Neurobiology of apathy in Alzheimer's disease
Apathy is considered the most frequent neuropsychiatric disturbance in dementia and its outcome is generally deleterious. Apathy can be related to a dysfunction of the anatomical-system that supports the generation of voluntary actions, namely the prefrontal cortex and/or the prefrontal-subcortical...
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| Veröffentlicht in: | Arquivos de neuro-psiquiatria 2008-06, Vol.66 (2B), p.436-443 |
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| container_title | Arquivos de neuro-psiquiatria |
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| creator | Guimarães, Henrique Cerqueira Levy, Richard Teixeira, Antônio Lúcio Beato, Rogério Gomes Caramelli, Paulo |
| description | Apathy is considered the most frequent neuropsychiatric disturbance in dementia and its outcome is generally deleterious. Apathy can be related to a dysfunction of the anatomical-system that supports the generation of voluntary actions, namely the prefrontal cortex and/or the prefrontal-subcortical circuits. In Alzheimer's disease, pathological and neuroimaging data indicate that apathy is likely due to a dysfunction of the medial prefrontal cortex. Accordingly, in this review article, we propose a pathophysiological model to explain apathetic behavior in Alzheimer's disease, combining data from neuroimaging, neuropathology and experimental research on the role of orbito-frontal cortex, anterior cingulate cortex, basal ganglia and dopamine in decision-making neurobiology. |
| doi_str_mv | 10.1590/S0004-282X2008000300035 |
| format | Article |
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Apathy can be related to a dysfunction of the anatomical-system that supports the generation of voluntary actions, namely the prefrontal cortex and/or the prefrontal-subcortical circuits. In Alzheimer's disease, pathological and neuroimaging data indicate that apathy is likely due to a dysfunction of the medial prefrontal cortex. 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Apathy can be related to a dysfunction of the anatomical-system that supports the generation of voluntary actions, namely the prefrontal cortex and/or the prefrontal-subcortical circuits. In Alzheimer's disease, pathological and neuroimaging data indicate that apathy is likely due to a dysfunction of the medial prefrontal cortex. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Affective Symptoms - physiopathology Affective Symptoms - psychology Alzheimer Disease - physiopathology Alzheimer Disease - psychology Animals Basal Ganglia - physiopathology Cognition Disorders - physiopathology Cognition Disorders - psychology Decision Making - physiology Dopamine Agonists - metabolism Frontal Lobe - physiopathology Humans Models, Theoretical NEUROSCIENCES Prefrontal Cortex - physiopathology PSYCHIATRY |
| title | Neurobiology of apathy in Alzheimer's disease |
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