Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature
Craniopharyngiomas and germ cell tumors (GCT) may affect the pituitary-hypothalamic region during childhood. Although different in origin, their clinical and radiological features may be similar. In this article we present a 5-year-old girl with clinical and radiological findings (computer tomograph...
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| Veröffentlicht in: | Arquivos brasileiros de endocrinologia e metabologia 2008-12, Vol.52 (9), p.1501-1504 |
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| container_title | Arquivos brasileiros de endocrinologia e metabologia |
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| creator | Chang, Claudia Veiga Nunes, Vânia dos Santos Felicio, Andre Carvalho Zanini, Marco Antonio Cunha-Neto, Malebranche B C de Castro, Ana Valeria Barros |
| description | Craniopharyngiomas and germ cell tumors (GCT) may affect the pituitary-hypothalamic region during childhood. Although different in origin, their clinical and radiological features may be similar. In this article we present a 5-year-old girl with clinical and radiological findings (computer tomography calcification) that were initially considered as craniopharyngioma. However clinical outcome, blood and cerebral spinal fluid tumoral markers, and results from anatomopathology and immunohistochemistry disclosed a mixed GCT. This case report highlights that some clinical features and radiological findings of pituitary-hypothalamic tumors may be misdiagnosed as craniopharyngioma mainly when there is a mature teratoma with cartilaginous tissue differentiation. |
| doi_str_mv | 10.1590/S0004-27302008000900015 |
| format | Article |
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Although different in origin, their clinical and radiological features may be similar. In this article we present a 5-year-old girl with clinical and radiological findings (computer tomography calcification) that were initially considered as craniopharyngioma. However clinical outcome, blood and cerebral spinal fluid tumoral markers, and results from anatomopathology and immunohistochemistry disclosed a mixed GCT. This case report highlights that some clinical features and radiological findings of pituitary-hypothalamic tumors may be misdiagnosed as craniopharyngioma mainly when there is a mature teratoma with cartilaginous tissue differentiation.</description><identifier>ISSN: 0004-2730</identifier><identifier>ISSN: 1677-9487</identifier><identifier>EISSN: 1677-9487</identifier><identifier>EISSN: 0004-2730</identifier><identifier>DOI: 10.1590/S0004-27302008000900015</identifier><identifier>PMID: 19197460</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Endocrinologia e Metabologia</publisher><subject>Child, Preschool ; Craniopharyngioma - diagnostic imaging ; Craniopharyngioma - pathology ; Craniopharyngioma - surgery ; Diagnosis, Differential ; ENDOCRINOLOGY & METABOLISM ; Female ; Humans ; Hypothalamic Neoplasms - diagnostic imaging ; Hypothalamic Neoplasms - pathology ; Hypothalamic Neoplasms - surgery ; Neoplasms, Germ Cell and Embryonal - diagnostic imaging ; Neoplasms, Germ Cell and Embryonal - pathology ; Neoplasms, Germ Cell and Embryonal - surgery ; Pituitary Neoplasms - diagnostic imaging ; Pituitary Neoplasms - pathology ; Pituitary Neoplasms - surgery ; Radiography ; Teratoma - diagnostic imaging ; Teratoma - pathology ; Teratoma - surgery</subject><ispartof>Arquivos brasileiros de endocrinologia e metabologia, 2008-12, Vol.52 (9), p.1501-1504</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-bae3a3a8caa60fbd1241c4cef7a17cbfdebd2a5ccc7ff00534dadff59a0516df3</citedby><cites>FETCH-LOGICAL-c399t-bae3a3a8caa60fbd1241c4cef7a17cbfdebd2a5ccc7ff00534dadff59a0516df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19197460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Claudia Veiga</creatorcontrib><creatorcontrib>Nunes, Vânia dos Santos</creatorcontrib><creatorcontrib>Felicio, Andre Carvalho</creatorcontrib><creatorcontrib>Zanini, Marco Antonio</creatorcontrib><creatorcontrib>Cunha-Neto, Malebranche B C</creatorcontrib><creatorcontrib>de Castro, Ana Valeria Barros</creatorcontrib><title>Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature</title><title>Arquivos brasileiros de endocrinologia e metabologia</title><addtitle>Arq Bras Endocrinol Metabol</addtitle><description>Craniopharyngiomas and germ cell tumors (GCT) may affect the pituitary-hypothalamic region during childhood. Although different in origin, their clinical and radiological features may be similar. In this article we present a 5-year-old girl with clinical and radiological findings (computer tomography calcification) that were initially considered as craniopharyngioma. However clinical outcome, blood and cerebral spinal fluid tumoral markers, and results from anatomopathology and immunohistochemistry disclosed a mixed GCT. This case report highlights that some clinical features and radiological findings of pituitary-hypothalamic tumors may be misdiagnosed as craniopharyngioma mainly when there is a mature teratoma with cartilaginous tissue differentiation.