-IgG seropositivity in 73.5%. The diagnosis of NMOSD was established in 37.5% of LETM patients according to AQP4-IgG positivity and in 5% of LETM patients if the AQP4-IgG result was unknown.
Conclusions
The characteristics of this series are similar to those of other Western populations. The AQP4-IgG testing assists in the diagnosis of NMOSD.</description><identifier>ISSN: 0004-282X</identifier><identifier>ISSN: 1678-4227</identifier><identifier>EISSN: 1678-4227</identifier><identifier>EISSN: 0004-282X</identifier><identifier>DOI: 10.1590/0004-282X20160193</identifier><identifier>PMID: 28226075</identifier><language>eng</language><publisher>Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil: Thieme Revinter Publicações Ltda</publisher><subject>Adolescent ; Adult ; Aged ; Aquaporin 4 - blood ; Autoantibodies - blood ; Child ; Child, Preschool ; ensaio enzimático ; Enzyme-Linked Immunosorbent Assay ; epidemiologia ; estudo transversal ; Female ; Humans ; Male ; Middle Aged ; neuromielite óptica ; Neuromyelitis Optica - diagnosis ; NEUROSCIENCES ; Phenotype ; PSYCHIATRY ; Retrospective Studies ; Young Adult</subject><ispartof>Arquivos de neuro-psiquiatria, 2017-02, Vol.75 (2), p.81-86</ispartof><rights>Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon.</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-1cbd5cea3d842213b9ea2ba19044a9aae061d9746ee8f76182a09fc09db04e893</citedby><cites>FETCH-LOGICAL-c523t-1cbd5cea3d842213b9ea2ba19044a9aae061d9746ee8f76182a09fc09db04e893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1590/0004-282X20160193.pdf$$EPDF$$P50$$Gthieme$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1590/0004-282X20160193$$EHTML$$P50$$Gthieme$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,860,881,20870,27901,27902,54562,54590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28226075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Del Negro, Maria Cristina</creatorcontrib><creatorcontrib>Marinho, Patricia Beatriz Christino</creatorcontrib><creatorcontrib>Papais-Alvarenga, Regina Maria</creatorcontrib><title>Neuromyelitis optica: phenotypic characteristics in a Brazilian case series</title><title>Arquivos de neuro-psiquiatria</title><addtitle>Arq Neuropsiquiatr</addtitle><description>ABSTRACT
The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population.
Objective
To describe the characteristics of 34 Brazilian NMO patients. To evaluate the contribution of the 2015 criteria to the diagnosis of NMO spectrum disorders (NMOSD) in 40 patients with longitudinal extensive transverse myelitis (LEMT).
Methods
This is a retrospective, descriptive and analytic study.
Results
Among NMO patients, there was a predominance of women, with onset in the fourth decade of life, and AQP4-IgG seropositivity in 73.5%. The diagnosis of NMOSD was established in 37.5% of LETM patients according to AQP4-IgG positivity and in 5% of LETM patients if the AQP4-IgG result was unknown.
