Hyperthyroidism due to secretion of human chorionic gonadotropin in a patient with metastatic choriocarcinoma
A 26-year-old pregnant woman presenting with repeated episodes of vaginal bleeding, weight loss, and shortness of breath was diagnosed with choriocarcinoma with metastases to both lungs. Chorionic gonadotropin levels (hCG) were >2.5 x 10(6)mU/mL. Consistent with hCG-induced subclinical hyperthyro...
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| Veröffentlicht in: | Arquivos brasileiros de endocrinologia e metabologia 2005-04, Vol.49 (2), p.319-322 |
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| creator | Meister, Ludimyla H F Hauck, Patrícia R Graf, Hans Carvalho, Gisah A |
| description | A 26-year-old pregnant woman presenting with repeated episodes of vaginal bleeding, weight loss, and shortness of breath was diagnosed with choriocarcinoma with metastases to both lungs. Chorionic gonadotropin levels (hCG) were >2.5 x 10(6)mU/mL. Consistent with hCG-induced subclinical hyperthyroidism, she had a suppressed TSH of 0.037 mU/L (0.49 - 4.67), a T4 of 18.1 microg/dL (4.9 - 10.7), and T3 of 136 ng/dL (45 - 137). Chemotherapy with a combined regimen with etoposide, methotrexate, and dactinomycine was started. The initial course was complicated by urosepsis with respiratory distress requiring endotracheal intubation for 3 days. She then improved rapidly, and her thyroid function tests were within normal limits by day 12. Six months later, after ten cycles of chemotherapy, the patient was in remission without signs of residual tumor or hCG-induced paraneoplastic activity. |
| doi_str_mv | 10.1590/S0004-27302005000200022 |
| format | Article |
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Chorionic gonadotropin levels (hCG) were >2.5 x 10(6)mU/mL. Consistent with hCG-induced subclinical hyperthyroidism, she had a suppressed TSH of 0.037 mU/L (0.49 - 4.67), a T4 of 18.1 microg/dL (4.9 - 10.7), and T3 of 136 ng/dL (45 - 137). Chemotherapy with a combined regimen with etoposide, methotrexate, and dactinomycine was started. The initial course was complicated by urosepsis with respiratory distress requiring endotracheal intubation for 3 days. She then improved rapidly, and her thyroid function tests were within normal limits by day 12. Six months later, after ten cycles of chemotherapy, the patient was in remission without signs of residual tumor or hCG-induced paraneoplastic activity.</description><identifier>ISSN: 0004-2730</identifier><identifier>ISSN: 1677-9487</identifier><identifier>EISSN: 0004-2730</identifier><identifier>DOI: 10.1590/S0004-27302005000200022</identifier><identifier>PMID: 16184264</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Endocrinologia e Metabologia</publisher><subject>Adult ; Choriocarcinoma - secondary ; Chorionic Gonadotropin - secretion ; ENDOCRINOLOGY & METABOLISM ; Female ; Humans ; Hyperthyroidism - drug therapy ; Hyperthyroidism - etiology ; Lung Neoplasms - secondary ; Pregnancy ; Receptors, Thyrotropin - metabolism ; Thyroid Function Tests ; Uterine Neoplasms - pathology</subject><ispartof>Arquivos brasileiros de endocrinologia e metabologia, 2005-04, Vol.49 (2), p.319-322</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3142-5e719f6cc614faf79d6a7b5c00a7aea8fc4717e8fbc5103bc9ce9871181e4f5f3</citedby><cites>FETCH-LOGICAL-c3142-5e719f6cc614faf79d6a7b5c00a7aea8fc4717e8fbc5103bc9ce9871181e4f5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16184264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meister, Ludimyla H F</creatorcontrib><creatorcontrib>Hauck, Patrícia R</creatorcontrib><creatorcontrib>Graf, Hans</creatorcontrib><creatorcontrib>Carvalho, Gisah A</creatorcontrib><title>Hyperthyroidism due to secretion of human chorionic gonadotropin in a patient with metastatic choriocarcinoma</title><title>Arquivos brasileiros de endocrinologia e metabologia</title><addtitle>Arq Bras Endocrinol Metabol</addtitle><description>A 26-year-old pregnant woman presenting with repeated episodes of vaginal bleeding, weight loss, and shortness of breath was diagnosed with choriocarcinoma with metastases to both lungs. Chorionic gonadotropin levels (hCG) were >2.5 x 10(6)mU/mL. Consistent with hCG-induced subclinical hyperthyroidism, she had a suppressed TSH of 0.037 mU/L (0.49 - 4.67), a T4 of 18.1 microg/dL (4.9 - 10.7), and T3 of 136 ng/dL (45 - 137). Chemotherapy with a combined regimen with etoposide, methotrexate, and dactinomycine was started. The initial course was complicated by urosepsis with respiratory distress requiring endotracheal intubation for 3 days. She then improved rapidly, and her thyroid function tests were within normal limits by day 12. Six months later, after ten cycles of chemotherapy, the patient was in remission without signs of residual tumor or hCG-induced paraneoplastic activity.