Stimulatory Effect of Estrogen Pretreatment on 3β-Hydroxysteroid Dehydrogenase Activity of Rat Testicular Tissue

Stimulatory Effect of Estrogen Pretreatment on 3β-Hydroxysteroid Dehydrogenase Activity of Rat Testicular Tissue

Summary 1. Pretreatment doses of estrogens, which brought about marked curtailment in testicular androgen production as evidenced by sex accessory organ atrophy, increased the 3β-ol-dehydrogenase content of rat testicular homogenates. Estradiol- 17β was approximately 50 times more active than diethy...

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Veröffentlicht in:Proceedings of the Society for Experimental Biology and Medicine 1956-09, Vol.92 (4), p.656-660
Hauptverfasser: Beyler, A. L., Schad, Jessy S., Arnold, Aaron
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container_title Proceedings of the Society for Experimental Biology and Medicine
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creator Beyler, A. L.
Schad, Jessy S.
Arnold, Aaron
description Summary 1. Pretreatment doses of estrogens, which brought about marked curtailment in testicular androgen production as evidenced by sex accessory organ atrophy, increased the 3β-ol-dehydrogenase content of rat testicular homogenates. Estradiol- 17β was approximately 50 times more active than diethylstilbestrol dipalmitate in this respect. 2. This evidence suggests that the reaction catalyzed by the 3β-ol-dehydrogenase system is not the limiting one with respect to disrupted androgen production induced by estrogen pretreatment.
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title Stimulatory Effect of Estrogen Pretreatment on 3β-Hydroxysteroid Dehydrogenase Activity of Rat Testicular Tissue
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