Conclusions
The characteristics of this series are similar to those of other Western populations. The AQP4-IgG testing assists in the diagnosis of NMOSD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aquaporin 4 - blood</subject><subject>Autoantibodies - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>ensaio enzimático</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>epidemiologia</subject><subject>estudo transversal</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neuromielite óptica</subject><subject>Neuromyelitis Optica - diagnosis</subject><subject>NEUROSCIENCES</subject><subject>Phenotype</subject><subject>PSYCHIATRY</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>0004-282X</issn><issn>1678-4227</issn><issn>1678-4227</issn><issn>0004-282X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNUjuP1DAQjhCI2zv4ATQoJU2O8SNOTAcnOE6coAAkOmviTFivkjjYicTy6_GS3UWiorHl-R76ZsZZ9ozBNSs1vAQAWfCaf-PAFDAtHmQbpqq6kJxXD7PNGb_ILmPcAXCpdfU4u0g1rqAqN9mHj7QEP-ypd7OLuZ9mZ_FVPm1p9PN-cja3WwxoZwouJizmbswxfxPwl-sdjrnFSHlMKMUn2aMO-0hPj_dV9vXd2y8374v7T7d3N6_vC1tyMRfMNm1pCUVbp5xMNJqQN8g0SIkakUCxVldSEdVdpVjNEXRnQbcNSKq1uMruVt_W485MwQ0Y9sajM38KPnw3GFLWnoxC3cjOWi5FKZUQWmHLWsGSqQTeUPK6Xr2iddR7s_NLGFN48_kwPHMcbpUeHA5HErxYBVPwPxaKsxlctNT3OJJfomF1VaW-mPovKitLqBgkKlupNvgYA3XnthiYw67NKc7P066T5vnRfmkGas-K03ITAVbCvHU00N_e_vU8_x_xG7Szrtk</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Del Negro, Maria Cristina</creator><creator>Marinho, Patricia Beatriz Christino</creator><creator>Papais-Alvarenga, Regina Maria</creator><general>Thieme Revinter Publicações Ltda</general><general>Academia Brasileira de Neurologia - ABNEURO</general><general>Academia Brasileira de Neurologia (ABNEURO)</general><scope>0U6</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>201702</creationdate><title>Neuromyelitis optica: phenotypic characteristics in a Brazilian case series</title><author>Del Negro, Maria Cristina ; Marinho, Patricia Beatriz Christino ; Papais-Alvarenga, Regina Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-1cbd5cea3d842213b9ea2ba19044a9aae061d9746ee8f76182a09fc09db04e893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aquaporin 4 - blood</topic><topic>Autoantibodies - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>ensaio enzimático</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>epidemiologia</topic><topic>estudo transversal</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neuromielite óptica</topic><topic>Neuromyelitis Optica - diagnosis</topic><topic>NEUROSCIENCES</topic><topic>Phenotype</topic><topic>PSYCHIATRY</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Del Negro, Maria Cristina</creatorcontrib><creatorcontrib>Marinho, Patricia Beatriz Christino</creatorcontrib><creatorcontrib>Papais-Alvarenga, Regina Maria</creatorcontrib><collection>Thieme Connect Journals Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Arquivos de neuro-psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Del Negro, Maria Cristina</au><au>Marinho, Patricia Beatriz Christino</au><au>Papais-Alvarenga, Regina Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuromyelitis optica: phenotypic characteristics in a Brazilian case series</atitle><jtitle>Arquivos de neuro-psiquiatria</jtitle><addtitle>Arq Neuropsiquiatr</addtitle><date>2017-02</date><risdate>2017</risdate><volume>75</volume><issue>2</issue><spage>81</spage><epage>86</epage><pages>81-86</pages><issn>0004-282X</issn><issn>1678-4227</issn><eissn>1678-4227</eissn><eissn>0004-282X</eissn><abstract>ABSTRACT
The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population.
Objective
To describe the characteristics of 34 Brazilian NMO patients. To evaluate the contribution of the 2015 criteria to the diagnosis of NMO spectrum disorders (NMOSD) in 40 patients with longitudinal extensive transverse myelitis (LEMT).
Methods
This is a retrospective, descriptive and analytic study.
Results
Among NMO patients, there was a predominance of women, with onset in the fourth decade of life, and AQP4-IgG seropositivity in 73.5%. The diagnosis of NMOSD was established in 37.5% of LETM patients according to AQP4-IgG positivity and in 5% of LETM patients if the AQP4-IgG result was unknown.
Conclusions
The characteristics of this series are similar to those of other Western populations. The AQP4-IgG testing assists in the diagnosis of NMOSD.</abstract><cop>Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil</cop><pub>Thieme Revinter Publicações Ltda</pub><pmid>28226075</pmid><doi>10.1590/0004-282X20160193</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Thieme Connect Journals Open Access |
| subjects | Adolescent Adult Aged Aquaporin 4 - blood Autoantibodies - blood Child Child, Preschool ensaio enzimático Enzyme-Linked Immunosorbent Assay epidemiologia estudo transversal Female Humans Male Middle Aged neuromielite óptica Neuromyelitis Optica - diagnosis NEUROSCIENCES Phenotype PSYCHIATRY Retrospective Studies Young Adult |
| title | Neuromyelitis optica: phenotypic characteristics in a Brazilian case series |
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