Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report
X-linked juvenile retinoschisis (XLRS) is a recessively inherited vitreoretinal degeneration characterized by macular pathology and splitting of the neuroretinal layers that is associated with alterations in the XLRS1 gene. There have been no therapeutic interventions known to be effective for patie...
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| Veröffentlicht in: | Arquivos brasileiros de oftalmologia 2008-03, Vol.71 (2), p.286-290 |
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| container_title | Arquivos brasileiros de oftalmologia |
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| creator | Bastos, André Luís Carvalho de Moura Freitas, Bruno de Paula Villas Boas, Oscar Ramiro, Alexandre Campelo |
| description | X-linked juvenile retinoschisis (XLRS) is a recessively inherited vitreoretinal degeneration characterized by macular pathology and splitting of the neuroretinal layers that is associated with alterations in the XLRS1 gene. There have been no therapeutic interventions known to be effective for patients with X-linked juvenile retinoschisis, but some studies are trying to determine the importance of dorzolamide for the treatment of foveal lesions in this disease. The authors, using optical coherence tomography, describe findings in a patient with X-linked juvenile retinoschisis, before and after a topical use of dorzolamide. Besides the improvement in his visual acuity, further studies are required to elucidate the real prevalence of nonresponse to dorzolamide and the frequency with which there may be a recurrence of foveal cystic changes during continued treatment. |
| doi_str_mv | 10.1590/S0004-27492008000200030 |
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There have been no therapeutic interventions known to be effective for patients with X-linked juvenile retinoschisis, but some studies are trying to determine the importance of dorzolamide for the treatment of foveal lesions in this disease. The authors, using optical coherence tomography, describe findings in a patient with X-linked juvenile retinoschisis, before and after a topical use of dorzolamide. 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Besides the improvement in his visual acuity, further studies are required to elucidate the real prevalence of nonresponse to dorzolamide and the frequency with which there may be a recurrence of foveal cystic changes during continued treatment.</description><subject>Administration, Topical</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Child</subject><subject>Humans</subject><subject>Male</subject><subject>OPHTHALMOLOGY</subject><subject>Radiography</subject><subject>Retinoschisis - diagnostic imaging</subject><subject>Retinoschisis - drug therapy</subject><subject>Sulfonamides - administration & dosage</subject><subject>Thiophenes - administration & dosage</subject><subject>Time Factors</subject><issn>0004-2749</issn><issn>1678-2925</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtOwzAQ9AFES-EXwCduKXacxDE3VPGSKnGASnCyHGejuqRxsB0QfD0ureCAxGk0uzM7q0HolJIpzQU5fyCEZEnKM5ESUkYSgTCyh8Y_ixE69H4VN5kQ-QEa0TKnRcaKMXpeeMC2wcH2RqsW19Z92latTQ24sQ73KhjogsfvJizxU9Ka7gVqvBreoDMtYAfBdNbrpfHGX2Ct_GbWWxeO0H6jWg_HO5ygxfXV4-w2md_f3M0u54lmqQgJTbOSMBCgC1HkXOuGNfE1nfKaVmVFVZVHyoSuWNUUJddcC6JIDXmmBSWKTdB0e9drA62VKzu4LgbK717kn16i4Wxr6J19HcAHuTZeQ9uqDuzgJacFzXjOo5BvhdpZ7x00sndmrdyHpERuqv8n4mQXMVRrqH99u97ZFzXTfuo</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Bastos, André Luís Carvalho de Moura</creator><creator>Freitas, Bruno de Paula</creator><creator>Villas Boas, Oscar</creator><creator>Ramiro, Alexandre Campelo</creator><general>Conselho Brasileiro de Oftalmologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20080301</creationdate><title>Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report</title><author>Bastos, André Luís Carvalho de Moura ; Freitas, Bruno de Paula ; Villas Boas, Oscar ; Ramiro, Alexandre Campelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-124803e9ec69657ccf3f643c27d1b8b1ab564339cb3bf687c7c90a0de54c910a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Topical</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>Child</topic><topic>Humans</topic><topic>Male</topic><topic>OPHTHALMOLOGY</topic><topic>Radiography</topic><topic>Retinoschisis - diagnostic imaging</topic><topic>Retinoschisis - drug therapy</topic><topic>Sulfonamides - administration & dosage</topic><topic>Thiophenes - administration & dosage</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bastos, André Luís Carvalho de Moura</creatorcontrib><creatorcontrib>Freitas, Bruno de Paula</creatorcontrib><creatorcontrib>Villas Boas, Oscar</creatorcontrib><creatorcontrib>Ramiro, Alexandre Campelo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Arquivos brasileiros de oftalmologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bastos, André Luís Carvalho de Moura</au><au>Freitas, Bruno de Paula</au><au>Villas Boas, Oscar</au><au>Ramiro, Alexandre Campelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report</atitle><jtitle>Arquivos brasileiros de oftalmologia</jtitle><addtitle>Arq Bras Oftalmol</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>71</volume><issue>2</issue><spage>286</spage><epage>290</epage><pages>286-290</pages><issn>0004-2749</issn><issn>1678-2925</issn><abstract>X-linked juvenile retinoschisis (XLRS) is a recessively inherited vitreoretinal degeneration characterized by macular pathology and splitting of the neuroretinal layers that is associated with alterations in the XLRS1 gene. 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| fulltext | fulltext |
| identifier | ISSN: 0004-2749 |
| ispartof | Arquivos brasileiros de oftalmologia, 2008-03, Vol.71 (2), p.286-290 |
| issn | 0004-2749 1678-2925 |
| language | eng |
| recordid | cdi_scielo_journals_S0004_27492008000200030 |
| source | MEDLINE; IngentaConnect Free/Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Topical Antihypertensive Agents - administration & dosage Child Humans Male OPHTHALMOLOGY Radiography Retinoschisis - diagnostic imaging Retinoschisis - drug therapy Sulfonamides - administration & dosage Thiophenes - administration & dosage Time Factors |
| title | Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report |
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