Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes
Abstract The Hancornia speciosa latex reveals angiogenic, osteogenic, and anti-inflammatory properties, which present its potential for developing of wound healing drugs; however, the latex compounds responsible for angiogenesis remain unknown. One strategy to screen these active compounds is evalua...
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| creator | D’ABADIA, PATRÍCIA L. BAILÃO, ELISA FLÁVIA LUIZ C. LINO JÚNIOR, RUY S. OLIVEIRA, MATHEUS GABRIEL SILVA, VINICIUS B. OLIVEIRA, LEANDRA A.R. CONCEIÇÃO, EDEMILSON C. MELO-REIS, PAULO ROBERTO BORGES, LEONARDO LUIZ GONÇALVES, PABLO JOSÉ ALMEIDA, LUCIANE M. |
| description | Abstract The Hancornia speciosa latex reveals angiogenic, osteogenic, and anti-inflammatory properties, which present its potential for developing of wound healing drugs; however, the latex compounds responsible for angiogenesis remain unknown. One strategy to screen these active compounds is evaluation of latex fractions. This study aimed to obtain different fractions of latex and evaluate its angiogenic activity separately using the chick chorioallantoic membrane (CAM) assay. The serum (SE) fraction was responsible for angiogenesis, which was subject to biochemical characterization and computational simulations in order to understand the contribution of H. speciosa latex in wound healing process. Our results revealed weak antioxidant potential and absence of antimicrobial activity in the SE fraction. Phytochemical analysis identified chlorogenic acids (CGA) as the main compound of SE fraction. CGA bioactivity predictions identify different molecules associated with extracellular matrix (ECM) remodeling, such as metalloproteinases, which also are overexpressed in our CAM assay experiment. Docking simulations revealed the interactions between CGA and matrix metalloproteinase 2. In conclusion, SE latex fraction stimulates angiogenesis and may influence ECM remodeling. These properties may contribute to the wound healing process, and also confirm the widespread use of this plant. |
| doi_str_mv | 10.1590/0001-3765202020190107 |
| format | Article |
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One strategy to screen these active compounds is evaluation of latex fractions. This study aimed to obtain different fractions of latex and evaluate its angiogenic activity separately using the chick chorioallantoic membrane (CAM) assay. The serum (SE) fraction was responsible for angiogenesis, which was subject to biochemical characterization and computational simulations in order to understand the contribution of H. speciosa latex in wound healing process. Our results revealed weak antioxidant potential and absence of antimicrobial activity in the SE fraction. Phytochemical analysis identified chlorogenic acids (CGA) as the main compound of SE fraction. CGA bioactivity predictions identify different molecules associated with extracellular matrix (ECM) remodeling, such as metalloproteinases, which also are overexpressed in our CAM assay experiment. Docking simulations revealed the interactions between CGA and matrix metalloproteinase 2. In conclusion, SE latex fraction stimulates angiogenesis and may influence ECM remodeling. These properties may contribute to the wound healing process, and also confirm the widespread use of this plant.</description><identifier>ISSN: 0001-3765</identifier><identifier>ISSN: 1678-2690</identifier><identifier>EISSN: 1678-2690</identifier><identifier>DOI: 10.1590/0001-3765202020190107</identifier><language>eng</language><publisher>Academia Brasileira de Ciências</publisher><subject>chlorogenic acid ; chronic wounds ; docking simulations ; mangabeira ; MULTIDISCIPLINARY SCIENCES ; secondary metabolites</subject><ispartof>Anais da Academia Brasileira de Ciências, 2020, Vol.92 (2), p.e20190107-e20190107</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-63dad34924eeaf2ba1ad6abdf2a46f55f57168cc4d9ef7b49c3071292e6a443f3</citedby><cites>FETCH-LOGICAL-c438t-63dad34924eeaf2ba1ad6abdf2a46f55f57168cc4d9ef7b49c3071292e6a443f3</cites><orcidid>0000-0001-6737-7548 ; 0000-0002-5066-7431 ; 0000-0002-0572-5102 ; 0000-0003-1764-1480 ; 0000-0003-4113-2686 ; 0000-0002-7278-038X ; 0000-0001-9660-2572 ; 0000-0003-0692-9729 ; 0000-0003-4756-4869 ; 0000-0003-2183-3944 ; 0000-0003-0246-1073</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>D’ABADIA, PATRÍCIA L.