</description><subject>Child, Preschool</subject><subject>Craniopharyngioma - diagnostic imaging</subject><subject>Craniopharyngioma - pathology</subject><subject>Craniopharyngioma - surgery</subject><subject>Diagnosis, Differential</subject><subject>ENDOCRINOLOGY & METABOLISM</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothalamic Neoplasms - diagnostic imaging</subject><subject>Hypothalamic Neoplasms - pathology</subject><subject>Hypothalamic Neoplasms - surgery</subject><subject>Neoplasms, Germ Cell and Embryonal - diagnostic imaging</subject><subject>Neoplasms, Germ Cell and Embryonal - pathology</subject><subject>Neoplasms, Germ Cell and Embryonal - surgery</subject><subject>Pituitary Neoplasms - diagnostic imaging</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Radiography</subject><subject>Teratoma - diagnostic imaging</subject><subject>Teratoma - pathology</subject><subject>Teratoma - surgery</subject><issn>0004-2730</issn><issn>1677-9487</issn><issn>1677-9487</issn><issn>0004-2730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kclOxDAMhiMEgmF5BcgLFJIukwk3hNgkEAfgXLmJM5NR21RJynLnwQnMAAckDpFj-f9s-TchR5wd80qykwfGWJnlomA5Y7OUyPR4tUEmfCpEJsuZ2CSTH9EO2Q1hyVheSplvkx0uuRTllE3I-519RU3n6DuqsG1pHDvnqTM0LpAONo42gn_LFm-DiwtoobOKepxb19PBY8A-2n5OIVDlobduWCR1n8odnFIFAZN4cD5S6HX6Plt8-W7e2oge4uhxn2wZaAMerOMeebq8eDy_zm7vr27Oz24zVUgZswawgAJmCmDKTKN5XnJVKjQCuFCN0djoHCqllDCGsaooNWhjKgms4lNtij1yvOoblMXW1Us3-j4NrL_srP_YmQCxApR3IXg09eBtlzasOas_D_EPebgih7HpUP9ya-eLD3P6hlI</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Chang, Claudia Veiga</creator><creator>Nunes, Vânia dos Santos</creator><creator>Felicio, Andre Carvalho</creator><creator>Zanini, Marco Antonio</creator><creator>Cunha-Neto, Malebranche B C</creator><creator>de Castro, Ana Valeria Barros</creator><general>Sociedade Brasileira de Endocrinologia e Metabologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope></search><sort><creationdate>200812</creationdate><title>Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature</title><author>Chang, Claudia Veiga ; Nunes, Vânia dos Santos ; Felicio, Andre Carvalho ; Zanini, Marco Antonio ; Cunha-Neto, Malebranche B C ; de Castro, Ana Valeria Barros</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-bae3a3a8caa60fbd1241c4cef7a17cbfdebd2a5ccc7ff00534dadff59a0516df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Child, Preschool</topic><topic>Craniopharyngioma - diagnostic imaging</topic><topic>Craniopharyngioma - pathology</topic><topic>Craniopharyngioma - surgery</topic><topic>Diagnosis, Differential</topic><topic>ENDOCRINOLOGY & METABOLISM</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothalamic Neoplasms - diagnostic imaging</topic><topic>Hypothalamic Neoplasms - pathology</topic><topic>Hypothalamic Neoplasms - surgery</topic><topic>Neoplasms, Germ Cell and Embryonal - diagnostic imaging</topic><topic>Neoplasms, Germ Cell and Embryonal - pathology</topic><topic>Neoplasms, Germ Cell and Embryonal - surgery</topic><topic>Pituitary Neoplasms - diagnostic imaging</topic><topic>Pituitary Neoplasms - pathology</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Radiography</topic><topic>Teratoma - diagnostic imaging</topic><topic>Teratoma - pathology</topic><topic>Teratoma - surgery</topic><toplevel>online_resources</toplevel><creatorcontrib>Chang, Claudia Veiga</creatorcontrib><creatorcontrib>Nunes, Vânia dos Santos</creatorcontrib><creatorcontrib>Felicio, Andre Carvalho</creatorcontrib><creatorcontrib>Zanini, Marco Antonio</creatorcontrib><creatorcontrib>Cunha-Neto, Malebranche B C</creatorcontrib><creatorcontrib>de Castro, Ana Valeria Barros</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SciELO</collection><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Claudia Veiga</au><au>Nunes, Vânia dos Santos</au><au>Felicio, Andre Carvalho</au><au>Zanini, Marco Antonio</au><au>Cunha-Neto, Malebranche B C</au><au>de Castro, Ana Valeria Barros</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature</atitle><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle><addtitle>Arq Bras Endocrinol Metabol</addtitle><date>2008-12</date><risdate>2008</risdate><volume>52</volume><issue>9</issue><spage>1501</spage><epage>1504</epage><pages>1501-1504</pages><issn>0004-2730</issn><issn>1677-9487</issn><eissn>1677-9487</eissn><eissn>0004-2730</eissn><abstract>Craniopharyngiomas and germ cell tumors (GCT) may affect the pituitary-hypothalamic region during childhood. Although different in origin, their clinical and radiological features may be similar. In this article we present a 5-year-old girl with clinical and radiological findings (computer tomography calcification) that were initially considered as craniopharyngioma. However clinical outcome, blood and cerebral spinal fluid tumoral markers, and results from anatomopathology and immunohistochemistry disclosed a mixed GCT. This case report highlights that some clinical features and radiological findings of pituitary-hypothalamic tumors may be misdiagnosed as craniopharyngioma mainly when there is a mature teratoma with cartilaginous tissue differentiation.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Endocrinologia e Metabologia</pub><pmid>19197460</pmid><doi>10.1590/S0004-27302008000900015</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Child, Preschool Craniopharyngioma - diagnostic imaging Craniopharyngioma - pathology Craniopharyngioma - surgery Diagnosis, Differential ENDOCRINOLOGY & METABOLISM Female Humans Hypothalamic Neoplasms - diagnostic imaging Hypothalamic Neoplasms - pathology Hypothalamic Neoplasms - surgery Neoplasms, Germ Cell and Embryonal - diagnostic imaging Neoplasms, Germ Cell and Embryonal - pathology Neoplasms, Germ Cell and Embryonal - surgery Pituitary Neoplasms - diagnostic imaging Pituitary Neoplasms - pathology Pituitary Neoplasms - surgery Radiography Teratoma - diagnostic imaging Teratoma - pathology Teratoma - surgery |
| title | Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature |
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