</description><subject>Adult</subject><subject>Choriocarcinoma - secondary</subject><subject>Chorionic Gonadotropin - secretion</subject><subject>ENDOCRINOLOGY & METABOLISM</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperthyroidism - drug therapy</subject><subject>Hyperthyroidism - etiology</subject><subject>Lung Neoplasms - secondary</subject><subject>Pregnancy</subject><subject>Receptors, Thyrotropin - metabolism</subject><subject>Thyroid Function Tests</subject><subject>Uterine Neoplasms - pathology</subject><issn>0004-2730</issn><issn>1677-9487</issn><issn>0004-2730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UV1LwzAUDaK4Of0LmiffNpN-pX2UoU4Y-KA-l-z2xma0TU1SZP_ezBUVBCGX3I9z7oFzCbnibMHTgt08M8aSeSRiFjGWhiLaR3REpt-D41_5hJw5tw2IpCiiUzLhGc-TKEumpF3terS-3lmjK-1aWg1IvaEOwaLXpqNG0XpoZUehNjY0NNA308nKeGt63dHwJO2l19h5-qF9TVv00vnQgZED0oLuTCvPyYmSjcOL8Z-R1_u7l-Vqvn56eFzerucQ8ySapyh4oTKAjCdKKlFUmRSbFBiTQqLMFSSCC8zVBlLO4g0UgEUuOM85JipV8YwsDnsdaGxMuTWD7YJg-eVb-ce3QLg-EHpr3gd0vmy1A2wa2aEZXJnlwbGI5QEoDkCwxjmLquytbqXdlZyV-9P8I3E5SgybFqsf3niL-BNBWYlc</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Meister, Ludimyla H F</creator><creator>Hauck, Patrícia R</creator><creator>Graf, Hans</creator><creator>Carvalho, Gisah A</creator><general>Sociedade Brasileira de Endocrinologia e Metabologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope></search><sort><creationdate>20050401</creationdate><title>Hyperthyroidism due to secretion of human chorionic gonadotropin in a patient with metastatic choriocarcinoma</title><author>Meister, Ludimyla H F ; Hauck, Patrícia R ; Graf, Hans ; Carvalho, Gisah A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3142-5e719f6cc614faf79d6a7b5c00a7aea8fc4717e8fbc5103bc9ce9871181e4f5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Choriocarcinoma - secondary</topic><topic>Chorionic Gonadotropin - secretion</topic><topic>ENDOCRINOLOGY & METABOLISM</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperthyroidism - drug therapy</topic><topic>Hyperthyroidism - etiology</topic><topic>Lung Neoplasms - secondary</topic><topic>Pregnancy</topic><topic>Receptors, Thyrotropin - metabolism</topic><topic>Thyroid Function Tests</topic><topic>Uterine Neoplasms - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Meister, Ludimyla H F</creatorcontrib><creatorcontrib>Hauck, Patrícia R</creatorcontrib><creatorcontrib>Graf, Hans</creatorcontrib><creatorcontrib>Carvalho, Gisah A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meister, Ludimyla H F</au><au>Hauck, Patrícia R</au><au>Graf, Hans</au><au>Carvalho, Gisah A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperthyroidism due to secretion of human chorionic gonadotropin in a patient with metastatic choriocarcinoma</atitle><jtitle>Arquivos brasileiros de endocrinologia e metabologia</jtitle><addtitle>Arq Bras Endocrinol Metabol</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>49</volume><issue>2</issue><spage>319</spage><epage>322</epage><pages>319-322</pages><issn>0004-2730</issn><issn>1677-9487</issn><eissn>0004-2730</eissn><abstract>A 26-year-old pregnant woman presenting with repeated episodes of vaginal bleeding, weight loss, and shortness of breath was diagnosed with choriocarcinoma with metastases to both lungs. Chorionic gonadotropin levels (hCG) were >2.5 x 10(6)mU/mL. Consistent with hCG-induced subclinical hyperthyroidism, she had a suppressed TSH of 0.037 mU/L (0.49 - 4.67), a T4 of 18.1 microg/dL (4.9 - 10.7), and T3 of 136 ng/dL (45 - 137). Chemotherapy with a combined regimen with etoposide, methotrexate, and dactinomycine was started. The initial course was complicated by urosepsis with respiratory distress requiring endotracheal intubation for 3 days. She then improved rapidly, and her thyroid function tests were within normal limits by day 12. Six months later, after ten cycles of chemotherapy, the patient was in remission without signs of residual tumor or hCG-induced paraneoplastic activity.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Endocrinologia e Metabologia</pub><pmid>16184264</pmid><doi>10.1590/S0004-27302005000200022</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Choriocarcinoma - secondary Chorionic Gonadotropin - secretion ENDOCRINOLOGY & METABOLISM Female Humans Hyperthyroidism - drug therapy Hyperthyroidism - etiology Lung Neoplasms - secondary Pregnancy Receptors, Thyrotropin - metabolism Thyroid Function Tests Uterine Neoplasms - pathology |
| title | Hyperthyroidism due to secretion of human chorionic gonadotropin in a patient with metastatic choriocarcinoma |
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