</creatorcontrib><creatorcontrib>BAILÃO, ELISA FLÁVIA LUIZ C.</creatorcontrib><creatorcontrib>LINO JÚNIOR, RUY S.</creatorcontrib><creatorcontrib>OLIVEIRA, MATHEUS GABRIEL</creatorcontrib><creatorcontrib>SILVA, VINICIUS B.</creatorcontrib><creatorcontrib>OLIVEIRA, LEANDRA A.R.</creatorcontrib><creatorcontrib>CONCEIÇÃO, EDEMILSON C.</creatorcontrib><creatorcontrib>MELO-REIS, PAULO ROBERTO</creatorcontrib><creatorcontrib>BORGES, LEONARDO LUIZ</creatorcontrib><creatorcontrib>GONÇALVES, PABLO JOSÉ</creatorcontrib><creatorcontrib>ALMEIDA, LUCIANE M.</creatorcontrib><title>Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes</title><title>Anais da Academia Brasileira de Ciências</title><addtitle>An. Acad. Bras. Ciênc</addtitle><description>Abstract The Hancornia speciosa latex reveals angiogenic, osteogenic, and anti-inflammatory properties, which present its potential for developing of wound healing drugs; however, the latex compounds responsible for angiogenesis remain unknown. One strategy to screen these active compounds is evaluation of latex fractions. This study aimed to obtain different fractions of latex and evaluate its angiogenic activity separately using the chick chorioallantoic membrane (CAM) assay. The serum (SE) fraction was responsible for angiogenesis, which was subject to biochemical characterization and computational simulations in order to understand the contribution of H. speciosa latex in wound healing process. Our results revealed weak antioxidant potential and absence of antimicrobial activity in the SE fraction. Phytochemical analysis identified chlorogenic acids (CGA) as the main compound of SE fraction. CGA bioactivity predictions identify different molecules associated with extracellular matrix (ECM) remodeling, such as metalloproteinases, which also are overexpressed in our CAM assay experiment. Docking simulations revealed the interactions between CGA and matrix metalloproteinase 2. In conclusion, SE latex fraction stimulates angiogenesis and may influence ECM remodeling. These properties may contribute to the wound healing process, and also confirm the widespread use of this plant.</description><subject>chlorogenic acid</subject><subject>chronic wounds</subject><subject>docking simulations</subject><subject>mangabeira</subject><subject>MULTIDISCIPLINARY SCIENCES</subject><subject>secondary metabolites</subject><issn>0001-3765</issn><issn>1678-2690</issn><issn>1678-2690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVUcFu3CAQRVErZZv2EyJx7MUpYMDmGEVtEylSD03OaAzDlpVtNmBL278v7jaRCgeG0XtvZt4Qcs3ZDVeGfWGM8abttBJsu9wwzroLsuO66xuhDXtHdm-YS_KhlANjQpqe7cjLPcwu5TkCLUd0MZUaYF4nGjK4JaaZjrDgiZYlTusWFrr8QgrzPqY9zlhiqR9P8bRUAo5jBWU6wZLjiWackscxznt6zMlhKVg-kvcBxoKf_r1X5Pnb16e7--bxx_eHu9vHxsm2XxrdevCtNEIiQhADcPAaBh8ESB2UCqrjundOeoOhG6RxLeu4MAI1SNmG9oo8nHV9goM95jhB_m0TRPs3kfLeQl6iG9EG7zUTyvRDLacUGq8cCOOlFtAPCFXr5qxVXMQx2UNa81ybtz83X-2r9_W0jFX7K-HzmVDHflmxLHaKZXMHZkxrsUJyJfqeq65C1RnqciolY3jrlTO77df-V-N1v-0fIriYlw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>D’ABADIA, PATRÍCIA L.</creator><creator>BAILÃO, ELISA FLÁVIA LUIZ C.</creator><creator>LINO JÚNIOR, RUY S.</creator><creator>OLIVEIRA, MATHEUS GABRIEL</creator><creator>SILVA, VINICIUS B.</creator><creator>OLIVEIRA, LEANDRA A.R.</creator><creator>CONCEIÇÃO, EDEMILSON C.</creator><creator>MELO-REIS, PAULO ROBERTO</creator><creator>BORGES, LEONARDO LUIZ</creator><creator>GONÇALVES, PABLO JOSÉ</creator><creator>ALMEIDA, LUCIANE M.</creator><general>Academia Brasileira de Ciências</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6737-7548</orcidid><orcidid>https://orcid.org/0000-0002-5066-7431</orcidid><orcidid>https://orcid.org/0000-0002-0572-5102</orcidid><orcidid>https://orcid.org/0000-0003-1764-1480</orcidid><orcidid>https://orcid.org/0000-0003-4113-2686</orcidid><orcidid>https://orcid.org/0000-0002-7278-038X</orcidid><orcidid>https://orcid.org/0000-0001-9660-2572</orcidid><orcidid>https://orcid.org/0000-0003-0692-9729</orcidid><orcidid>https://orcid.org/0000-0003-4756-4869</orcidid><orcidid>https://orcid.org/0000-0003-2183-3944</orcidid><orcidid>https://orcid.org/0000-0003-0246-1073</orcidid></search><sort><creationdate>2020</creationdate><title>Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes</title><author>D’ABADIA, PATRÍCIA L. ; BAILÃO, ELISA FLÁVIA LUIZ C. ; LINO JÚNIOR, RUY S. ; OLIVEIRA, MATHEUS GABRIEL ; SILVA, VINICIUS B. ; OLIVEIRA, LEANDRA A.R. ; CONCEIÇÃO, EDEMILSON C. ; MELO-REIS, PAULO ROBERTO ; BORGES, LEONARDO LUIZ ; GONÇALVES, PABLO JOSÉ ; ALMEIDA, LUCIANE M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-63dad34924eeaf2ba1ad6abdf2a46f55f57168cc4d9ef7b49c3071292e6a443f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>chlorogenic acid</topic><topic>chronic wounds</topic><topic>docking simulations</topic><topic>mangabeira</topic><topic>MULTIDISCIPLINARY SCIENCES</topic><topic>secondary metabolites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D’ABADIA, PATRÍCIA L.</creatorcontrib><creatorcontrib>BAILÃO, ELISA FLÁVIA LUIZ C.</creatorcontrib><creatorcontrib>LINO JÚNIOR, RUY S.</creatorcontrib><creatorcontrib>OLIVEIRA, MATHEUS GABRIEL</creatorcontrib><creatorcontrib>SILVA, VINICIUS B.</creatorcontrib><creatorcontrib>OLIVEIRA, LEANDRA A.R.</creatorcontrib><creatorcontrib>CONCEIÇÃO, EDEMILSON C.</creatorcontrib><creatorcontrib>MELO-REIS, PAULO ROBERTO</creatorcontrib><creatorcontrib>BORGES, LEONARDO LUIZ</creatorcontrib><creatorcontrib>GONÇALVES, PABLO JOSÉ</creatorcontrib><creatorcontrib>ALMEIDA, LUCIANE M.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Anais da Academia Brasileira de Ciências</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D’ABADIA, PATRÍCIA L.</au><au>BAILÃO, ELISA FLÁVIA LUIZ C.</au><au>LINO JÚNIOR, RUY S.</au><au>OLIVEIRA, MATHEUS GABRIEL</au><au>SILVA, VINICIUS B.</au><au>OLIVEIRA, LEANDRA A.R.</au><au>CONCEIÇÃO, EDEMILSON C.</au><au>MELO-REIS, PAULO ROBERTO</au><au>BORGES, LEONARDO LUIZ</au><au>GONÇALVES, PABLO JOSÉ</au><au>ALMEIDA, LUCIANE M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes</atitle><jtitle>Anais da Academia Brasileira de Ciências</jtitle><addtitle>An. Acad. Bras. Ciênc</addtitle><date>2020</date><risdate>2020</risdate><volume>92</volume><issue>2</issue><spage>e20190107</spage><epage>e20190107</epage><pages>e20190107-e20190107</pages><issn>0001-3765</issn><issn>1678-2690</issn><eissn>1678-2690</eissn><abstract>Abstract The Hancornia speciosa latex reveals angiogenic, osteogenic, and anti-inflammatory properties, which present its potential for developing of wound healing drugs; however, the latex compounds responsible for angiogenesis remain unknown. One strategy to screen these active compounds is evaluation of latex fractions. This study aimed to obtain different fractions of latex and evaluate its angiogenic activity separately using the chick chorioallantoic membrane (CAM) assay. The serum (SE) fraction was responsible for angiogenesis, which was subject to biochemical characterization and computational simulations in order to understand the contribution of H. speciosa latex in wound healing process. Our results revealed weak antioxidant potential and absence of antimicrobial activity in the SE fraction. Phytochemical analysis identified chlorogenic acids (CGA) as the main compound of SE fraction. CGA bioactivity predictions identify different molecules associated with extracellular matrix (ECM) remodeling, such as metalloproteinases, which also are overexpressed in our CAM assay experiment. Docking simulations revealed the interactions between CGA and matrix metalloproteinase 2. In conclusion, SE latex fraction stimulates angiogenesis and may influence ECM remodeling. These properties may contribute to the wound healing process, and also confirm the widespread use of this plant.</abstract><pub>Academia Brasileira de Ciências</pub><doi>10.1590/0001-3765202020190107</doi><orcidid>https://orcid.org/0000-0001-6737-7548</orcidid><orcidid>https://orcid.org/0000-0002-5066-7431</orcidid><orcidid>https://orcid.org/0000-0002-0572-5102</orcidid><orcidid>https://orcid.org/0000-0003-1764-1480</orcidid><orcidid>https://orcid.org/0000-0003-4113-2686</orcidid><orcidid>https://orcid.org/0000-0002-7278-038X</orcidid><orcidid>https://orcid.org/0000-0001-9660-2572</orcidid><orcidid>https://orcid.org/0000-0003-0692-9729</orcidid><orcidid>https://orcid.org/0000-0003-4756-4869</orcidid><orcidid>https://orcid.org/0000-0003-2183-3944</orcidid><orcidid>https://orcid.org/0000-0003-0246-1073</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; IngentaConnect Free/Open Access Journals; Free Full-Text Journals in Chemistry |
| subjects | chlorogenic acid chronic wounds docking simulations mangabeira MULTIDISCIPLINARY SCIENCES secondary metabolites |
| title | Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes |
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